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Advances in Insulin Resistance Research: 2nd Edition

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Guest Editor
Department of Food Science and Nutrition, University of Ulsan, Ulsan 44610, Republic of Korea
Interests: metabolic diseases; insulin resistance; obesity; diabetes; glucose metabolism; lipid metabolism; aging; sarcopenia; cardiac, muscle and liver energy metabolism; mitochondria
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Special Issue Information

Dear Colleagues,

Insulin resistance arises when cells in fat, skeletal muscle, the heart and the liver cannot respond to the hormone insulin. It has been reported that insulin resistance is a critical risk factor for the development of type 2 diabetes mellitus, cardiovascular disease and other related metabolic diseases. The development of insulin resistance is strongly associated with several important metabolic pathways such as glucose/lipid metabolism, ectopic lipid accumulation, mitochondria dysfunction, ER stress and inflammation. The aim of this Special Issues is to find and delineate new molecular targets and mechanisms which reduce the main cause of insulin resistance.

Dr. Byungyong Ahn
Guest Editor

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Keywords

  • insulin resistance
  • obesity
  • metabolic diseases
  • diabetes
  • metabolism
  • inflammation

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Published Papers (1 paper)

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Review

40 pages, 548 KiB  
Review
Severe Insulin Resistance Syndromes: Clinical Spectrum and Management
by Monika Pliszka and Leszek Szablewski
Int. J. Mol. Sci. 2025, 26(12), 5669; https://doi.org/10.3390/ijms26125669 - 13 Jun 2025
Viewed by 417
Abstract
Insulin resistance is a condition wherein cells fail to adequately respond to insulin. It is a prevalent medical condition associated with several diseases, such as type 2 diabetes mellitus, metabolic syndrome, hypertension, obesity, and polycystic ovary syndrome. Insulin resistance may be involved in [...] Read more.
Insulin resistance is a condition wherein cells fail to adequately respond to insulin. It is a prevalent medical condition associated with several diseases, such as type 2 diabetes mellitus, metabolic syndrome, hypertension, obesity, and polycystic ovary syndrome. Insulin resistance may be involved in metabolic disturbances, such as hyperglycemia, hyperinsulinemia, dyslipidemia, hyperuricemia, endothelial dysfunction, elevated inflammatory markers, and a prothrombotic state. Severe insulin resistance syndromes are a heterogeneous group of rare disorders. These disorders are characterized by profound insulin resistance, substantial metabolic abnormalities, and different clinical manifestations and complications. They may be hereditary or acquired, caused by defects in insulin action and cellular responsiveness to insulin. Severe insulin resistance syndromes may also be due to aberrations in adipose tissue function and development. The majority of these disorders are associated with an increased risk of severe complications and mortality. This review aims to summarize the current knowledge on the epidemiology, pathophysiology, complications and prognosis of severe insulin resistance syndromes, as well as to categorize these syndromes by disease process, including defects in insulin receptor, intracellular insulin signaling defects, lipodystrophies, etc. Full article
(This article belongs to the Special Issue Advances in Insulin Resistance Research: 2nd Edition)
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