From Molecular Mechanisms to Precision Medicine in Gastrointestinal Cancers: (Epi)genetics, Pharmacogenomics, and Emerging Biomarkers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 April 2026 | Viewed by 28
Special Issue Editor
Interests: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; Johne’s disease; gene regulation; biomarker
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastrointestinal (GI) cancers, which include colorectal, gastric, pancreatic, and hepatic malignancies, remain major causes of cancer-related morbidity and mortality worldwide. Although substantial progress has been made in understanding their molecular pathogenesis, translating these discoveries into effective clinical interventions continues to represent a pressing challenge.
This Special Issue, “From Molecular Mechanisms to Precision Medicine in Gastrointestinal Cancers: (Epi)Genetics, Pharmacogenomics, and Emerging Biomarkers”, will bring together work by basic scientists, translational researchers, and clinicians working to decipher the molecular determinants of GI tumor biology and their relevance to patient care.
We welcome original research, short communications, and reviews that explore the following topics:
- Genetic, epigenetic, and transcriptomic mechanisms underlying CRC and GI cancers;
- Translational and clinical studies that connect molecular findings to improved diagnostics, targeted therapies, or personalized treatment strategies;
- Integrative multi-omics and systems biology approaches to understanding tumor heterogeneity, signaling pathways, and immune interactions;
- Emerging molecular biomarkers and diagnostic technologies (liquid biopsy, ctDNA, exosomal markers, proteomics, and metabolomics) for early detection, prognosis, and therapy monitoring;
- Pharmacogenomics and therapeutic response mechanisms, including biomarkers predictive of drug sensitivity, resistance, or toxicity;
- Comparative studies in animal models with implications for human CRC;
- Computational and AI-driven models for molecular data integration and clinical decision support.
By fostering cross-disciplinary collaboration between laboratory researchers and clinical investigators, this Special Issue will accelerate the translation of mechanistic molecular discoveries to precision oncology for gastrointestinal cancers as a whole. We invite researchers from across a range of disciplines, including molecular biology, oncology, genomics, bioinformatics, and clinical medicine, to contribute their latest findings to this integrative effort.
Dr. Kostas A. Triantaphyllopoulos
Guest Editor
Manuscript Submission Information
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Keywords
- gastrointestinal and colorectal cancer
- genetic and epigenetic regulation
- multi-omics and computational biology
- molecular pathology and biomarker discovery
- translational and precision medicine
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