Male Reproductive and Sexual Health
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 11
Special Issue Editor
Interests: male infertility; non-obstructive azoospermia; sperm retrieval (micro-TESE/TESE); male reproductive tract microbiome; oxidative stress and inflammation; biomarkers and predictive models (including AI/ML); hypogonadism and testosterone therapy; translational and molecular urology/andrology
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Special Issue Information
Dear Colleagues,
Male reproductive and sexual health is central to well-being and fertility, yet it faces persistent clinical and public-health challenges, and recent reports suggesting declining semen quality in several populations have intensified interest in potentially modifiable risks and in earlier, prevention-oriented interventions.
Male factor infertility may account for a substantial share of infertility cases, but many presentations remain idiopathic despite standard evaluation. At the same time, advances in molecular profiling, imaging, bioengineering, and computational approaches are reshaping risk stratification, diagnosis, and treatment selection across male infertility and assisted reproduction.
Male sexual health disorders—including erectile dysfunction, chronic pelvic pain/prostatitis syndromes, hypogonadism, and fibrotic conditions such as Peyronie's disease—provide complementary translational models for vascular dysfunction, inflammation, endocrine signaling, and tissue remodeling. Mechanistic studies and biomarker-driven clinical research are needed to improve phenotyping and accelerate the development of targeted therapies.
In this context, this Special Issue of IJMS will gather together contributions that highlight molecular mechanisms, biomarkers, and translational advances in male reproductive and sexual health. The themes covered by this Special Issue align well with the scope of IJMS by emphasizing molecular biology and molecular medicine with clear clinical relevance in urology and andrology.
In this Special Issue, original research articles, reviews, and short communications are welcome, and research areas may include, but are not limited to, the following topics:
- Molecular mechanisms in male infertility (genetic, epigenetic, and transcriptomic regulation of spermatogenesis and sperm function);
- Biomarkers for erectile dysfunction and prostatic inflammation (molecular diagnostics, imaging-linked biomarkers, and endotypes);
- Translational models for Peyronie's disease and related fibrotic disorders (pathways, targets, and preclinical-to-clinic bridges);
- Novel therapies and nanotechnologies in male reproductive health (drug delivery, regenerative strategies, and emerging therapeutics);
- Molecular responses to testosterone and androgen deprivation (tissue-specific signaling, adverse effects, and mitigation strategies).
Dr. Aris Kaltsas
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- male reproductive health
- male sexual health
- male infertility
- erectile dysfunction (ED)
- prostate inflammation
- Peyronie's disease
- biomarkers
- molecular mechanisms
- androgen deprivation
- nanotechnology
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