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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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CRISPR/Cas Systems and Genome Editing—3rd Edition

edited by

Dmitry Karpov

submission deadline 25 Aug 2025 | Viewed by 150 | Submission Open

Keywords: CRISPR/Cas; bacterial argonauts; transcription regulation; genome editing; genome editing tools

(This special issue belongs to the Section Molecular Genetics and Genomics)

Obesity: Different Perspectives Based on Molecular Physiology and Pathology

edited by Hector I. Rocha-Gonzalez

submission deadline 25 Aug 2025 | Viewed by 145 | Submission Open

Keywords: obesity; rational management; perspectives; new ideas; pharmacology; lifestyle modification; molecular advances

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Treatments of Diabetes Mellitus: 2nd Edition

edited by

Mihail Virgil Boldeanu

submission deadline 25 Aug 2025 | Viewed by 144 | Submission Open

Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Degradable Polymers: Synthesis, Applications, and Environmental Impact

edited by Ce Sun and

Haiyang Gao

submission deadline 25 Aug 2025 | Viewed by 141 | Submission Open

Keywords: degradable polymer; synthesis; degradation mechanisms; sustainability

(This special issue belongs to the Section Macromolecules)

Molecular Research on Dyslipidemia

edited by

Aleksandra Zeljkovic

and

Jelena Vekić

submission deadline 25 Aug 2025 | Viewed by 134 | Submission Open

Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Regulators of Bone Health

edited by

Akkouch Adil

submission deadline 25 Aug 2025 | Viewed by 127 | Submission Open

Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in the Role of Retinoic Acid-Regulated Genes in Cancer Biology

edited by Fuming Tsai

submission deadline 25 Aug 2025 | Viewed by 89 | Submission Open

Keywords: retinoic acid; retinoic acid receptors; retinoic x receptors; tumorigenesis; metastasis; tumor microenvironment; molecular pathways

(This special issue belongs to the Section Molecular Genetics and Genomics)

Neuromodulatory Effects of Serotonin, 2nd Edition

edited by

Yasemin M. Akay

submission deadline 25 Aug 2025 | Submission Open

Keywords: neuromodulation; Serotonin; pain research; cognition; emotions; depression; anxiety; GBM

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Lung Cancer: From Genetic Landscape to Treatment

edited by Rossella Bruno

submission deadline 26 Aug 2025 | 1 articles | Viewed by 2423 | Submission Open

Keywords: lung cancer; precision medicine; predictive biomarkers; resistance mechanisms; targeted therapy; immunotherapy; molecular tests; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Recent Research on Optoelectronic Materials

edited by

Meysam Tayebi

submission deadline 28 Aug 2025 | Viewed by 213 | Submission Open

Keywords: photoelectrochemistry; optoelectronic materials; perovskite materials; semiconductor interfaces; molecular-level catalysis; solar fuel conversion; nanostructured materials; light-harvesting systems

(This special issue belongs to the Section Materials Science)

Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes

edited by

Sungtae Koo

submission deadline 28 Aug 2025 | Viewed by 175 | Submission Open

Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Molecular Pharmacology of Neurological Diseases

edited by

Chian Ju Jong

submission deadline 28 Aug 2025 | Viewed by 154 | Submission Open

Keywords: neurological diseases; neurodevelopmental disorders; neurodegenerative diseases; therapeutic agents; drug discovery; molecular pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

The Neuro and Immune Mechanisms Behind Cannabinoids Effects

edited by

Babak Baban

submission deadline 28 Aug 2025 | Viewed by 102 | Submission Open

Keywords: cannabinoids; neuroinflammation; endocannabinoid system (ECS); non-cannabinoid receptors; immune modulation; synaptic plasticity

(This special issue belongs to the Section Biochemistry)

Molecular Biology of Plant Disease Resistance

edited by Heewan Kang

submission deadline 28 Aug 2025 | Viewed by 98 | Submission Open

Keywords: Bacillus subtilis; antifungal activity; amino acids; defense genes; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Immune Regulation During Pregnancy

edited by Sabrina Marie Scroggins

submission deadline 28 Aug 2025 | Viewed by 73 | Submission Open

Keywords: maternal– fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome

(This special issue belongs to the Section Molecular Immunology)

