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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Acute Leukemia: From Basic Research to Clinical Application, Second Edition

edited by

Luca Lo Nigro

submission deadline 20 Dec 2025 | Viewed by 153 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); acute myeloid leukemia (AML); genomic findings; post-genomic findings; targeted therapies; immunotherapies; novel markers

(This special issue belongs to the Section Molecular Oncology)

Proteases and Their Inhibitors: From Biochemistry to Applications

edited by

Gonzalo Izaguirre

submission deadline 20 Dec 2025 | Viewed by 152 | Submission Open

Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics

(This special issue belongs to the Section Molecular Biology)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Dec 2025 | Viewed by 151 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Cracking the Molecular Code of Breast Cancer

edited by Bartlomiej Taciak

submission deadline 20 Dec 2025 | Viewed by 146 | Submission Open

Keywords: breast cancer; TNBC; immunotherapy; microRNAs; NGS; therapeutics; biomarkers; epigenetics

(This special issue belongs to the Section Molecular Oncology)

Myosin: Structure, Function and Evolution

edited by Barbara Baryłko and

Joseph P. Albanesi

submission deadline 20 Dec 2025 | Viewed by 139 | Submission Open

Keywords: myosins; actin; molecular motors; organelle trafficking; endocytosis; secretion; membrane tension; RNA transport; force generation; ATPase activity

(This special issue belongs to the Section Macromolecules)

Molecular Basis of Inorganic Phosphate Transport Regulation in Protozoan Parasites

edited by

Jose Roberto Meyer-Fernandes

submission deadline 20 Dec 2025 | Viewed by 134 | Submission Open

Keywords: inorganic phosphate transport; protozoan parasites; cell proliferation

(This special issue belongs to the Section Molecular Biology)

Bioactives in Processed Foods: Profiling and Bioavailability Assessment

edited by Cong Wang

submission deadline 20 Dec 2025 | Viewed by 132 | Submission Open

Keywords: food processing; food bioactives; composition; bioavailability; functionality; novel food processing techniques; structure/constituents– bioactivity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Autophagic Related Proteins in Cancer

edited by Pietri Puustinen

submission deadline 20 Dec 2025 | Viewed by 130 | Submission Open

Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth

(This special issue belongs to the Section Molecular Oncology)

Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention

edited by

Jia-Feng Chang

and

Chih-Hsin Tang

submission deadline 20 Dec 2025 | Viewed by 101 | Submission Open

Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Molecular Research Advances in Metabolic Syndrome

edited by

Phileno Pinge-Filho

submission deadline 20 Dec 2025 | Viewed by 98 | Submission Open

Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular Life of Sperm: New Horizons in Male Infertility

edited by

Mónica Vazquez-Levin

and

Robert John Aitken

submission deadline 20 Dec 2025 | Viewed by 95 | Submission Open

Keywords: human sperm; fertilization; infertility; biomarkers; genetics

(This special issue belongs to the Section Molecular Biology)

Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration

edited by Seema Singh

submission deadline 20 Dec 2025 | Viewed by 85 | Submission Open

Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections

(This special issue belongs to the Section Molecular Immunology)

Molecular Research of Neonicotinoid Toxicity

edited by

Fatima Smagulova

submission deadline 20 Dec 2025 | Viewed by 78 | Submission Open

Keywords: neonicotinoids; sex-specific effects; brain– gut– microbiome; endocrine organs; genotoxic effects; epigenetic effects

(This special issue belongs to the Section Molecular Toxicology)

The Role of Ion Channels in Health and Disease

edited by

Joohyun Nam

submission deadline 20 Dec 2025 | Viewed by 70 | Submission Open

Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics

edited by

Vladimir N. Uversky

submission deadline 20 Dec 2025 | Viewed by 64 | Submission Open

Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography

(This special issue belongs to the Section Molecular Biophysics)

Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis, 2nd Edition

edited by

Subhasis B. Biswas

submission deadline 20 Dec 2025 | Viewed by 60 | Submission Open

Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology

(This special issue belongs to the Section Molecular Oncology)

Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 20 Dec 2025 | Viewed by 50 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Male Reproduction: Unveiling the Molecular Revolution

edited by

Anthony Archibong

submission deadline 20 Dec 2025 | Viewed by 46 | Submission Open

Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolomics of Medicinal Plants

edited by

L. Gerardo Zepeda Vallejo

and

Elvia Becerra-Martínez

submission deadline 20 Dec 2025 | Viewed by 46 | Submission Open

Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications

edited by

Mohammad El Khatib

submission deadline 20 Dec 2025 | Viewed by 45 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling

(This special issue belongs to the Section Molecular Biology)

Ongoing Anticancer Agents

edited by

Mauro Coluccia

submission deadline 20 Dec 2025 | Viewed by 43 | Submission Open

Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies

(This special issue belongs to the Section Molecular Oncology)

Intestinal Diseases and Gut Microbiota

edited by

Anna Duda-Madej

submission deadline 20 Dec 2025 | Viewed by 41 | Submission Open

Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developmental Origins of Kidney Disease: Renal Programming

edited by Hyung-Eun Yim

submission deadline 20 Dec 2025 | Viewed by 31 | Submission Open

Keywords: air pollution; chronic kidney disease; congenital anomalies of the kidneys and urinary tract; high-risk pregnancy; nephrogenesis; renal programming; renin angiotensin system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Gastrointestinal Cancer, 3rd Edition

edited by

Aneta Koronowicz

submission deadline 20 Dec 2025 | Viewed by 25 | Submission Open

Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis

(This special issue belongs to the Section Molecular Oncology)

Molecular Aspects of Tumor Radiotherapy

edited by

Johann Matschke

submission deadline 20 Dec 2025 | Viewed by 21 | Submission Open

Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies

(This special issue belongs to the Section Molecular Oncology)

Redox Physiology

edited by Mateusz Mołoń

submission deadline 21 Dec 2025 | Viewed by 302 | Submission Open

Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling

(This special issue belongs to the Section Molecular Biology)

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

edited by

Paschalis Karakasis

submission deadline 25 Dec 2025 | 1 articles | Viewed by 1093 | Submission Open

Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Skin Cancer: From Molecular Pathophysiology to Novel Treatment

edited by Soon-Hyo Kwon

submission deadline 25 Dec 2025 | 1 articles | Viewed by 556 | Submission Open

Keywords: basal cell carcinoma; malignant melanoma; molecular genetics; epigenetics; signaling pathways; tumor microenvironment; tumor resistance; biomarkers; molecular target; multiomics; genomics; transcriptomics; proteomics; metabolomics; skin cancer; squamous cell carcinoma

(This special issue belongs to the Section Molecular Oncology)

Molecular Endocrine Regulation in Health and Diseases

edited by Fady Hannah-Shmouni

submission deadline 25 Dec 2025 | 1 articles | Viewed by 350 | Submission Open

Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Spectroscopic Techniques in Molecular Sciences

edited by

Angela Staicu

submission deadline 25 Dec 2025 | 2 articles | Viewed by 317 | Submission Open

Keywords: spectroscopy; the structure; dynamics; interactions; and functions of molecules; chemical; biological; pharmaceutical; and materials systems

(This special issue belongs to the Section Molecular Biology)

Molecular and Genetic Advances in Plant Breeding

edited by Francesca Taranto

submission deadline 25 Dec 2025 | Viewed by 224 | Submission Open

Keywords: genetic diversity; next-generation sequencing; marker-assisted selection; GWAS/QTL mapping; KASP genotyping; molecular biology TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Plant Sciences)

Roots, Transporters, and Signals: Molecular Insights into Plant Mineral Nutrition and Heavy Metals Stress

edited by

Alessio Aprile

submission deadline 25 Dec 2025 | Viewed by 78 | Submission Open

Keywords: plant mineral nutrition; heavy metals; toxic element; transporter; signaling pathway

