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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms Behind Plant–Virus Interactions: Pathogenesis and Defense

edited by

Katarzyna Otulak-Kozieł

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1451 | Submission Open

Keywords: plant viruses; plant resistance; plant signaling; plant defense; biotic stress; plant– virus interactions; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development

edited by Gabriela Verónica Salamone

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1447 | Submission Open

Keywords: gliomas tumor microenvironment immune

(This special issue belongs to the Section Molecular Oncology)

Cell–Cell Communication Through Extracellular Vesicles

edited by

Federica Fratini

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1426 | Submission Open

Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape

(This special issue belongs to the Section Molecular Biology)

Molecular Research on PRDM Genes

edited by

Erika Zazzo

Ciro Abbondanza

and

Monica Rienzo

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1365 | Submission Open

Keywords: PRDM; cancer; gene expression regulation; epigenetic modifications; proliferation; differentiation; gene expression regulation; apoptosis; cancer biomarkers; cancer diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Development of Responsive Nanoparticles for Cancer Therapy, 3rd Edition

edited by

Jordi Puiggalí

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1365 | Submission Open

Keywords: nanoparticles; liposomes; polymersomes; micelles; surface functionalization; cell targeting; stimuli-sensitivity; drug delivery; therapeutic applications; diagnostic applications; cancer treatment

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Forensics at Trial

edited by

Guido Viel

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1360 | Submission Open

Keywords: forensic science; molecular biology; evidence; proof; justice; trial; forensic pathology; forensic genetics; forensic histology; forensic toxicology

(This special issue belongs to the Section Molecular Toxicology)

New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery: 2nd Edition

edited by Fei Guo

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1293 | Submission Open

Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications

(This special issue belongs to the Section Molecular Informatics)

Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition

edited by

Deguo Han

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1265 | Submission Open

Keywords: plant– pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Neurodegenerative Diseases Research and Therapy, Fourth Edition

edited by

Sumonto Mitra

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1261 | Submission Open

Keywords: neurodegenerative diseases; therapy; molecular mechanisms; neuron; astrocytes; microglia; inflammation; brain; drug delivery

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Genomic Basis of Viral Variation and Host Adaptation

edited by In Ohk Ouh

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1230 | Submission Open

Keywords: viral genome evolution mutation and selection dynamics; structure– function relationships of viral proteins; immune evasion; regulatory mechanisms; comparative viral genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Pathogenesis and Novel Therapeutic Targets in Oncologic Cardiotoxicity

edited by

Marco Tana

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1171 | Submission Open

Keywords: cardiotoxicity; CTRCD; heart failure; HFrEF; HFpEF

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Transplantation: Pathogenesis, Therapeutic Strategies and Future Challenges

edited by

Francesco Tandoi

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1170 | Submission Open

Keywords: MASLD; transplant oncology; machine perfusion; extended-criteria donors; donors after cardiac death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Product and Enzyme Inhibition for Disease Management

edited by

Viet Phong Nguyen

and

Le Ba Vinh

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1153 | Submission Open

Keywords: bioactive compounds; natural sources; enzyme inhibition; drug discovery; cancer; cardiovascular diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress

edited by

Maria Giulia Lionetto

and

Maria Elena Giordano

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1077 | Submission Open

Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways

(This special issue belongs to the Section Molecular Toxicology)

The Application of Stem Cells in Regenerative Medicine

edited by

Marina Gazdic Jankovic

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1054 | Submission Open

Keywords: embryonic stem cells; induced pluripotent stem cells; adult stem cells; cancer stem cells; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies

edited by

Katarzyna Romanowska-Próchnicka

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1053 | Submission Open

Keywords: molecular mechanisms; immune signaling pathways; targeted therapies; biomarkers; autoimmune pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physiology and Pathophysiology of Neurodegeneration: New Insights and Advances from Molecular to Cellular Level

edited by

Alessandro Romano

and

Amilcare Barca

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1047 | Submission Open

Keywords: central and peripheral nervous systems; neuron homeostasis; neurodegeneration; neurodegenerative disease; neurophysiology; -omic technologies; induced pluripotent stem cell (iPSC); three-dimensional cell culture; organ-on-a-chip (OoC)

(This special issue belongs to the Section Molecular Neurobiology)

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition

edited by

Michael C. Levin

submission deadline 31 Jul 2026 | 1 articles | Viewed by 976 | Submission Open

Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis

(This special issue belongs to the Section Molecular Immunology)

Molecularly Engineered Nanomaterials for Energy Conversion, Storage, and AI-Driven Materials Discovery

edited by

Atanu Jana

submission deadline 31 Jul 2026 | 1 articles | Viewed by 960 | Submission Open

Keywords: molecular engineering; energy conversion and storage; hydrogen evolution reaction (HER); oxygen evolution reaction (OER); batteries and supercapacitors; optical properties; light-emitting diodes; AI-assisted materials design

(This special issue belongs to the Section Molecular Nanoscience)

