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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Latest Molecular Research on Renal Disease
edited by Niels Henrik Buus and Marco Eijken
submission deadline 30 Aug 2025 | 1 articles | Viewed by 645 | Submission Open
Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations submission deadline 30 Aug 2025 | 1 articles | Viewed by 541 | Submission Open
Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer
edited by
submission deadline 30 Aug 2025 | Viewed by 513 | Submission Open
Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer
(This special issue belongs to the Section Molecular Neurobiology)
Trees Genetics, Genomics, and Molecular Breeding
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 497 | Submission Open
Keywords: trees genetics; genomics; molecular; regulatory mechanism; genetic improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Plant Breeding
edited by , Sandra Correia and
submission deadline 30 Aug 2025 | 1 articles | Viewed by 445 | Submission Open
Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing
(This special issue belongs to the Section Molecular Plant Sciences)
Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 429 | Submission Open
Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules
(This special issue belongs to the Section Molecular Oncology)
Inflammation in Pregnancy and Childbirth
edited by and Maciej Ziętek
submission deadline 30 Aug 2025 | 1 articles | Viewed by 418 | Submission Open
Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins
(This special issue belongs to the Section Molecular Immunology)
Physics and Chemistry of Molecular Materials for Optoelectronic Applications submission deadline 30 Aug 2025 | Viewed by 418 | Submission Open
Keywords: polarization of matter; non-linear optics and non-linear optical phenomena; optical phenomena; quantum chemistry; density functional theory; physics and chemistry of molecular materials; molecular-based optoelectronics
(This special issue belongs to the Section Materials Science)
Role of Quorum Sensing in Plant Microbiome: Advances and Prospects
edited by
submission deadline 30 Aug 2025 | Viewed by 384 | Submission Open
Keywords: quorum sensing; quorum quenching; rhizosphere signaling; signaling molecules; N-Acyl-L-homoserine lactones; AHLs; microbiome; chemical molecules; sustainable agriculture
(This special issue belongs to the Section Molecular Plant Sciences)
Latest Advances in Computational Drug Discovery
edited by
submission deadline 30 Aug 2025 | Viewed by 368 | Submission Open
Keywords: design; synthesis; molecular docking; methodological reviews; novel docking approaches; ADME; toxicity; AI-driven molecular docking; molecular dynamics; bioisosteric replacement in drug design; rational drug design and synthesis; computational tools and algorithms; lead optimization and structure-based drug design; virtual screening of drug candidates; QSAR modelling; DFT
(This special issue belongs to the Section Molecular Pharmacology)
Novel Approaches for Tissue Repair and Tissue Regeneration
edited by Srinivas Madduri
submission deadline 30 Aug 2025 | 1 articles | Viewed by 353 | Submission Open
Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation: 3rd Edition submission deadline 30 Aug 2025 | 1 articles | Viewed by 317 | Submission Open
Keywords: atherosclerosis; coagulation; complement; endothelial cells; extracellular vesicles; fibrinolysis; immune thrombosis; inflammation; leukocytes; platelets; proteomics; red blood cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion
edited by
submission deadline 30 Aug 2025 | Viewed by 295 | Submission Open
Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Research on Nanosensors for Molecular Sensing Applications
edited by
submission deadline 30 Aug 2025 | Viewed by 186 | Submission Open
Keywords: nanostructure; microfabrication; nanoparticles; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; molecular recognition; biosensor; sensing mechanism; nanowires; affinity sensor
(This special issue belongs to the Section Molecular Nanoscience)
Application and Molecular Mechanisms of Microwaves for Materials Processing
edited by
submission deadline 30 Aug 2025 | Viewed by 185 | Submission Open
Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering
(This special issue belongs to the Section Materials Science)
Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures
edited by
submission deadline 30 Aug 2025 | Viewed by 183 | Submission Open
Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Mechanisms and Targeted Therapies for Leukemia
edited by
submission deadline 30 Aug 2025 | Viewed by 180 | Submission Open
