Molecular Research Landscape of Pulmonary Arterial Hypertension
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 3825
Special Issue Editor
Interests: pulmonary hypertension; cardiac pathology; cardiovascular pathophysiology; cardiac function; heart failure
Special Issue Information
Dear Colleagues,
Pulmonary arterial hypertension (PAH) is a complex, progressive disease marked by high blood pressure in the lung arteries, often leading to heart failure if left untreated. The molecular research landscape for PAH aims to unravel the underlying mechanisms and identify potential therapeutic targets.
Recent studies underscore the pivotal roles of genetic mutations, epigenetic modifications, and abnormal signaling pathways in PAH pathogenesis. Notable genetic factors include mutations in the BMPR2 gene and others like ALK-1, ENG, CAV1, and KCNK3, which disrupt normal vascular function and drive disease progression. Epigenetic changes, such as DNA methylation and histone modifications, also significantly impact PAH by altering gene expression and promoting abnormal cellular behavior and vascular remodeling.
Classical signaling pathways, including the endothelin, nitric oxide, and prostacyclin pathways, are essential for maintaining vascular tone and integrity. Dysregulation of these pathways leads to vasoconstriction and smooth muscle cell proliferation, characteristic of PAH. Additionally, novel signaling pathways involved in vascular modulation are being explored as therapeutic targets.
Current research efforts focus on developing precision medicine strategies that integrate genetic, epigenetic, and molecular insights to create targeted therapies. This comprehensive approach holds promise for improving patient outcomes and advancing PAH treatment. This Special Issue will spotlight recent advances in molecular PAH research. We encourage investigators to submit original (basic and translational) research articles and reviews to address molecular mechanistic insights, novel diagnostic tools, and new treatments for PAH. Topics of interest include:
- Cellular and molecular mechanisms involved in the pathophysiology of PAH;
- The role of epigenetics in PAH pathogenesis;
- Potential new biomarkers and treatments based on molecular mechanisms;
- New perspectives on direct therapies for right heart failure in PAH based on molecular mechanisms
Dr. Cármen Brás-Silva
Guest Editor
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Keywords
- pulmonary arterial hypertension
- right ventricle
- right heart failure
- molecular mechanisms
- vascular disease
- translational research
- therapy
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