Drug Development and Discovery for Alzheimer's Disease

edited by Martha Cecilia Rosales-Hernández

submission deadline 31 Jul 2026 | 1 articles | Viewed by 956 | Submission Open

Keywords: Alzheimer's disease; drug design; repurposed molecules; therapeutic targets; amyloid-β ; β -secretase; acetylcholin-esterase; in silico studies; oxidative stress; chemical synthesis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Neuro-Ophthalmology

edited by

Toshiyuki Oshitari

submission deadline 31 Jul 2026 | 1 articles | Viewed by 952 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Nanoparticle Toxicity: Beyond Chemical Composition—the Critical Role of Physicochemical Properties

edited by

Karen Khachatryan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 887 | Submission Open

Keywords: nanotoxicology; engineered nanomaterials; physicochemical properties; risk assessment; reactive oxygen species (ROS); protein corona; cellular uptake; regulatory science; safe-by-design

(This special issue belongs to the Section Molecular Toxicology)

Advancements in Cytopathology: Challenges and Changes

edited by Panagiota Mikou

submission deadline 31 Jul 2026 | 1 articles | Viewed by 859 | Submission Open

Keywords: cytopathology; cancer diagnosis; cytology; early cancer detection; exfoliative cytology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapeutic Strategies in Gastrointestinal Cancer

edited by

Pedro Luiz Serrano Usón Júnior

submission deadline 31 Jul 2026 | 1 articles | Viewed by 815 | Submission Open

Keywords: gastrointestinal cancers; pancreatic cancer; gastric cancer; colorectal cancer; hepatobiliary cancers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Red Blood Cells in Health and Disease

edited by Annamaria Russo and Ester Tellone

submission deadline 31 Jul 2026 | Viewed by 803 | Submission Open

Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes

(This special issue belongs to the Section Biochemistry)

Eukaryotic Mitogenomes: Key Insights

edited by

Yuri Kartavtsev

submission deadline 31 Jul 2026 | 1 articles | Viewed by 767 | Submission Open

Keywords: eukaria; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations

(This special issue belongs to the Section Molecular Biology)

New Insights into Antimicrobial Peptides with Anticancer Activity

edited by

Esther Imperlini

submission deadline 31 Jul 2026 | 1 articles | Viewed by 743 | Submission Open

Keywords: antimicrobial peptides; cytotoxicity; selective anticancer drugs; omics approaches; anticancer peptide action

(This special issue belongs to the Section Biochemistry)

Recent Advances in Neuroprotective Drug Development and Therapeutic Applications

edited by Jolanta Helena Kotlińska

submission deadline 31 Jul 2026 | 1 articles | Viewed by 743 | Submission Open

Keywords: neuropharmacology; neuroprotective drugs; dopaminergic and glutamatergic signaling; endocannabinoid system; neurodevelopmental and stress-related disorders

(This special issue belongs to the Section Molecular Neurobiology)

Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies

edited by Osha Roopnarine

submission deadline 31 Jul 2026 | Viewed by 734 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Gangliosides

edited by

Sandro Sonnino

and

Massimo Aureli

submission deadline 31 Jul 2026 | 1 articles | Viewed by 714 | Submission Open

Keywords: gangliosides; sphingolipids; plasma membrane; lysosomes; glycohydrolases; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular Research of Facial Adipose Compartments

edited by Marius Valeriu Hînganu

submission deadline 31 Jul 2026 | Viewed by 700 | Submission Open

Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing

(This special issue belongs to the Section Molecular Biology)

The Latest Research in Intestinal Inflammation and Immunity

edited by

Gabriela Fonseca-Camarillo

and

Jesús Yamamoto-Furusho

submission deadline 31 Jul 2026 | 2 articles | Viewed by 686 | Submission Open

Keywords: ulcerative colitis; mucins; inflammation; immunoregulation; T cells; B cells; Crohn’ s disease; cytokines

(This special issue belongs to the Section Molecular Immunology)

Functional and Regulatory Cancer Genomics

edited by

Apostolos Zaravinos

submission deadline 31 Jul 2026 | 1 articles | Viewed by 683 | Submission Open

Keywords: cancer genomics; functional genomics; regulatory genomics; epigenetics; transcriptomics; non‑coding RNAs; single‑cell genomics; multi‑omics; tumor heterogeneity; precision oncology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Post-Transcriptional Gene Regulation of mRNA and Protein Expression

edited by Greco Hernández

submission deadline 31 Jul 2026 | 1 articles | Viewed by 676 | Submission Open

Keywords: translational control; protein synthesis; mRNA biochemistry; signal transduction; mTOR pathway; post-transcriptional regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Emerging Insights into Phytohormone Signaling in Plants—2nd Edition

edited by Meng Zhang

submission deadline 31 Jul 2026 | 1 articles | Viewed by 652 | Submission Open

Keywords: phytohormone; signal transduction; evolutionary and functional diversity; implications for plant science and agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Physiopathology and Therapeutics of HIV Infection

edited by

Inês Bártolo

submission deadline 31 Jul 2026 | Viewed by 630 | Submission Open

Keywords: HIV; physiopathology; ART; HAART; NRTIs; NNRTIs; PIs; INSTIs; fusion inhibitors; CCR5 antagonists; post-attachment inhibitors; capsid inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computer-Aided Drug Discovery: Computational Chemistry and Cheminformatics

edited by

Daniel Glossman-Mitnik

submission deadline 31 Jul 2026 | 2 articles | Viewed by 624 | Submission Open

Keywords: computer-aided drug discovery; computational chemistry; cheminformatics; conceptual density functional theory (CDFT); molecular docking; molecular dynamics simulations; QSAR/QSPR modeling; ADMET prediction; machine learning in drug design