Keywords: targeted therapy; acute myeloid leukemia; genetic mutations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Agrifood Waste Valorization: From By-Products to Sustainable Resources submission deadline 30 Aug 2025 | Viewed by 174 | Submission Open
Keywords: antioxidants; by-products; antimicrobials; nutraceuticals; food industry; circular economy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition
edited by
submission deadline 30 Aug 2025 | Viewed by 148 | Submission Open
Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity
(This special issue belongs to the Section Molecular Immunology)
Molecular Associations Between Adipose Tissue and Diseases submission deadline 30 Aug 2025 | Viewed by 145 | Submission Open
Keywords: lipedema; adipose tissue; adipocyte; adipose organ; body fat; miRNA; ketogenic diet
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery
edited by
submission deadline 30 Aug 2025 | Viewed by 143 | Submission Open
Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems
(This special issue belongs to the Section Molecular Biology)
Molecular Applications of Antioxidants and Anti-Inflammatory Activities of Natural Products submission deadline 30 Aug 2025 | Viewed by 139 | Submission Open
Keywords: antioxidants; anti-inflammatory agents; natural products; molecular mechanisms; oxidative stress; signaling pathways; inflammation; bioactive compounds; proteomics; metabolomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in Primary Colorectal Cancer and Liver Metastases
edited by Alexandros E. Giakoustidis
submission deadline 30 Aug 2025 | Viewed by 136 | Submission Open
Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Lipoprotein in Cardiovascular Disease submission deadline 30 Aug 2025 | Viewed by 135 | Submission Open
Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Type 2 Diabetes and Its Complications: 2nd Edition
edited by
submission deadline 30 Aug 2025 | Viewed by 132 | Submission Open
Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Progress in Biological and Molecular Mechanisms and Targeted Therapies of Leukemia
edited by Anna Sicuranza
submission deadline 30 Aug 2025 | Viewed by 130 | Submission Open
Keywords: leukemia-targeted therapies; AML; CML; venetoclax combination therapy; tyrosine kinase inhibitors (TKIs); hypomethylating agents; ALL; CLL; CAR-T cell therapy; monoclonal antibodies; immune checkpoint inhibitors; resistance mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Osteoarthritis Pathways and Biomarker Research
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 125 | Submission Open
Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Heavy Metal Exposure on Health
edited by
submission deadline 30 Aug 2025 | Viewed by 125 | Submission Open
Keywords: heavy metals; toxic metal exposure; oxidative stress; mitochondrial dysfunction; epigenetic alterations; physiological and molecular pathways of cellular toxicology; biomarkers of toxicity; chelating agents; antioxidants; therapies or treatments
(This special issue belongs to the Section Molecular Toxicology)
Microbial Pathogens and Drug Resistance in the Environment
edited by
submission deadline 30 Aug 2025 | Viewed by 125 | Submission Open
Keywords: antibiotics; peptides; chemotherapeutics; antimicrobial drugs; molecular mechanism of drug action
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances in Brain Plasticity submission deadline 30 Aug 2025 | Viewed by 124 | Submission Open
Keywords: neurophysiology; neurobiology; synapses; synaptic plasticity; microglia; astrocytes; dendritic spines; neurodevelopment; neurodevelopmental disease; learning and memory; neuropharmacology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics
edited by
submission deadline 30 Aug 2025 | Viewed by 122 | Submission Open
Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Behind Plant–Virus Interactions: Pathogenesis and Defense submission deadline 30 Aug 2025 | Viewed by 121 | Submission Open
Keywords: plant viruses; plant resistance; plant signaling; plant defense; biotic stress; plant– virus interactions; molecular mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis
edited by
submission deadline 30 Aug 2025 | Viewed by 120 | Submission Open
Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Treatment in Skin Cancer
edited by
submission deadline 30 Aug 2025 | Viewed by 120 | Submission Open
Keywords: skin cancer; early detection; treatment; prevention; pathophysiology; vitamin-C; cell energetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
RNA-Based Regulation in Human Health and Disease submission deadline 30 Aug 2025 | Viewed by 120 | Submission Open
