Molecular Research on Ischemia-Reperfusion Injury
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 531
Special Issue Editors
Interests: ischemia reperfusion models; anesthesic agents; pain models; Alzheimer's disease; sepsis; experimental diabetic models; ureter obstruction model; nanoparticules
Special Issue Information
Dear Colleagues,
Ischemia–reperfusion (IR) models are widely used to investigate the pathophysiological mechanisms underlying tissue injury caused by the temporary loss and subsequent restoration of blood flow. These models are commonly applied in organs such as the heart, brain, liver, and kidneys, using both in vivo and in vitro systems. Ischemia leads to oxygen and nutrient deprivation, resulting in metabolic imbalance, ATP depletion, and accumulation of toxic metabolites. Upon reperfusion, the sudden reintroduction of oxygen paradoxically exacerbates tissue damage through oxidative stress, inflammation, and cell death pathways.
Key mechanisms studied in IR models include the generation of reactive oxygen species, activation of inflammatory cascades, endothelial dysfunction, and mitochondrial impairment. Apoptosis, necrosis, and more recently described processes such as ferroptosis also contribute to cellular injury. Experimental models often involve controlled occlusion of blood vessels followed by reperfusion, allowing precise regulation of ischemic duration and severity.
These models are essential for evaluating potential therapeutic strategies, including antioxidant agents, anti-inflammatory drugs, ischemic preconditioning, and postconditioning techniques. Despite their value, limitations exist, such as differences between animal models and human physiology. Therefore, careful interpretation and translational validation are necessary. Overall, experimental IR models remain critical tools for advancing understanding and treatment of ischemic diseases.
Prof. Dr. Mustafa Arslan
Prof. Dr. Ayşegül Küçük
Guest Editors
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Keywords
- ischemia reperfusion models
- experimental models
- pre-post conditioning
- cell death pathways
- inflammation
- molecular mechanisms
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