(This special issue belongs to the Section Molecular Informatics)

Mechanistic Insights into Next-Generation Psychobiotics

edited by

Qi Su

submission deadline 31 Jul 2026 | 1 articles | Viewed by 618 | Submission Open

Keywords: gut– brain axis; psychobiotics; next-generation psychobiotics; microbiota; probiotics; postbiotics; microbial metabolites

(This special issue belongs to the Section Molecular Microbiology)

Molecular Characterization and Utilization of Plant Genetic Resources

edited by

Roel Rabara

submission deadline 31 Jul 2026 | 1 articles | Viewed by 609 | Submission Open

Keywords: molecular markers; genetic resources; genomics; transcriptomics; molecular characterization; genetic diversity; transcriptomics; bioinformatics; germplasm enhancement; epigenetics

(This special issue belongs to the Section Molecular Plant Sciences)

Roadmap of the Human Epigenome: Insights from RNAs

edited by

Maria Samara

submission deadline 31 Jul 2026 | 1 articles | Viewed by 607 | Submission Open

Keywords: human epigenome; non-coding RNAs; RNA-mediated regulation; transcriptomics; diagnostics and therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomic and Proteomic Advances in Tracking Antibiotic Resistance Evolution

edited by

Vanessa Natália dos Santos Silva

submission deadline 31 Jul 2026 | Viewed by 588 | Submission Open

Keywords: antibiotic resistance; genomic; proteomic; one health

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Plant–Microbe Interactions

edited by

Daowan Lai

submission deadline 31 Jul 2026 | 1 articles | Viewed by 527 | Submission Open

Keywords: plant– microbe interactions; plant defense; pathogenicity; genetics; biochemistry; artificial intelligence; synthetic biology; symbiosis; plant protection

(This special issue belongs to the Section Molecular Plant Sciences)

Anti-Inflammatory Drugs: New and Old Compounds with Novel Delivery Systems Contributing to Improve the Treatment of Inflammatory Diseases

edited by S. Gorzalczany

submission deadline 31 Jul 2026 | 1 articles | Viewed by 490 | Submission Open

Keywords: inflammation; new compounds; novel formulation; mechanism of action; biological drug; arthritis; inflammatory bowel disease

(This special issue belongs to the Section Molecular Biology)

The Role of Lipids in Health and Diseases: 2nd Volume

edited by

Yutang Wang

submission deadline 31 Jul 2026 | 1 articles | Viewed by 490 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Translational Roles of Regulatory Enzyme Superfamilies in Physiology and Disease

edited by

Clemente Capasso

submission deadline 31 Jul 2026 | 1 articles | Viewed by 486 | Submission Open

Keywords: enzyme mechanisms; regulatory enzyme superfamilies; protein structure– function relationship; enzyme regulation and signaling; disease-associated enzymes; translational enzymology

(This special issue belongs to the Section Biochemistry)

New Advances in Protein Analysis in Disease

edited by

Valeria Magnelli

submission deadline 31 Jul 2026 | 1 articles | Viewed by 482 | Submission Open

Keywords: proteomics; protein; profile; molecular mechanism; biomarker; therapeutical agent

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms in Action of Hormones

edited by

Chirine Toufaily

submission deadline 31 Jul 2026 | Viewed by 471 | Submission Open

Keywords: G-protein coupled receptors; bias signaling; neuromodulators; nuclear receptors; small molecules; hormonal crosstalk; endocrine stressors; cell-cell communication; gene expression; spatial transcriptomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Green Gold: Microalgae as a Sustainable Source of Nutrients and Bioactive Compounds

edited by

Blanca Hernández-Ledesma

and Pilar Gómez-Cortés

submission deadline 31 Jul 2026 | Viewed by 469 | Submission Open

Keywords: microalgae; sustainable nutrition; bioactive compounds; functional foods; nutraceuticals; alternative proteins; phycochemistry; circular bioeconomy; biorefinery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Advances in Targeted Molecular Therapies for Genetic Disease

edited by Viorica-Elena Rădoi

submission deadline 31 Jul 2026 | 1 articles | Viewed by 463 | Submission Open

Keywords: genetic diseases; precision medicine; gene editing; RNA-based therapeutics; genomic profiling; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Aptamers in Cancer Therapy: Mechanisms, Applications, and Translational Perspectives

edited by

Gabor István Csonka

submission deadline 31 Jul 2026 | Viewed by 463 | Submission Open

Keywords: aptamers; targeted drug delivery; cancer immunotherapy; molecular imaging; biomarkers; precision oncology; SELEX; theranostics; translational oncology; mechanistic insights

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 851-900 on page 18 of 65.

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