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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Angiogenesis Research: From Novel Compounds to Mechanistic Insights and Therapeutic Strategies

edited by Juliana Luporini Dreyfuss

submission deadline 31 Jan 2026 | Viewed by 23 | Submission Open

Keywords: angiogenesis; vascular endothelial growth factor (VEGF); novel compounds; endothelial cells; drug development; advanced molecular biology; omics technologies; innovation

(This special issue belongs to the Section Molecular Biology)

Inner Ear Disorders: From Molecular Mechanisms to Treatment

edited by

Srdjan Vlajkovic

submission deadline 31 Jan 2026 | Viewed by 23 | Submission Open

Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects

(This special issue belongs to the Section Molecular Immunology)

New Advances in Functional Nanomaterials, Nanomedicines and Biosensors Based on Nucleic Acids

edited by

Yuancong Xu

and Peng Cao

submission deadline 31 Jan 2026 | Viewed by 20 | Submission Open

Keywords: nucleic acids; functional nanomaterials; nanomedicine; biosensors; DNA nanotechnology; delivery systems; self-assembly; biomedical imaging; clinical applications; diagnostics

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights and Therapeutic Advances in Cerebral and Spinal Tumors

edited by

Alexandru Vladimir Ciurea

submission deadline 31 Jan 2026 | Viewed by 19 | Submission Open

Keywords: central nervous system tumors; molecular oncology; gliomas and spinal cord neoplasms; targeted therapy and precision medicine; neuro-oncology biomarkers; tumor microenvironment; immunotherapy; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Fish Nutrition, Biochemical Pathways, and Physiological Adaptations

edited by Paula Simó-Mirabet and Fernando Naya-Català

submission deadline 31 Jan 2026 | Viewed by 17 | Submission Open

Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture

(This special issue belongs to the Section Molecular Biology)

Abiotic Stress in Plants: Physiological and Molecular Responses

edited by Edyta Zdunek-Zastocka

submission deadline 31 Jan 2026 | Viewed by 12 | Submission Open

Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Nanomedicine for Cancer Diagnosis and Therapy

edited by

Suresh Thangudu

submission deadline 31 Jan 2026 | Viewed by 12 | Submission Open

Keywords: nanomaterials; multifunctional properties; anticancer nanotechnology; image guided nano platforms; in vivo evaluation; delivery approaches; immune-nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Strategies for Melanoma Immunotherapy

edited by

Andrzej Mackiewicz

and

Piotr Rutkowski

submission deadline 31 Jan 2026 | Viewed by 7 | Submission Open

Keywords: melanoma immunotherapy; immune Checkpoint Inhibitors; combination therapies; biomarkers; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Nutrition from Cereal Foods: Molecular Perspectives

edited by

Yakindra Timilsena

submission deadline 31 Jan 2026 | Submission Open

Keywords: cereal nutrition; molecular bioavailability; plant proteins; foodomics; grain processing; bioactive compounds; gut microbiome; nutraceuticals; food matrices; sustainable foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research for Ovarian Cancer Biology and Therapeutics (Second Edition)

edited by

Carmela Ricciardelli

submission deadline 10 Feb 2026 | Viewed by 6 | Submission Open

Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapeutic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models

(This special issue belongs to the Section Molecular Oncology)

Novel Mechanisms for the Prevention and Treatment of Stroke

edited by

Cesare Patrone

submission deadline 10 Feb 2026 | Viewed by 1 | Submission Open

Keywords: stroke; pathophysiology; mechanisms; comorbidities; treatments

(This special issue belongs to the Section Molecular Neurobiology)

Cardiovascular Calcification: New Insights into Degenerative Mechanisms and Therapeutic Perspectives

edited by Antonella Bonetti

submission deadline 10 Feb 2026 | Viewed by 1 | Submission Open

Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Prediction of Protein Structure and Function, 2nd Edition

edited by

Shuai Cheng Li

submission deadline 20 Feb 2026 | 5 articles | Viewed by 14896 | Submission Open

Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment

(This special issue belongs to the Section Molecular Informatics)

Immunotherapy Versus Immune Modulation of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4772 | Submission Open

Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Drug-Induced Modulation and Immunotherapy of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4158 | Submission Open

Keywords: leukemia; dendritic cells; immunotherapy; immune modulation

(This special issue belongs to the Section Molecular Immunology)

New Advances in Bioactive Compounds in Health and Disease

edited by

Luís Silva

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3440 | Submission Open

Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition

edited by

Alessandro Fanzani

and

Silvia Codenotti

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3352 | Submission Open

Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Studies in Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3121 | Submission Open

Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics

edited by

Woon Kyu Lee

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3029 | Submission Open

Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Probiotics in Health and Disease

edited by

Jasna Novak

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1820 | Submission Open

Keywords: probiotic; microbiota; quality; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

New Insights into the Antibacterial Effect of Nano- and Micro-Materials

edited by

Krasimir Vasilev

and

Vi Khanh Truong

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1668 | Submission Open

Keywords: antibacterial coatings; biomaterials; medical devices; antimicrobial resistance; nanomedicine

(This special issue belongs to the Section Materials Science)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1634 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications

edited by

Bin Li

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1370 | Submission Open

Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Insulin Resistance Research: 2nd Edition

edited by

Byungyong Ahn

submission deadline 20 Feb 2026 | 1 articles | Viewed by 927 | Submission Open

Keywords: insulin resistance; obesity; metabolic diseases; diabetes; metabolism; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Gut Microbiota and Nutrition in Human Health (2nd Edition)

edited by

Sunmin Park

submission deadline 20 Feb 2026 | Viewed by 535 | Submission Open

Keywords: microbiome; gut; brain; obesity; diabetes; inflammation; liver; nutrition; probiotic; prebiotic

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances in the Relationship Between Diabetes and Cancers

edited by

Zsuzsanna Németh

submission deadline 20 Feb 2026 | Viewed by 309 | Submission Open

Keywords: diabetes; insulin resistance; glucose intolerance; glucolipotoxicity; ER stress; oxidative stress; cancer development

(This special issue belongs to the Section Molecular Oncology)

Mitochondrial Disorders: From Molecular Mechanisms to New Therapies

edited by

Yury Ladilov

and

Muhammad Aslam

submission deadline 20 Feb 2026 | Viewed by 222 | Submission Open

Keywords: mitochondrial disorders; mitochondrial dysfunction; molecular mechanisms; targeted therapeutic approaches; mitochondrial biology regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 20 Feb 2026 | Viewed by 215 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Genetics in Rare Diseases: A Genomic Odyssey

edited by

Klaus Brusgaard

submission deadline 20 Feb 2026 | Viewed by 212 | Submission Open

Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition)

edited by

Enrica Flori

Giorgia Cardinali

and

Vittoria Maresca

submission deadline 20 Feb 2026 | Viewed by 186 | Submission Open

Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways

(This special issue belongs to the Section Molecular Oncology)

Reactive Oxygen Species (ROS) and Metal Ions in Biological Systems

edited by

Chryssoula Drouza

and

Debbie C. Crans

submission deadline 20 Feb 2026 | Viewed by 184 | Submission Open

Keywords: reactive oxygen species; reactive oxygen species metabolism; diseases and reactive oxygen species; lipid peroxidation; metal ions and reactive oxygen species; metal based drugs; oxidative stress

(This special issue belongs to the Section Biochemistry)

Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition

edited by

Brisamar Estébanez

, María José Cuevas-González and Chun-Jung Huang

submission deadline 20 Feb 2026 | Viewed by 173 | Submission Open

Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics

(This special issue belongs to the Section Molecular Biology)

The Diversity of Life: Light to Heavy Metal Coordination Compounds of Biological Relevance

edited by

Ivayla Pantcheva

submission deadline 20 Feb 2026 | Viewed by 158 | Submission Open

Keywords: coordination compounds; metal-based drugs; antimicrobial; anti-inflammatory; antiviral agents; cancer therapy; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Advances in Vitiligo: From Mechanisms to Treatment Innovations

edited by Hyun Jeong Ju

submission deadline 20 Feb 2026 | Viewed by 112 | Submission Open

Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pain: From Bench to Bedside

edited by

Christopher Robinson

and Robert J. Yong

submission deadline 20 Feb 2026 | Viewed by 28 | Submission Open

Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding Aging in Health and Disease

edited by

Laura Cianfruglia

submission deadline 25 Feb 2026 | Viewed by 50 | Submission Open

Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging

(This special issue belongs to the Section Molecular Biology)

