The Expanding Genetic Landscape of Parkinson's Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 25 March 2026 | Viewed by 18
Special Issue Editors
Interests: nerve; Parkinson’s disease; frontotemporal dementia spectrum disorders; cognitive functions impairment in PD;
Interests: progressive supranuclear palsy; multiple system atrophy; corticobasal syndrome; CSF biomarkers; MRI
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Parkinson’s disease (PD) represents a major cause of neurodegeneration, and its genetic component is increasingly recognized. Mendelian monogenic PD forms in cases with familial PD inheritance are a main research focus. Genotype-phenotype correlations have been described for pathogenic variants in autosomal dominant (including SNCA, LRRK2) or autosomal recessive PD-related genes (PRKN, PINK1, DJ-1). Furthermore, pathogenic variants in the Glucocerebrosidase gene (GBA1) represent a major genetic risk factor for PD with distinct clinical and biomarker features. The genetic diversity in patients of either Caucasian ancestry or underrepresented populations is in the spotlight of Parkinson’s disease research, to expand our knowledge of this complex disorder. Moreover, in sporadic PD, large genome-wide association studies (GWAS) and further analyses based on these data have enforced the idea of a substantial genetic contribution. Multiple susceptibility loci for sporadic PD have been identified, including the SNCA gene. In this Special Issue, we welcome authors to submit papers concerning the molecular and clinical advancements of the genetic aspect of PD.
Dr. Christos Koros
Dr. Vasilios C. Constantinides
Guest Editors
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Keywords
- Parkinson’s disease
- monogenic
- polygenic risk score
- alpha-synuclein
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