Novel Mechanisms for the Prevention and Treatment of Stroke
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 10 February 2026 | Viewed by 699
Special Issue Editor
Interests: stroke; diabetes; obesity; neuroplasticity; neurogenesis; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent decades, the incidence of ischemic stroke has decreased thanks to improved control of important risk factors. Furthermore, the handling of acute stroke involving the chemical and/or surgical removal of thrombotic clots has demonstrated considerable improvement. However, two in three patients with ischemic stroke die or are functionally dependent at 5 years post-stroke, and this remains one of the leading causes of death and serious disability across the world. Moreover, such numbers are expected to rise over the next few decades, primarily due to population growth/aging and comorbidities. This underlines the importance of research in this field aiming to identify new molecular and cellular targets leading to stroke, as well as those triggered after stroke and characterizing stroke pathophysiology. Once these mechanisms have been identified, new proof-of-concept studies are needed to test their therapeutic potential.
In this Special Issue of the International Journal of Molecular Sciences, authors are invited to submit a wide range of both basic research and clinical papers showing novel data about the identification of molecular and cellular mechanisms whose targeting may be important to both preventing and treating stroke; this with the aim of contributing to the international stroke research community. These papers can also focus on the effects of stroke comorbidities on newly identified cellular and molecular mechanisms, with particular focus on diabetes, dyslipidemia, depression, hypertension, obesity and heart disease, and vascular complications.
Dr. Cesare Patrone
Guest Editor
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Keywords
- stroke
- pathophysiology
- mechanisms
- comorbidities
- treatments
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