Tuberculosis: Host Immunity, Diagnosis and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 95
Special Issue Editor
2. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Intendente Güiraldes 2160, Pabellón II, 4°piso, Ciudad Universitaria, Buenos Aires C1428EGA, Argentina
Interests: tuberculosis; mycobacterium tuberculosis; autophagy; cytokines; molecular diagnosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mycobacterium tuberculosis (Mtb) has killed nearly 1000 million people since the 19th century. Currently, tuberculosis (TB) remains a major global health problem, ranking among the top ten causes of death worldwide. To achieve adequate disease control, confident diagnostics and treatment of latent infections are required. The human immune response against Mtb is highly complex, involving the participation of several different cell types and numerous immune mediators, with particular temporal dynamics on the host microenvironment. Despite the great strides made in the characterization of the acquired cellular response in TB patients, it remains to be elucidated what exactly constitutes a protective response or leads to disease pathology. Furthermore, how Mtb is able to evade host immune surveillance and persist is not yet fully elucidated. And although an affordable and effective treatment is available to fight this pathogen, TB, together with COVID-19 in 2020–2021, is the leading cause of death from a single infectious agent. Therefore, improvements in treatment are included among the central aims of developing new strategies against this disease. Accordingly, supplementing anti-TB therapy with host response modulators could augment standard TB treatment. In addition, host-directed therapies (HDT) might provide an unexploited approach as complementary anti-TB therapies, either by increasing the ability of the host immune system to eliminate mycobacteria or by limiting collateral tissue damage associated with infection. This research topic, therefore, welcomes the submission of research articles and reviews focused on the host immunity, diagnosis, and treatment of tuberculosis infection.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- The immune response of the host against Mycobacterium tuberculosis, including cellular and immunological mechanisms involved in the host response against Mtb infection, cellular and molecular pathways that control the pathogenesis of Mtb infection, and the evasion of host immune responses.
- Novel methods to prevent and diagnose Mtb.
- New approaches to improve the treatment of tuberculosis infection, including host-directed therapies (HDT).
Dr. Veronica Edith Garcia
Guest Editor
Manuscript Submission Information
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Keywords
- tuberculosis
- immune response
- diagnosis
- treatment
- antibiotics
- resistance
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