Molecular Insights into Role of Anthranilic Acid in Neuropsychiatric Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 1778
Special Issue Editor
Special Issue Information
Dear Colleagues,
As you are aware, dysregulations of tryptophan in the kynurenine pathway have been observed in neuropsychiatric disorders since the last century. However, anthranilic acid (AA), one of the downstream catabolites of kynurenine in humans and a tryptophan precursor in bacteria, did not attract much attention until about 10 years ago. AA was discovered to be involved in Alzheimer’s disease, schizophrenia, autism, bipolar disorder, major depressive disorder, post-partum depression, interferon alpha-induced depression, attention deficit disorders, migraines, cluster headaches, and psychiatric complications of COVID-19. The most recent suggestion is that AA, as a putative agonist of the G-protein-coupled receptor 109A, might open new perspectives in understanding AA’s involvement in pathogenesis and action mechanisms of pharmacological and non-pharmacological interventions, e.g., ECT and vagus nerve stimulation.
This issue is dedicated to presenting the most recent achievements in studies of anthranilic acid’s role in the pathogenesis of neuropsychiatric disorders, as well as the action mechanisms of pharmacological and non-pharmacological interventions and its potential as an early biomarker in neuropsychiatric disorders.
Prof. Dr. Gregory F. Oxenkrug
Guest Editor
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Keywords
- anthranilic acid
- Alzheimer’s disease
- autism
- schizophrenia
- bipolar disorder
- major depressive disorder
- post-partum depression
- COVID-19
- interferons
- attention deficit disorder
- cognitive impairment
- G-protein-coupled receptor 109A
- microbiome
- gut–brain axis
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