Advances in Angiogenesis Research: From Novel Compounds to Mechanistic Insights and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 3
Special Issue Editor
Special Issue Information
Dear Colleagues,
Angiogenesis—the formation of new blood vessels from pre-existing vasculature—is a tightly regulated physiological process essential for tissue development, repair, and regeneration. Dysregulated angiogenesis, such as pathological neovascularization, underlies the progression of various diseases, including cancer, ocular disorders, and chronic inflammation. In these cases, therapeutic strategies aimed at inhibiting angiogenesis have shown clinical relevance by targeting the abnormal vascular network that sustains disease progression. Conversely, insufficient angiogenesis can compromise tissue perfusion and regeneration, particularly in ischemic or hypoxic conditions such as chronic wounds, myocardial infarction, and neurodegenerative diseases. In these contexts, pro-angiogenic strategies and molecular inducers of neovascularization represent promising therapeutic approaches to restore tissue function and viability.
This Special Issue aims to bring together cutting-edge molecular research that advances our understanding of angiogenic mechanisms, therapeutic targets, and the development of novel compounds. We particularly encourage studies that explore innovative strategies and emerging technologies for angiogenesis modulation. Submissions addressing the effects of new synthetic or natural molecules—supported by robust molecular data from in vitro, in vivo, pre-clinical, and clinical models—are highly welcome.
We invite original research articles focused on the molecular mechanisms of angiogenesis, including signaling pathways, transcriptional and epigenetic regulation, microRNAs, extracellular vesicles, and the tumor microenvironment. Special emphasis will be placed on studies employing advanced molecular biology techniques, multi-omics approaches (genomics, transcriptomics, proteomics, metabolomics), glycobiology, and computational bioinformatics for molecular modeling. Contributions that integrate molecular biology, pharmacology, drug discovery, and biotechnological innovation to develop targeted and effective angiogenesis-based therapies are strongly encouraged.
Dr. Juliana Luporini Dreyfuss
Guest Editor
Manuscript Submission Information
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Keywords
- angiogenesis
- vascular endothelial growth factor (VEGF)
- novel compounds
- endothelial cells
- drug development
- advanced molecular biology
- omics technologies
- innovation
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