Obesity: From Cellular Mechanism to Potential Molecular Therapies

edited by

Veronica Jimenez

submission deadline 25 Feb 2026 | Viewed by 13 | Submission Open

Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Chronic Inflammatory Sinonasal Diseases

edited by Santos Tiago Soares

submission deadline 25 Feb 2026 | Viewed by 1 | Submission Open

Keywords: chronic rhinosinusitis; nasal polyps; type 2 inflammation; sinonasal immunopathology; molecular pathways; host– microbiome interaction; precision medicine; upper airway disease; translational research

(This special issue belongs to the Section Molecular Immunology)

Molecular Pathophysiology and Treatments of Diabetes

edited by

Carlo Acierno

submission deadline 26 Feb 2026 | Viewed by 34 | Submission Open

Keywords: diabetes mellitus; molecular pathophysiology; insulin resistance; beta-cell dysfunction; chronic inflammation; epigenetics; metabolic syndrome; SGLT2 inhibitors; GLP-1 receptor agonists; gut microbiota

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Discovery Based on Natural Products

edited by Woo-kyung Kim

submission deadline 28 Feb 2026 | 5 articles | Viewed by 5983 | Submission Open

Keywords: drug discovery; bioactive compounds; pharmacological activities and mechanisms; omics technologies

(This special issue belongs to the Section Molecular Pharmacology)

Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition

edited by

Tao Sun

and

Xujin Bao

submission deadline 28 Feb 2026 | Viewed by 15 | Submission Open

Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis

(This special issue belongs to the Section Materials Science)

Current Trends and Future Directions in Antimicrobial Peptide Research

edited by

Sara Elsa Aita

submission deadline 28 Feb 2026 | Viewed by 12 | Submission Open

Keywords: antimicrobial peptides (AMPs); host defense; structure-function; antimicrobial agents; biomedical applications; antibiotic alternatives; antibiotic resistance

(This special issue belongs to the Section Molecular Biology)

Strategies for Enhancing Skeletal Muscle Recovery and Regeneration in Health and Disease Conditions

edited by

Elen Miyabara

and

Atsushi Asakura

submission deadline 28 Feb 2026 | Viewed by 8 | Submission Open

Keywords: skeletal muscle; regeneration; muscle wasting; aging; muscle diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Extracellular Vesicles in Immune Regulation

edited by Rachel Crossland

submission deadline 28 Feb 2026 | Viewed by 1 | Submission Open

Keywords: extracellular vesicle; immune regulation; immunomodulation; antigen presentation; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Perspectives on Wound Healing

edited by

Ermelindo C. Leal

and

Eugenia Carvalho

submission deadline 20 Mar 2026 | 5 articles | Viewed by 10663 | Submission Open

Keywords: chronic wound healing; scarring; biomarkers; inflammation; angiogenesis; infection; extracellular matrix; biomaterials; tissue regeneration; therapeutic targets; innovative therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2497 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1471 | Submission Open

Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria: Central Players in Cancer

edited by

Annamaria Piscazzi

and

Domenica Mangieri

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1348 | Submission Open

Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Hormones: Evolutionary and Functional Role

edited by

Giulia Guerriero

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1118 | Submission Open

Keywords: hormone action; brain organization; sexual behavior; endocrine tissue; receptor neuroexpression; endocrine control; endocrine disruption; climate change and reproduction; hormones and evolution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Autophagy and Programmed Cell Death in Plants and Algae

edited by

Sławomir Borek

submission deadline 20 Mar 2026 | Viewed by 423 | Submission Open

Keywords: algal autophagy and PCD; autophagy-related (Atg) genes and proteins; biotic and abiotic stresses; caspase-like proteases; crop plant improvement; macro-; micro-; and mega-autophagy; metacaspases; selective autophagy; signaling; vacuolar processing enzymes (VPEs)

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 3301-3350 on page 67 of 68.

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