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Antioxidant, Anti-Inflammatory and Anticancer Activities of Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 529

Editor

Department of Microbiology, College of Medicine, Catholic Kwandong University, Gangneung 25601, Republic of Korea
Interests: natural products; antioxidant; molecular biology

Special Issue Information

Dear Colleagues,

Natural products are increasingly recognized as valuable sources of bioactive compounds with antioxidant, anti-inflammatory, and anticancer properties. Derived from a variety of sources—including plants, microorganisms, marine organisms, and animals—natural products exhibit remarkable structural complexity and chemical diversity, making them an indispensable foundation for drug discovery and development. Thanks to their long-standing use in traditional medicine, combined with advances in modern analytical and biotechnological tools, researchers are continuing to discover new compounds with significant biomedical relevance. This Special Issue, “Antioxidant, Anti-Inflammatory and Anticancer Activities of Natural Products,” aims to highlight recent advances in the discovery, characterization, and biological evaluation of natural-product-derived compounds. Particular emphasis will be placed on studies exploring the diversity of natural products; their sources and biosynthesis; and their roles in biomedical research, including their potential as therapeutic agents or lead compounds for drug development. We invite researchers to submit original research articles related to bioactive natural products, their mechanisms of action, and potential therapeutic applications.

Dr. Daeho Kwon
Guest Editor

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Keywords

  • antioxidant
  • immunology
  • cancer
  • natural products
  • molecular biology
  • cell biology
  • secondary metabolites

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Published Papers (1 paper)

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Research

21 pages, 3220 KB  
Article
Gastroprotective Effects of Salvia plebeia via Antioxidant and MAPK/NF-κB-Mediated Anti-Inflammatory Mechanisms in Ethanol/HCl-Induced Gastric Injury
by Yun-seong Lee, Sunju So and Hyun-A Lee
Int. J. Mol. Sci. 2026, 27(10), 4358; https://doi.org/10.3390/ijms27104358 - 14 May 2026
Viewed by 391
Abstract
This study investigated the gastroprotective effects of Salvia plebeia extract (SPE) against acute gastric mucosal injury induced by 150 mM HCl/60% ethanol in rats and explored its antioxidant and anti-inflammatory mechanisms. SPE exhibited strong in vitro antioxidant activity, with DPPH and ABTS radical [...] Read more.
This study investigated the gastroprotective effects of Salvia plebeia extract (SPE) against acute gastric mucosal injury induced by 150 mM HCl/60% ethanol in rats and explored its antioxidant and anti-inflammatory mechanisms. SPE exhibited strong in vitro antioxidant activity, with DPPH and ABTS radical scavenging rates of 86.2 ± 2.4% and 89.1 ± 1.9%, respectively, along with a high total polyphenol content (96.4 ± 3.1 mg gallic acid equivalents/g extract). In lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, SPE attenuated LPS-induced inflammatory signaling, as evidenced by reduced TLR4 and JNK expression and restoration of IκBα levels. In vivo, oral administration of SPE (100 or 300 mg/kg) 1 h prior to HCl/ethanol challenge significantly reduced gastric lesion area and improved histopathological damage compared with the HCl/ethanol-treated control group. SPE also increased gastric pH, reduced gastric juice volume, decreased serum levels of TNF-α and IL-6, and downregulated gastric mucosal mRNA expression of Nos2 and Ptgs2. Immunohistochemical analysis further showed that SPE attenuated NF-κB p65 immunoreactivity in gastric tissues. Collectively, these findings suggest that SPE exerts gastroprotective effects through antioxidant activity and suppression of inflammatory responses associated with the MAPK/NF-κB pathway in acute HCl/ethanol-induced gastric injury. Full article
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