Keywords: non-coding RNAs (ncRNAs); small nucleolar RNAs (snoRNAs); long non-coding RNAs (lncRNAs); microRNAs (miRNAs); piwi-interacting RNAs (piRNAs); circular RNAs (circRNAs); RNA modifications (m6A; pseudouridylation); RNA-protein interactions; post-transcriptional gene regulation; RNA interference (RNAi); antisense oligonucleotides (ASOs); RNA-binding proteins (RBPs); epitranscriptomics; RNA-based therapeutics; cancer-associated ncRNAs; neurodegenerative diseases and RNA regulation; cardiovascular RNA biology; metabolic disorders and RNA; ribosomal RNA modifications; RNA-targeted drug discovery
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioactive Peptides: Microbial Fermentation-Driven Synthesis and Multifunctional Applications in Health and Industry
edited by
submission deadline 30 Aug 2025 | Viewed by 115 | Submission Open
Keywords: bioactive peptides; foods; probiotics; fermentation; pharmaceutical; herbs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cancer Biology and Epigenetic Modifications
edited by Tamer E. Fandy
submission deadline 30 Aug 2025 | Viewed by 112 | Submission Open
Keywords: epigenetics; DNA methylation; epigenetic modifiers; histone acetylation; histone methylation; miRNA; ncRNA; chrmoatin remodelling
(This special issue belongs to the Section Molecular Oncology)
Application of Large Language Models in Bioinformatics: Deep Exploration from Protein to Gene Networks
edited by Dukka B. Kc
submission deadline 30 Aug 2025 | Viewed by 111 | Submission Open
Keywords: large language models; protein language models; DNA language model; RNA language model; deep learning; bioinformatics; protein structure; sequence alignment; prediction of gene; protein function; gene networks
(This special issue belongs to the Section Molecular Informatics)
Electron or Ion Transport in Electrochemistry
edited by Simone Sanna
submission deadline 30 Aug 2025 | Viewed by 108 | Submission Open
Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Ruminant Physiology: Digestion, Metabolism, and Endocrine System
edited by Rui Hu
submission deadline 30 Aug 2025 | Viewed by 108 | Submission Open
Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular and Cellular Research on Cardiac Repair and Regeneration submission deadline 30 Aug 2025 | Viewed by 105 | Submission Open
Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling
(This special issue belongs to the Section Molecular Biology)
The Toxicity of Bisphenol A and Its Analogs
edited by
submission deadline 30 Aug 2025 | Viewed by 104 | Submission Open
Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology
(This special issue belongs to the Section Molecular Toxicology)
Transgenic Mouse Models in Human Disease Research in Epithelial Tissues: Insights and Advances submission deadline 30 Aug 2025 | Viewed by 104 | Submission Open
Keywords: transgenic animals; kideny diseases; heart failure; cystic diseases
(This special issue belongs to the Section Molecular Biology)
Molecular and Histological Approaches in Oral Tissue Regeneration and Diagnostics
edited by
submission deadline 30 Aug 2025 | Viewed by 104 | Submission Open
Keywords: dentistry; histological analysis; immunofluorescence; molecular pathogenesis; tissue
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liquid Biopsies in Oncology—3rd Edition submission deadline 30 Aug 2025 | Viewed by 103 | Submission Open
Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles
(This special issue belongs to the Section Molecular Oncology)
Health Targeting Cardiovascular and Cerebrovascular Diseases: Molecular Aspects
edited by
submission deadline 30 Aug 2025 | Viewed by 103 | Submission Open
Keywords: cardiovascular disease; cerebrovascular disease; cell therapy; gene therapy; extracellular vesicles; regenerative medicine; brain– heart axis; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment submission deadline 30 Aug 2025 | Viewed by 99 | Submission Open
Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment
(This special issue belongs to the Section Molecular Oncology)
Molecular Advancements in Functional Materials
edited by
submission deadline 30 Aug 2025 | Viewed by 99 | Submission Open
Keywords: synthesis of specialty compounds; specialty compounds in functional materials; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.; properties; special-purpose functional materials
(This special issue belongs to the Section Materials Science)
Phytochemicals in Health and Disease: From Molecular Mechanisms to Evidence-Based Applications
edited by Olga Silva
submission deadline 30 Aug 2025 | Viewed by 99 | Submission Open
Keywords: phytochemicals; bioactive natural products; medicinal plants; chronic and inflammatory diseases; ethnopharmacology and phytotherapy
(This special issue belongs to the Section Molecular Biology)
Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fourth Edition
edited by
submission deadline 30 Aug 2025 | Viewed by 97 | Submission Open
Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
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