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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant-Origin Bioactive Substances

edited by

Simon Bernard Iloki Assanga

submission deadline 31 Oct 2026 | 1 articles | Viewed by 603 | Submission Open

Keywords: plant-derived bioactive compounds; phytochemicals; oxidative stress; antioxidant activity; nutraceuticals; polyphenols; flavonoids; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Research on Mesenchymal Stem Cells (2nd Edition)

edited by Marcel Costuleanu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 596 | Submission Open

Keywords: mesenchymal stem cell; MSC; niche; tissue homeostasis; exosomes; microvesicles; cancer; mitochondrial exchange; MSC secretome

(This special issue belongs to the Section Molecular Biology)

Deciphering the Molecular Symphony of Microbiome-Driven Immune Modulation

edited by Edda Russo and

Sara Salvetti

submission deadline 31 Oct 2026 | Viewed by 561 | Submission Open

Keywords: microbiome; immune; microbial-host interactions

(This special issue belongs to the Section Molecular Immunology)

Molecular Research on Ischemia-Reperfusion Injury

edited by

Mustafa Arslan

and

Ayşegül Küçük

submission deadline 31 Oct 2026 | Viewed by 531 | Submission Open

Keywords: ischemia reperfusion models; experimental models; pre-post conditioning; cell death pathways; inflammation; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Underlying Natural Products for Metabolic Disease Treatment

edited by

Saioa Gómez-Zorita

submission deadline 31 Oct 2026 | Viewed by 530 | Submission Open

Keywords: metabolic diseases; natural products; MAFLD

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biopolymers and Their Application

edited by

Diego Acevedo

and

Edith Inés Yslas

submission deadline 31 Oct 2026 | 1 articles | Viewed by 484 | Submission Open

Keywords: biopolymers; biodegradable polymers; bio-based materials; biopolymer composites; sustainable materials; green chemistry; functional biopolymers; advanced polymer applications

(This special issue belongs to the Section Materials Science)

Molecular Targets for HPV-Related Head and Neck Cancer

edited by

Joshua D. Smith

submission deadline 31 Oct 2026 | Viewed by 474 | Submission Open

Keywords: human papillomavirus; HPV; head and neck; squamous cell carcinoma; recurrent; p16; immune; targeted; vaccine; antibody

(This special issue belongs to the Section Molecular Oncology)

Omics Approaches to Decipher Inborn Errors of Immunity and Secondary Immunodeficiencies

edited by

Francesco Saettini

submission deadline 31 Oct 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: inborn errors of immunity; primary immunodeficiency; secondary immunodeficiency; omics; genomics; proteomics; metabolomics; transcriptomics; lipidomics; single-cell; spatial transcriptomics; immune dysregulation

(This special issue belongs to the Section Molecular Immunology)

Design, Synthesis, and Applications of Advanced Functional Materials

edited by

Angelika Kmita

submission deadline 31 Oct 2026 | Viewed by 468 | Submission Open

Keywords: advanced functional materials; materials synthesis; nanomaterials; hybrid materials

(This special issue belongs to the Section Materials Science)

Cariovascular Diseases: From Molecular Mechanisms to Therapeutics

edited by

Paul Quax

submission deadline 31 Oct 2026 | Viewed by 466 | Submission Open

Keywords: yocardial infarction and cardiac regeneration; microvasculature in cardiovascular health and disease; gender specific aspects of cardiovascular disease; heart failure; aneurysm formation and dissection; vascular remodeling (restenosis; atherosclerosis; angioegenesis); valve failure; replacement or regeneration; atherosclerosis; imaging; new therapeutic options including non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cytomegalovirus: An Unresolved Puzzle in Transplantation

edited by

Eleonora Forte

, Zheng Zhang and Lorenzo Gallon

submission deadline 31 Oct 2026 | Viewed by 447 | Submission Open

Keywords: cytomegalovirus; latency; reactivation; transplantation; virus-host interaction; immune evasion; host immune response; omics approaches; high-throughput technologies

(This special issue belongs to the Section Molecular Microbiology)

The Latest Molecular and Psycho-Physiological Insights on “Brain Fatigue”

edited by

Takehiko Fujino

and

Masanori Honsho

submission deadline 31 Oct 2026 | Viewed by 439 | Submission Open

Keywords: epigenetics; neurotransmitter including dopamine; mitochondria dysfunction; neuroinflammation; lipidomics including plasmalogen; proteomics including neuropeptide; neural network; cognition abilities; decline in attention; judgement capacity; depressive state

