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Exploring Therapeutic Targets in the Evolving Landscape of Cancer Immunotherapy 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 35

Special Issue Editor


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Guest Editor
Hematology-Oncology and Stem Cell Transplantation Unit, Department of Hematology and Innovative Diagnostic, Istituto Nazionale Tumori-IRCCS-Fondazione “G. Pascale” Napoli, 80131 Napoli, Italy
Interests: dendritic cells; immunotherapy; gamma-delta T cells; cancer biomarkers; tumor immunology; cytometry
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Special Issue Information

Dear Colleagues,

Cancer immunotherapy has truly revolutionized oncology treatment, significantly enhancing patient survival rates. Recent strides in this field explore cutting-edge approaches, including personalized vaccines, combination therapies and advancements in CAR-T cell therapy, which are all aimed at elevating treatment specificity and overall effectiveness. Researchers are deeply engaged in unraveling the complexities of the tumor microenvironment, with a focus on modulating immunosuppressive factors and augmenting T-cell infiltration for optimal treatment outcomes. These advancements underscore a nuanced understanding of immune system dynamics within the context of cancer, paving the way for more sophisticated and impactful therapeutic strategies.

This Special Issue is dedicated to the exploration of cancer immunotherapy, with a specific focus on immune targets, CAR- and TCR-engineered T cell therapy for both blood and solid cancers, and malignancies associated with viral infections. It spans dynamic areas of research—including DC-based immunotherapy, Treg cell-mediated immunosuppression and innate immune signaling—offering a collection of innovative ideas aimed at enhancing therapeutic efficacy and broadening the application of immunotherapy for a diverse range of patients with cancer.

Dr. Domenico Galati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • immune checkpoints
  • targeted therapies
  • tumor microenvironment
  • cancer immunology
  • precision medicine
  • cell-based cancer therapy

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Published Papers

This special issue is now open for submission.
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