Molecular Biomarkers for Assessing Marine Ecosystem Health

edited by

Maria Costantini

Valerio Zupo

and

Roberta Esposito

submission deadline 28 Aug 2025 | Viewed by 68 | Submission Open

Keywords: biodiversity; biomarkers; biomonitoring; marine organisms; pollution; metals; microplastics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-Inflammatory and Anti-Oxidant Effects of Extracts from Plants

edited by

Sheila Leone

and

Lucia Recinella

submission deadline 29 Aug 2025 | 1 articles | Viewed by 865 | Submission Open

Keywords: oxidative stress; inflammation; herbal extracts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Application and Formulation of Therapeutic Natural Deep Eutectic Solvents

edited by

Kunn Hadinoto Ong

submission deadline 29 Aug 2025 | Viewed by 111 | Submission Open

Keywords: deep eutectic solvent; ionic liquid drug; eutectic mixture; green solvent; pharmaceutical salts

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Thrombosis

edited by

J. Kh. Khizroeva

submission deadline 30 Aug 2025 | 6 articles | Viewed by 16498 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on the Role of the Gut Microbiota in Human Diseases and Health

edited by

Sanda Cretoiu

submission deadline 30 Aug 2025 | 5 articles | Viewed by 13610 | Submission Open

Keywords: microbiota; microbiome; gut microbiome metabolites; dysbiosis; gut– organ axis; gut microbiota pathogens; diet

(This special issue belongs to the Section Molecular Microbiology)

The Role of Extracellular Vesicles in Cancer Diagnosis and Therapy, 2nd Edition

edited by

Nils Ludwig

submission deadline 30 Aug 2025 | 3 articles | Viewed by 7338 | Submission Open

Keywords: extracellular vesicles; exosomes; intercellular communication; liquid biopsy; cancer therapeutics; nanotherapeutics

(This special issue belongs to the Section Molecular Oncology)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 30 Aug 2025 | 4 articles | Viewed by 5721 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

From Bench to Bedside: Well-Established and Emerging Preclinical Models in Cardiovascular Research

edited by

Laura Calvillo

and Veronica Dusi

submission deadline 30 Aug 2025 | 1 articles | Viewed by 5420 | Submission Open

Keywords: myocardial infarction; organ ischemia and reperfusion injury; hypertension; cardiovascular dysfunction; cardio-renal syndrome; stroke; arrhythmias; heart disease; heart failure; genetic disorders; translational medicine; organoids; bioreactors; organs on a chip; omics sciences; pharmacology; molecular biology; gene therapy; quantum biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Germline Stem Cells: New Insights

edited by

Thomas Skutella

submission deadline 30 Aug 2025 | 1 articles | Viewed by 4301 | Submission Open

Keywords: signaling pathway; spermatogonia development; oocyte development; microarray analysis; single-cell sequencing; epigenetic mechanisms; germline stem cell

(This special issue belongs to the Section Molecular Biology)

Immunology of Infectious Disease and Transplantation: A Symbiotic Dance

edited by

Alessandro Perrella

submission deadline 30 Aug 2025 | 2 articles | Viewed by 3994 | Submission Open

Keywords: organ transplantation; infectious disease; immune responses; immunology; personalized medicine; transplantation medicine

(This special issue belongs to the Section Molecular Immunology)

Genetic Analysis Based on CRISPR/Cas9 Technology: 2nd Edition

edited by

Yong-Gu Cho

and

Kwon-Kyoo Kang

submission deadline 30 Aug 2025 | 2 articles | Viewed by 3487 | Submission Open

Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Transition Metal Catalysis: From Synthesis to Late-Stage Functionalization of Aromatics and Heterocycles

edited by

Antonio Del Vecchio

and

Fabio Bellina

submission deadline 30 Aug 2025 | 2 articles | Viewed by 3242 | Submission Open

Keywords: transition metal catalysis; homogeneous catalysis; heterogeneous catalysis; cross-couplings; synthesis of aromatics and heteroaromatics; late-stage functionalization; photo-; electro-; flow; mechanochemistry; medicinal chemistry; material sciences; bioinorganic chemistry; industrial processes

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2257 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2222 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

Oral Soft Tissue Repair and Oral Diseases: 2nd Edition

edited by

Jacek Matys

submission deadline 30 Aug 2025 | 2 articles | Viewed by 2181 | Submission Open

Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Biology)