(This special issue belongs to the Section Molecular Neurobiology)

Structure-Based Design of Drugs and Other Bioactive Molecules

edited by

Antonio Carrieri

submission deadline 31 Oct 2026 | Viewed by 411 | Submission Open

Keywords: three-dimensional structure; molecular descriptor; molecular similarity; database searching; drug repositioning; target fishing; novel algorithm; data prediction

(This special issue belongs to the Section Molecular Informatics)

Microenviromental Signalling in Tumorigenesis and Anti-Cancer Drugs Resistance

edited by

Pierluigi Scalia

submission deadline 31 Oct 2026 | Viewed by 406 | Submission Open

Keywords: tumor microenvironment; cancer cell signaling; paracrine and autocrine mechanisms; cancer drug resistance; oncogenic pathways; immune checkpoints; cancer immune evasion; cancer-associated fibroblasts; tumor-infiltrating lymphocytes; onco-immunology; CAR-T

(This special issue belongs to the Section Molecular Oncology)

Mechanistic Studies of Neuroplasticity

edited by Jorge Bergado

submission deadline 31 Oct 2026 | 1 articles | Viewed by 396 | Submission Open

Keywords: neural plasticity; influence of trophic factors on plasticity; molecular cascades of plasticity; restorative neurology

(This special issue belongs to the Section Molecular Neurobiology)

Extraction and Application of Natural Compound

edited by

Sakaewan Ounjaijean

submission deadline 31 Oct 2026 | Viewed by 392 | Submission Open

Keywords: natural compounds; extraction; characterization

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Intercellular Adhesion and Inflammatory Response in Cancer

edited by Anna Pryczynicz

submission deadline 31 Oct 2026 | Viewed by 381 | Submission Open

Keywords: adhesion; cancer; cancer therapy; inflammation; microenvironment

(This special issue belongs to the Section Molecular Biology)

Molecular Targeted Therapy and Epigenetic Advances in Cancer

edited by Qing Sheng Mi and

Li Zhou

submission deadline 31 Oct 2026 | Viewed by 372 | Submission Open

Keywords: cancer; epigenetic; therapeutic targets; chromatin; DNA methylation; histone modification; noncoding RNA; histone variants

(This special issue belongs to the Section Molecular Oncology)

Molecular Dynamics Simulations in Enzyme Structure–Function Relationships and Substrate Specificity

edited by

Weiwei Han

submission deadline 31 Oct 2026 | 1 articles | Viewed by 367 | Submission Open

Keywords: molecular dynamics; enzyme mechanism; structure– function relationship; substrate specificity; enzyme engineering; free energy calculation; computational enzymology; protein dynamics; molecular modeling

(This special issue belongs to the Section Molecular Informatics)

Aptamers: Insights into Functional and Structural Research

edited by

Serap Evran

submission deadline 31 Oct 2026 | Viewed by 348 | Submission Open

Keywords: nucleic acid aptamers; aptamer selection; SELEX; post-SELEX; aptamer engineering; aptasensors; diagnostic aptamers; therapeutic aptamers; aptamer– target interaction; aptamer structure

(This special issue belongs to the Section Molecular Biology)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 31 Oct 2026 | Viewed by 348 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

Molecular-Scale Design, Synthesis, and Applications of (Photo)Electrochemical Materials for Sustainable Energy and Environmental Solutions

edited by

Shiwei Lin

and

Zhaohui Xiao

submission deadline 31 Oct 2026 | Viewed by 332 | Submission Open

Keywords: molecular-scale material engineering; photoelectrocatalysis/electrocatalysis; sustainable energy conversion; atomic-precision synthesis; environmental remediation technologies

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Progress in Photobiomodulation Therapy

edited by

Amílcar Sabino Damazo

submission deadline 31 Oct 2026 | Viewed by 325 | Submission Open

Keywords: photobiomodulation (PBM); low-level light therapy (LLLT); light-emitting diodes (LEDs); mitochondrial photostimulation; anti-inflammatory effects; tissue regeneration; neuromodulation; biostimulation; clinical applications; pain management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant-Pathogen Interactions: The Role of Effectors and Host Targets

edited by

Muhammad Asif

submission deadline 31 Oct 2026 | Viewed by 323 | Submission Open

Keywords: plant immunity; effector proteins; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); NLR receptors; plant-microbe interactions; susceptibility; secreted virulence factors; signal transduction; host manipulation

(This special issue belongs to the Section Molecular Plant Sciences)