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights in Diabetes

edited by

Mariann Harangi

and

Ferenc Sztanek

submission deadline 25 Dec 2025 | Viewed by 75 | Submission Open

Keywords: insulin signalling pathway; pancreatic beta-cell dysfunction; oxidative stress; epigenetic modifications; metabolic memory; small regulatory RNAs (miRNAs); inflammation and insulin resistance; glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); molecular therapeutic targets; glucose homeostasis regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Insights into Tryptophan Metabolism

edited by

Katsunori Nonogaki

submission deadline 25 Dec 2025 | Viewed by 70 | Submission Open

Keywords: tryptophan; serotonin; kynurenine; indole; metabolism; IPA; Tph; IDO1; health; disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”

edited by

Julia Kzhyshkowska

submission deadline 25 Dec 2025 | Viewed by 45 | Submission Open

Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Immunology)

Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound

edited by Alicia Paz

submission deadline 25 Dec 2025 | Viewed by 23 | Submission Open

Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives

(This special issue belongs to the Section Molecular Microbiology)

Emerging Strategy in Bacterial Antibiotic Resistance

edited by Lili Li

submission deadline 28 Dec 2025 | Viewed by 29 | Submission Open

Keywords: fast detection; antimicrobial resistance; virulence; antibacterial action of natural compounds

(This special issue belongs to the Section Molecular Microbiology)

Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?

edited by

Dimitrios Kanakis

submission deadline 30 Dec 2025 | 5 articles | Viewed by 14539 | Submission Open

Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD）; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Neurobiological Mechanisms of Addictive Disorders

edited by Liliana Marina Cancela

submission deadline 30 Dec 2025 | 7 articles | Viewed by 13275 | Submission Open

(This special issue belongs to the Section Molecular Neurobiology)

Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition

edited by

King-Ho Cheung

submission deadline 30 Dec 2025 | 7 articles | Viewed by 10141 | Submission Open

Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology

edited by Ernesto Alejandro Aiello

submission deadline 30 Dec 2025 | 5 articles | Viewed by 9799 | Submission Open

Keywords: heart; vascular; signaling; cardiovascular disease; mechanism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Potential Prevention and Treatment of Neurodegenerative Disorders

edited by

Maria Paola Bertuccio

submission deadline 30 Dec 2025 | 5 articles | Viewed by 9276 | Submission Open

Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition

edited by

Ralf Kircheis

and

Oliver Planz

submission deadline 30 Dec 2025 | 7 articles | Viewed by 8887 | Submission Open

Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies

(This special issue belongs to the Section Molecular Immunology)

Recent Research on Hypertension and Related Complications

edited by

Marijn Speeckaert

submission deadline 30 Dec 2025 | 4 articles | Viewed by 8877 | Submission Open

Keywords: arterial hypertension; cardiovascular disease; pathophysiology; molecular mechanisms; complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Animal Research Model for Neurological Diseases, 2nd Edition

edited by

Giuseppe Montalbano

and

Sepand Rastegar

submission deadline 30 Dec 2025 | 4 articles | Viewed by 8815 | Submission Open

Keywords: experimental models; mouse; rat; zebrafish; neurological disease; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; neuroregeneration

(This special issue belongs to the Section Molecular Neurobiology)

Host-Pathogen Interaction, 6th Edition

edited by

Andreas Burkovski

submission deadline 30 Dec 2025 | 4 articles | Viewed by 8389 | Submission Open

Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms

(This special issue belongs to the Section Molecular Microbiology)

The Characterization and Application of Enzymes in Bioprocesses

edited by Loredana Marcolongo

submission deadline 30 Dec 2025 | 6 articles | Viewed by 7907 | Submission Open

Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing

(This special issue belongs to the Section Biochemistry)

Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition)

edited by

Rosaria Meccariello

submission deadline 30 Dec 2025 | 4 articles | Viewed by 6838 | Submission Open

Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Molecular Research on Autoimmune Diseases, 2nd Edition

edited by

Davide Cossu

submission deadline 30 Dec 2025 | 4 articles | Viewed by 6713 | Submission Open

Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Investigations in Neurodevelopmental Disorders

edited by Giorgio Medici

submission deadline 30 Dec 2025 | 6 articles | Viewed by 6047 | Submission Open

Keywords: neurodevelopmental disorders; brain; neurons; synapses; molecular research; regulatory networks; molecular pathways; biomarkers; therapies

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 2351-2400 on page 48 of 70.

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