Endothelial Cells in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 814
Special Issue Editors
Interests: molecular and cellular biology; tissue regeneration; tissue repair; angiogenesis; biomaterials
2. Ud’A Techlab, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Interests: cell biology; microscophy; anatomy and morphology; biochemistry and molecular biology; oxidative stress
Special Issue Information
Dear Colleagues,
Endothelial cells are key regulators of vascular and tissue homeostasis. Their unique organization ensures both selective permeability—controlling blood flow, immune responses, and fluid exchange—and the formation of a protective barrier against toxins and pathogens. Under healthy conditions, this balance supports tissue perfusion and organ integrity. However, endothelial dysfunction is a critical early event in many diseases, including cardiovascular disorders, cancer, and inflammatory conditions. One of the major challenges for endothelial cells is managing oxidative stress, which induces significant molecular and morphological alterations. This Special Issue aims to collect manuscripts concerning investigations into the multifaceted roles of endothelial cells, highlighting recent advances in molecular and morphological events occurring in healthy endothelium and how endothelial cells can recover when damage occurs. The Special Issue seeks to provide a comprehensive view of endothelial cell biology under physiological conditions as well as their involvement in disease onset and progression.
Dr. Alessia Ricci
Prof. Dr. Amelia Cataldi
Guest Editors
Manuscript Submission Information
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Keywords
- endothelial cells
- vascular homeostasis
- tissue homeostasis
- endothelial cell biology
- endothelial cells dysfunction
- oxidative stress
- redox signaling
- aging
- endothelial regulation of tissue repair
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