Molecular Targeted Therapy and Epigenetic Advances in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 207
Special Issue Editors
2. Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA
Interests: cancer immunology; immunotherapy; epigenetic regulation; AI genomics and AI medicine; single cell multi-omics; autoimmune and inflammatory diseases
2. Immunology Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI 48202, USA
Interests: langerhans cell biology; NKT cell biology; miRNAs
Special Issue Information
Dear Colleagues,
Epigenetic regulation is a critical driver of cancer onset, progression and treatment response. Cancer cells hijack transcriptional programs adapted for tumor survival under stress, thereby altering chromatin accessibility and adopting aberrant oncogenic transcriptional programs. These epigenetic circuits are strengthened by genetic and tumor heterogeneity, including mutations that amplify epigenetic signaling, histone marks, DNA methylation, noncoding RNA, and altered histone disposition.
This Special Issue, “Molecular Targeted Therapy and Epigenetic Advances in Cancer,” will focus on basic and translational studies that dissect fundamental mechanisms of epigenetic regulation in cancer. We encourage topics that define chromatin-based vulnerabilities and advance therapeutic strategies. Topics of interest include histone variants and their chaperones, DNA methylation and demethylation dynamics, chromatin accessibility and remodeling, noncoding RNA-mediated regulation, single-cell and spatial epigenomics, and mutations in epigenetic effectors.
Dr. Qing Sheng Mi
Dr. Li Zhou
Guest Editors
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Keywords
- cancer
- epigenetic
- therapeutic targets
- chromatin
- DNA methylation
- histone modification
- noncoding RNA
- histone variants
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