The Extracellular Matrix in Physiopathology

edited by

Eric Huet

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2037 | Submission Open

Keywords: extracellular matrix; glycosaminoglycans; matrix metalloproteinases; tissue remodeling; cell interactions; physiopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Plasticity and EMT in Cancer and Fibrotic Diseases

edited by

Sabrina Lisi

and

Margherita Sisto

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1992 | Submission Open

Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1451 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1308 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

Beyond the Known: Molecular Insights into the World of New Psychoactive Compounds

edited by

Helena Gaspar

and

Rita Pacheco

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1256 | Submission Open

Keywords: new psychoactive substances; synthetic drugs; metabolism; toxicology; drug checking; designer drugs

(This special issue belongs to the Section Macromolecules)

Intracellular Trafficking and Catabolism of Free Heme: Physiological Roles and Relevance to Pathological Mechanisms

edited by Junichi Taira

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1155 | Submission Open

Keywords: heme oxygenase; heme metabolism; heme chaperon; free heme (labile heme); cytochrome P450 reductase; reactive oxygen species; carbon monoxide

(This special issue belongs to the Section Biochemistry)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1116 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Plants Redox Biology

edited by

Xin Li

submission deadline 30 Aug 2025 | 1 articles | Viewed by 961 | Submission Open

Keywords: plant– environment interaction; stress physiology; plant redox signaling; plant hormones; plant– pathogen interaction; reactive oxygen species (ROS); reactive nitrogen species (RNS); ascorbate; flavonoid; glutathione

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Endothelial Cell Injury and Repair

edited by

Eleni Gavriilaki

and

Panagiota Anyfanti

submission deadline 30 Aug 2025 | 1 articles | Viewed by 893 | Submission Open

Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Microbe Interaction: Current Status and Future Directions

edited by

Juan Manuel Ruiz Lozano

submission deadline 30 Aug 2025 | Viewed by 843 | Submission Open

Keywords: beneficial micro-organism; climate change; crop productivity; environmental stress; food production; plant growth; stress mitigation; yield

(This special issue belongs to the Section Molecular Plant Sciences)

Innovative Technologies in the Study and Understanding of Colorectal Tumorigenesis: Challenges and Opportunities

edited by

Paola Sena

submission deadline 30 Aug 2025 | 1 articles | Viewed by 810 | Submission Open

Keywords: colorectal cancer; genetic analysis; gut microbiome; tumor; circulating components; medicine; immunotherapy; proteomics

(This special issue belongs to the Section Molecular Oncology)

Biodegradable Polymers: From Chemical Synthesis to Biodegradable Mechanism

edited by

Ling-Ping Xiao

Oana Lelia Pop

and

Gabrijel Ondrasek

submission deadline 30 Aug 2025 | Viewed by 766 | Submission Open

Keywords: biodegradable polymers; polyolefins; molecular structures; synthesis; chemical modification; hydrolysis kinetics

(This special issue belongs to the Section Macromolecules)

Advances in Computer-Aided Drug Design Strategies

edited by

Alexandre G. De Brevern

submission deadline 30 Aug 2025 | 1 articles | Viewed by 764 | Submission Open

Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Regenerative Medicine and Therapeutics

edited by Diana Torge

submission deadline 30 Aug 2025 | 1 articles | Viewed by 743 | Submission Open

Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Molecular Research on Renal Disease

edited by Niels Henrik Buus and Marco Eijken

submission deadline 30 Aug 2025 | 1 articles | Viewed by 655 | Submission Open

Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gastrointestinal Microbes: Implications for Health and Disease

edited by Suqin Hang

submission deadline 30 Aug 2025 | 1 articles | Viewed by 654 | Submission Open

Keywords: animal; gut; microbiota; gut hormone; nutrients

(This special issue belongs to the Section Molecular Microbiology)

The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations

edited by

Ioannis-Dimosthenis Adamakis

and

Kosmas Haralampidis

submission deadline 30 Aug 2025 | 1 articles | Viewed by 544 | Submission Open

Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer

edited by

Yutang Wang

submission deadline 30 Aug 2025 | Viewed by 513 | Submission Open

Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer

(This special issue belongs to the Section Molecular Neurobiology)

Trees Genetics, Genomics, and Molecular Breeding

edited by

Hengfu Yin

submission deadline 30 Aug 2025 | 1 articles | Viewed by 510 | Submission Open

Keywords: trees genetics; genomics; molecular; regulatory mechanism; genetic improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Plant Breeding

edited by