Unraveling Neurodevelopmental Disorders: A Molecular Perspective

edited by Marija-Magdalena Petrinovic

submission deadline 31 Oct 2026 | Viewed by 319 | Submission Open

Keywords: neurodevelopmental disorders; molecular neuroscience; genetics; epigenetics; functional MRI (fMRI); magnetic resonance spectroscopy (MRS); PET imaging; imaging biomarkers; translational neuroscience; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

From Molecular Mechanisms to Precision Medicine in Gastrointestinal Cancers: (Epi)genetics, Pharmacogenomics, and Emerging Biomarkers

edited by

Kostas A. Triantaphyllopoulos

submission deadline 31 Oct 2026 | Viewed by 317 | Submission Open

Keywords: gastrointestinal and colorectal cancer; genetic and epigenetic regulation; multi-omics and computational biology; molecular pathology and biomarker discovery; translational and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Lipid Metabolites in Age-Related Comorbidities: From Mechanisms to Therapeutics

edited by

Sadanand Fulzele

submission deadline 31 Oct 2026 | Viewed by 313 | Submission Open

Keywords: lipid metabolites; aging; sarcopenia; osteoporosis; osteoarthritis

(This special issue belongs to the Section Biochemistry)

Biological Materials: Molecular Mechanisms, Tissue Responses, and Translational Perspectives

edited by

Andre Luiz Sena Guimaraes

submission deadline 31 Oct 2026 | Viewed by 311 | Submission Open

Keywords: biological materials; biomaterials; molecular mechanisms; regenerative medicine; 4D biomaterials; living materials; extracellular vesicle-based systems; advanced delivery systems; scalable manufacturing; translational medicine

(This special issue belongs to the Section Materials Science)

RNA Processing in Diseases

edited by

Naoyuki Kataoka

submission deadline 31 Oct 2026 | Viewed by 310 | Submission Open

Keywords: RNA splicing; alternative splicing; aberrant splicing; mis-splicing; RNA modification; RNA export; RNA processing; translation; mRNA stability

(This special issue belongs to the Section Molecular Genetics and Genomics)

Functional and Hybrid Imaging in Molecular Neuroscience

edited by Marija-Magdalena Petrinovic

submission deadline 31 Oct 2026 | Viewed by 302 | Submission Open

Keywords: molecular imaging; functional MRI; PET; multimodal brain imaging; neuroreceptor mapping; neuroinflammation; neurodegeneration; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Eco-Conscious Therapeutics: Molecular Foundations and Future Directions in Green Medicine

edited by

Adi Lahat

and

Kassem Sharif

submission deadline 31 Oct 2026 | Viewed by 293 | Submission Open

Keywords: green medicine; molecular therapeutics; sustainable healthcare; biomarker profiling; predictive toxicology; eco-friendly drug design; environmental impact; biodegradable materials

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Melanoma Resistance to Targeted Therapy

edited by

Ignacija Vlasic

and

Anđela Horvat

submission deadline 31 Oct 2026 | Viewed by 293 | Submission Open

Keywords: melanoma; targeted therapy; mechanisms of therapy resistance; predictive biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances on Gut Microbiota in Human Health

edited by

Sanda Cretoiu

submission deadline 31 Oct 2026 | Viewed by 290 | Submission Open

Keywords: gut microbiota; dysbiosis; metabolomics; host– microbe interaction; molecular pathways; inflammation; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Male Reproductive and Sexual Health

edited by

Aris Kaltsas

submission deadline 31 Oct 2026 | Viewed by 290 | Submission Open

Keywords: male reproductive health; male sexual health; male infertility; erectile dysfunction (ED); prostate inflammation; Peyronie's disease; biomarkers; molecular mechanisms; androgen deprivation; nanotechnology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neuroendocrine Tumors (NETs): New Molecular Insights

edited by Juan Pablo Petiti

submission deadline 31 Oct 2026 | Viewed by 288 | Submission Open

Keywords: neuroendocrine neoplasms; cell signaling; biomarkers; molecular targets; tumor progression; invasion

(This special issue belongs to the Section Molecular Oncology)

Allergy, Allergens and Therapeutics: Towards New Horizons

edited by

Luis Manuel Teran

and Gandhi Pavón-Romero

submission deadline 31 Oct 2026 | Viewed by 286 | Submission Open

Keywords: allergy; allergens; asthma; atopic dermatitis; urticaria; diagnostics; therapeutics; depemokimab; rimibrutinib; bazolvolimab

(This special issue belongs to the Section Molecular Immunology)

