Microenviromental Signalling in Tumorigenesis and Anti-Cancer Drugs Resistance
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 62
Special Issue Editor
2. ISOPROG-Somatolink EPFP Research Network, 93100 Caltanissetta, Italy
Interests: cancer biology; cell signaling; gene regulation; cancer-driving networks; pharmacogenomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The role of the tumor microenvironment in the induction, modulation, regulation, and conditioning of cancer’s evolution phases is well recognized and constantly revealing new molecular details. Understanding the complex interaction of the underlying cellular elements and the molecular signaling networks acting in the tumor microenvironment is at the core of many yet unanswered or partially answered questions such as the onset of actionable cancer-driving signals, the exact interaction between the immune system elements and cancer cells (or their cellular precursors), and how they differ within each cancer type and within an individual patient. In this context, new “Omics” technologies along with a growing number of computational tools have become available for interpreting the complexity originating at the single-cell level within the same studied biological specimen, disclosing a wider landscape and possible scenarios to be exploited at the therapeutic level.
Last but not least, the tumor microenvironment plays a critical role in determining the responsiveness, resistance, and potential recurrence of molecular target drugs and gene/cellular-mediated therapies (such as CAR-T). As a result, any basic, translational, and clinical study shedding new light on tumor-microenvironment-regulated signals is instrumental for the advancement of our cumulative understanding of cancer and how to effectively personalize present and future treatments.
Dr. Pierluigi Scalia
Guest Editor
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Keywords
- tumor microenvironment
- cancer cell signaling
- paracrine and autocrine mechanisms
- cancer drug resistance
- oncogenic pathways
- immune checkpoints
- cancer immune evasion
- cancer-associated fibroblasts
- tumor-infiltrating lymphocytes
- onco-immunology
- CAR-T
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