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Fat and Obesity: Molecular Mechanisms and Pathogenesis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 25 June 2025 | Viewed by 1764

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue of the International Journal of Molecular Sciences, entitled “Fat and Obesity: Molecular Mechanisms and Pathogenesis”, welcomes submissions of manuscripts that either describe an original research or review of scientific literature.

Obesity, characterized by excessive accumulation of body fat, is associated with an increased risk of developing chronic diseases, such as cardiovascular disease, type 2 diabetes, and cancers. Prevention and management of obesity and overweight can include lifestyle changes (such as diet, nutrition, eating behavior, and exercise), medications, or surgery, and is important for improving health and quality of life. This Special Issue covers both basic and clinical studies on the mechanisms, pathogenesis, and management of obesity. This will include cohort, genetics and genomics, and molecular mechanism studies and drug development-related studies in vitro and in vivo (animals and human) of single compounds, peptides, chemicals, herbal extracts, and macromolecules.

Dr. Seon-Yong Jeong
Guest Editor

Manuscript Submission Information

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Keywords

  • obesity
  • weight gain
  • adipogenesis
  • lipolysis
  • energy balance
  • hormones
  • fat oxidation
  • nutrition
  • phytomedicine
  • drug development
  • cohort studies
  • genetics and genomics studies

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Published Papers (1 paper)

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Research

18 pages, 3123 KiB  
Article
Aspirin Inhibits the In Vitro Adipogenic Differentiation of Human Adipose Tissue-Derived Stem Cells in a Dose-Dependent Manner
by Sarah Funke, Paul Severin Wiggenhauser, Anna Grundmeier, Benedikt Fuchs, Konstantin Koban, Wolfram Demmer, Riccardo E. Giunta and Constanze Kuhlmann
Int. J. Mol. Sci. 2025, 26(2), 853; https://doi.org/10.3390/ijms26020853 - 20 Jan 2025
Viewed by 1463
Abstract
Aspirin (ASA) is one of the most used medications worldwide and has shown various effects on cellular processes, including stem cell differentiation. However, the effect of ASA on adipogenesis of adipose tissue-derived stem cells (ASCs) remains largely unknown. Considering the potential application of [...] Read more.
Aspirin (ASA) is one of the most used medications worldwide and has shown various effects on cellular processes, including stem cell differentiation. However, the effect of ASA on adipogenesis of adipose tissue-derived stem cells (ASCs) remains largely unknown. Considering the potential application of ASCs in regenerative medicine and cell-based therapies, this study investigates the effects of ASA on adipogenic differentiation in human ASCs. ASCs were exposed to varying concentrations of ASA (0 µM, 400 µM, and 1000 µM) and evaluated for changes in morphology, migration, and adipogenic differentiation. While ASA exposure did not affect self-renewal potential, migration ability, or cell morphology, it significantly reduced lipid vacuole formation at 1000 µM after 21 days of adipogenic differentiation (p = 0.0025). This visible inhibition correlated with decreased expression of adipogenic markers (PPARG, ADIPOQ, and FABP4) and the proliferation marker MKi67 under ASA exposure in comparison to the control (ns). Overall, the findings demonstrate that ASA inhibits adipogenic differentiation of human ASCs in a dose-dependent manner in vitro, contrasting its known role in promoting osteogenic differentiation. This research highlights ASA’s complex effects on ASCs and emphasizes the need for further investigation into its mechanisms and potential therapeutic applications in obesity and metabolic diseases. The inhibitory effects of ASA on adipogenesis should be considered in cell-based therapies using ASCs. Full article
(This article belongs to the Special Issue Fat and Obesity: Molecular Mechanisms and Pathogenesis)
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