T Regulatory and NKT Cells as Prognostic Biomarkers in Inflammatory Disorders and Cancers

edited by

Elena Matei

submission deadline 31 Oct 2026 | Viewed by 276 | Submission Open

Keywords: immune response; Tregs; NKT; regulation pathways; prognostic biomarkers

(This special issue belongs to the Section Molecular Immunology)

Agro-Food Waste: From Bioactive Molecules to Materials

edited by

Natale Badalamenti

and

Antonella Maria Maggio

submission deadline 31 Oct 2026 | Viewed by 275 | Submission Open

Keywords: agro-food waste; phytochemistry; novel bio-products; physical– chemical characterization; innovative and sustainable extraction methodologies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antioxidant, Anti-Inflammatory and Anticancer Activities of Natural Products

edited by

Daeho Kwon

submission deadline 31 Oct 2026 | 1 articles | Viewed by 274 | Submission Open

Keywords: antioxidant; immunology; cancer; natural products; molecular biology; cell biology; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research on Natural Compounds: Biosynthesis, Analysis, and Application

edited by

Aleksandar Shkondrov

submission deadline 31 Oct 2026 | Viewed by 274 | Submission Open

Keywords: phytochemicals; natural compounds; chromatography; MS; NMR; analysis; identification; extraction; standardisation; quantitation; activity; moleabular mechanism; biosynthesis

(This special issue belongs to the Section Biochemistry)

Advances in Estrogen Therapy for CNS Diseases

edited by

Istvan Merchenthaler

submission deadline 31 Oct 2026 | Viewed by 272 | Submission Open

Keywords: estrogen; central nervous system (CNS) diseases; neurodegenerative disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Advances in Synaptic Transmission

edited by

Frank Schmitz

submission deadline 31 Oct 2026 | Viewed by 271 | Submission Open

Keywords: synapses; synaptic transmission; synaptic activity; neurological disease

(This special issue belongs to the Section Molecular Neurobiology)

The Expanding Genetic Landscape of Parkinson's Disease

edited by

Christos Koros

and

Vasilios C. Constantinides

submission deadline 31 Oct 2026 | Viewed by 266 | Submission Open

Keywords: Parkinson’ s disease; monogenic; polygenic risk score; alpha-synuclein

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Plant Abiotic Stress: Recent Advances and Challenges

edited by

Quaid Hussain

submission deadline 31 Oct 2026 | Viewed by 261 | Submission Open

Keywords: abiotic stress; plant stress tolerance; molecular mechanisms; gene expression; transcription factors; stress signaling pathways; functional genomics; plant hormones; omics technologies; gene family

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Legume Crop Breeding, Genetics, and Genomic Approaches

edited by

Duygu Sari

submission deadline 31 Oct 2026 | Viewed by 258 | Submission Open

Keywords: legume breeding; plant genetics; crop improvement; molecular breeding; genomic approaches; genetic diversity; abiotic stress tolerance; root system architecture; interspecific hybridization; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Progress of Cardiovascular and Metabolic Disease

edited by

Ilenia Calcaterra

submission deadline 31 Oct 2026 | Viewed by 249 | Submission Open

Keywords: cardiometabolic continuum; endothelial dysfunction; heart failure; metabolic complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Mineral Nutrition and Tolerance to Salt and Drought in Plants

edited by

Bruno Filipe Pereira de Sousa

submission deadline 31 Oct 2026 | Viewed by 237 | Submission Open

Keywords: ionic stress; water stress; salinity; mineral nutrition; uptake and transport; signalling and metabolism; plant-microbe interactions; tolerance mechanisms; plant physiology; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

Deciphering the Molecular Landscape of Thyroid Biology and Pathogenesis

edited by Cesar S. Fuziwara

submission deadline 31 Oct 2026 | Viewed by 235 | Submission Open

Keywords: thyroid cancer; thyroid diseases; gene regulation; signalling pathways; miRNA; lncRNAs; epigenetics; endocrine disruptors; thyroid development; animal models

(This special issue belongs to the Section Molecular Biology)

Mechanistic Insights into the Ubiquitin System’s Role in Cellular Signal Transduction and Homeostasis

edited by Michael Massiah

submission deadline 31 Oct 2026 | Viewed by 235 | Submission Open

Keywords: ubiquitination; protein homeostasis; deubiquitinases; E3-associated diseases; autophagy; ubiquitin dysregulation; proteasome-targeting; protac

(This special issue belongs to the Section Molecular Biology)

Adipose Tissue as a Central Driver of Obesity-Related Complications

edited by