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Hormones: Evolutionary and Functional Role

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 837

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Guest Editor
Interdepartmental Research Center for Environment, IECEnv (CIRAm), University of Naples Federico II, 80134 Naples, Italy
Interests: climate change and reprotoxicity; antioxidative physiological defense; steroids and steroid receptors; antioxidants under steroid control; reproductive health assessment; endangered species and validation of non-destructive examination methods; biodiversity conservation microassay
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Special Issue Information

Dear Colleagues,

Recent research on hormones focuses on the control of biosynthesis in endocrine tissue, on the receptor genes expression by which they act within their target tissues, and on their evolutionary and functional relationships. Mechanisms of hormone action embrace not only the fundamental aspects of molecular biology, including the role of receptors, protein, and RNA synthesis, and events at the chromosomal level, but also the control of sexual development, brain organization, sexual behavior, endocrine disruption, and the protective effects on non-reproductive systems, such as the immune, cardiovascular, and central nervous systems, bone structure, and metabolism. Notable recent achievements regard brain endocrinology and the application of recently acquired knowledge on the mode of hormone action, with significant inroads into the problems of metabolism, cancer, and autoimmune disease in endocrine tissue, as well as in several other tissues not traditionally considered to be ‘targets’. Understanding the role and cross-talk of hormones is the fundamental answer to basic questions of reproduction, one-health conservation, and sustainability. We invite the submission of original research articles and reviews focused on the evolutionary and functional role of hormones and/or on molecules related to them.

Dr. Giulia Guerriero
Guest Editor

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Keywords

  • hormone action
  • brain organization
  • sexual behavior
  • endocrine tissue
  • receptor neuroexpression
  • endocrine control
  • endocrine disruption
  • climate change and reproduction
  • hormones and evolution

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Published Papers (1 paper)

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Research

13 pages, 1230 KiB  
Article
Gender-Dependent Effect of Progesterone on the Expression of Metallothionein Genes in Rat Inguinal Adipose Tissue
by Sylwia Szrok-Jurga, Jacek Turyn, Julian Swierczynski, Wiktoria Stelmanska, Malgorzata Presler and Ewa Stelmanska
Int. J. Mol. Sci. 2025, 26(9), 4066; https://doi.org/10.3390/ijms26094066 - 25 Apr 2025
Viewed by 136
Abstract
Metallothioneins (MTs) are low-molecular-weight metal-binding proteins potentially involved in the detoxification of heavy metals, protection against oxidative stress, and other biological processes. This study examined progesterone’s influence on Mt gene expression in rat adipose tissue. Wistar rats (females and males) received 100 mg [...] Read more.
Metallothioneins (MTs) are low-molecular-weight metal-binding proteins potentially involved in the detoxification of heavy metals, protection against oxidative stress, and other biological processes. This study examined progesterone’s influence on Mt gene expression in rat adipose tissue. Wistar rats (females and males) received 100 mg of progesterone per rat. MT mRNA and protein levels were quantified by real-time PCR and Western blotting methods. Using radioimmunoassay, the serum progesterone level was measured. In this study, progesterone administration to female rats led to a 2.5-fold increase in serum progesterone concentration and significant increases in MT-1, MT-2A mRNA, and protein levels in inguinal WAT (WATi), compared to untreated female rats. RU 486 (progesterone receptor antagonist) abolished progesterone’s influence on Mt-1 and Mt-2A gene expression in female WATi. Progesterone administration did not alter the level of Mt-3 gene expression in WATi or Mt-1 and Mt-2A in retroperitoneal WAT or brown adipose tissue in female rats. Full article
(This article belongs to the Special Issue Hormones: Evolutionary and Functional Role)
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