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The Impact of Oxidative Stress on Male and Female Germ Cells: From Redox Biology to Photon Emission

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 October 2026 | Viewed by 2939

Special Issue Editors


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Guest Editor
National Laboratory on Human Reproduction, Department of Obstetrics and Gynecology, University of Pecs, Pecs, Hungary
Interests: reproductive endocrinology; gynecology; human reproduction; maternal health
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
National Laboratory on Human Reproduction, Department of Obstetrics and Gynecology, University of Pecs, Pecs, Hungary
Interests: reproductive endocrinology; gynecology; human reproduction; embryonic development

Special Issue Information

Dear Colleagues,

Oxidative stress exerts profound effects on the function, integrity, and viability of both male and female germ cells. Reactive oxygen and nitrogen species (ROS/RNS) modulate gametogenesis, fertilization, and embryo development; however, excessive oxidative damage can lead to infertility, genomic instability, and transgenerational effects.

This Special Issue aims to explore the molecular and cellular mechanisms through which oxidative stress influences reproductive biology, integrating classical redox processes with emerging interdisciplinary perspectives such as bio-photon emission, oxidative metabolism-driven signaling, and quantum biological communication within germ cells and gametes.

We welcome original research articles and comprehensive reviews. Research areas may include (but are not limited to) the following:

  • Oxidative stress and redox signaling in gametogenesis;
  • Mitochondrial function and antioxidant defense mechanisms;
  • Environmental and metabolic sources of oxidative imbalance;
  • DNA damage, repair, and epigenetic modifications in germ cells;
  • Ultra-weak photon emission and oxidative metabolism;
  • Bio-photon communication and quantum biological processes;
  • Diagnostic and therapeutic approaches for redox-mediated infertility.

We look forward to receiving your contributions.

Prof. Dr. József Bódis
Dr. Kálmán András Kovács
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • germ cells
  • fertility
  • redox signaling
  • mitochondrial dynamics
  • DNA damage
  • photonic communication
  • ultra-weak photon emission
  • quantum biology
  • reproductive health

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Published Papers (1 paper)

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Review

17 pages, 2878 KB  
Review
Microplastics, Endocrine Disruptors, and Oxidative Stress: Mechanisms and Health Implications
by Kalman Kovacs, Jozsef Bodis and Reka A. Vass
Int. J. Mol. Sci. 2026, 27(1), 399; https://doi.org/10.3390/ijms27010399 - 30 Dec 2025
Cited by 8 | Viewed by 2454
Abstract
Microplastics and nanoplastics (<5 mm and <1 μm, respectively) are emerging contaminants now ubiquitous across environmental matrices and increasingly recognized for their impacts on human health. These particles commonly adsorb or contain endocrine-disrupting chemicals—such as bisphenol-A and phthalate additives—that together trigger complex biological [...] Read more.
Microplastics and nanoplastics (<5 mm and <1 μm, respectively) are emerging contaminants now ubiquitous across environmental matrices and increasingly recognized for their impacts on human health. These particles commonly adsorb or contain endocrine-disrupting chemicals—such as bisphenol-A and phthalate additives—that together trigger complex biological responses. This review examines the central role of oxidative stress in mediating the toxicity of microplastics and associated endocrine disruptors across multiple organ systems. We discuss mechanisms including cellular uptake, reactive oxygen species generation, mitochondrial dysfunction, impairment of antioxidant defenses, and activation of key signaling pathways. Organ-specific effects on reproductive health, cardiovascular function, hepatic metabolism, gut barrier integrity, and neurological systems are highlighted. Current evidence strongly supports oxidative stress as a pivotal mechanism linking microplastic exposure to systemic toxicity, underscoring important implications for public health policy and clinical intervention strategies. Full article
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