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Hormone Metabolism and Signaling in Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 1030

Special Issue Editor

Special Issue Information

Dear Colleagues,

Hormone metabolism and its associated signaling pathways are essential to humans in maintaining basic functions and in response to external environmental changes. Disruptions in or disorders of internal hormone metabolism can cause systemic or specialized diseases. Furthermore, xenohormones or environmental hormones (endocrine-disrupting chemicals) can block and disrupt the natural function of hormones and the functionality of the endocrine system in the human body. On the other hand, some diseases or dysfunctions can be treated with hormonal therapy. The related pathophysiology and molecular and cellular biology of hormone actions in the human body have been important issues in human health and remain to be explored.

This Special Issue plans to give an overview of the most recent advances in the underlying pathophysiology and molecular and cellular mechanisms of hormone metabolism, as well as related diseases and their medications. It solicits any original contributions and reviews that explore the nature of hormone metabolism and associated signaling pathways, along with their health impacts on humans in different countries and communities. Studies discussing the health issues mentioned above are suitable for consideration in this Special Issue. We especially welcome advances in or any cutting-edge research on hormone metabolism and its associated signaling pathways that affect healthcare.

Potential topics include, but are not limited to, the following:

  • Hormone metabolism;
  • Signalingpathways;
  • Pathophysiology;
  • Molecular and cellular biology;
  • Diseases originating from hormone disorders;
  • Hormonal therapy;
  • Xenohormones or environmental hormones (endocrine-disrupting chemicals).

Prof. Dr. Kuo-Hu Chen
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hormone metabolism
  • signaling pathways
  • pathophysiology
  • molecular and cellular biology
  • diseases originating from hormone disorders
  • hormonal therapy

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Published Papers (1 paper)

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Review

33 pages, 1219 KiB  
Review
Circadian Clock Deregulation and Metabolic Reprogramming: A System Biology Approach to Tissue-Specific Redox Signaling and Disease Development
by Rossitza Konakchieva, Mitko Mladenov, Marina Konaktchieva, Iliyana Sazdova, Hristo Gagov and Georgi Nikolaev
Int. J. Mol. Sci. 2025, 26(13), 6267; https://doi.org/10.3390/ijms26136267 - 28 Jun 2025
Viewed by 621
Abstract
Circadian rhythms govern cellular metabolism, redox balance, and endocrine signaling in numerous tissues. However, chronic disturbance of these biological rhythms, mediated by modern lifestyle factors including shift work, sleep irregularity, and prolonged light exposure, has been increasingly associated with oxidative stress, metabolic dysregulation, [...] Read more.
Circadian rhythms govern cellular metabolism, redox balance, and endocrine signaling in numerous tissues. However, chronic disturbance of these biological rhythms, mediated by modern lifestyle factors including shift work, sleep irregularity, and prolonged light exposure, has been increasingly associated with oxidative stress, metabolic dysregulation, and the pathogenesis of chronic diseases. This review discusses recent mechanistic advances that link circadian misalignment with tissue-specific metabolic reprogramming and impaired proteostasis, focusing on metabolic inflammation and associated pathologies. Emerging work reveals a close interdependence between the circadian clock and proteasome-mediated protein turnover and highlights this interplay’s importance in maintaining redox homeostasis. Furthermore, circadian modulation of the activity of the inflammasome complex is suggested to represent an important, but largely unexplored, risk factor in the pathobiology of both malignancy and metabolic syndrome. Recently, researchers have proposed them as novel endocrine regulators of systemic energy balance and inflammation, with a focus on their circadian regulation. In addition, the emerging domains of chrono-epigenetics and tissue-specific programming of the clock pathways may serve to usher in novel therapies through precision medicine. Moving ahead, circadian-based therapeutic approaches, including time-restricted feeding, chronopharmacology, and metabolic rewiring, have high potential for re-establishing physiological domain homeostasis linked to metabolic inflammation pathologies. Elucidating this reciprocal relationship between circadian biology and cellular stress pathways may one day facilitate the generation of precise interventions aiming to alleviate the health burden associated with circadian disruption. Full article
(This article belongs to the Special Issue Hormone Metabolism and Signaling in Human Health and Disease)
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