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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Cancer and Cell Metabolism—2nd Edition

edited by

Maria Concetta Faniello

Maria Mesuraca

and

Barbara Quaresima

submission deadline 30 Dec 2025 | 7 articles | Viewed by 9658 | Submission Open

Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Therapeutic Innovations in Neurodegenerative Diseases: 2nd Edition

edited by Melania Maria Serafini and

Nicoletta Marchesi

submission deadline 30 Dec 2025 | 4 articles | Viewed by 9654 | Submission Open

Keywords: Alzheimer’ s disease; strokes; multiple sclerosis; amyotrophic lateral sclerosis; polyneuropathies; pain; diabetic retinopathy; neuroinflammation; dietary supplements; microbiome

(This special issue belongs to the Section Molecular Neurobiology)

Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine

edited by

Ramya Lakshmi Rajendran

and

Prakash Gangadaran

submission deadline 30 Dec 2025 | 3 articles | Viewed by 9104 | Submission Open

Keywords: regenerative medicine; pluripotent stem cells; cell differentiation; tissue engineering; gene editing; therapeutic potential; clinical applications; neurodegenerative disorders; disease modeling

(This special issue belongs to the Section Molecular Biology)

Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition)

edited by

Rosaria Meccariello

submission deadline 30 Dec 2025 | 4 articles | Viewed by 8451 | Submission Open

Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Pathogenicity and Antibiotic Resistance of Helicobacter pylori

edited by

Paweł Krzyżek

submission deadline 30 Dec 2025 | 2 articles | Viewed by 8347 | Submission Open

Keywords: Helicobacter pylori; antibiotic resistance; antibiotic tolerance; point mutations; efflux pumps; biofilm formation; coccoid forms; membrane vesicles; virulence factors

(This special issue belongs to the Section Molecular Microbiology)

Mitochondrial Biology and Human Diseases

edited by

Francesco Bruni

and

Paola Loguercio Polosa

submission deadline 30 Dec 2025 | 4 articles | Viewed by 8065 | Submission Open

Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases

(This special issue belongs to the Section Molecular Biology)

Genetic and Molecular Mechanisms of Obesity

edited by

Maria Elisabeth Street

and

Giuseppina Rosaria Umano

submission deadline 30 Dec 2025 | 3 articles | Viewed by 8046 | Submission Open

Keywords: obesity; insulin signal transduction; insulin sensitivity; co-morbidities; genetics; epigenetics; miRNAs; DNA methylation; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research on Autoimmune Diseases, 2nd Edition

edited by

Davide Cossu

submission deadline 30 Dec 2025 | 4 articles | Viewed by 7877 | Submission Open

Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Chromatin Remodelers as Players and Drivers in Pathological States

edited by Matteo De March

submission deadline 30 Dec 2025 | 3 articles | Viewed by 7357 | Submission Open

Keywords: protein structure/function; chromatin remodelers; DNA repair; oncogene/oncosuppressor; cancer

(This special issue belongs to the Section Molecular Biology)

Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Lorenzo Belluomini

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6602 | Submission Open

Keywords: NSCLC; predictive and prognostic biomarkers; immunotherapy; targeted therapy; special populations

(This special issue belongs to the Section Molecular Oncology)

IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals

edited by

Maurizio Battino

submission deadline 30 Dec 2025 | 6 articles | Viewed by 6596 | Submission Open

Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Omics Technologies in Molecular Biology

edited by

Andrés J. Cortés

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6413 | Submission Open

Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology

edited by

Shu Yuan

submission deadline 30 Dec 2025 | 5 articles | Viewed by 6342 | Submission Open

Keywords: bacteria fungi; bacteriophages; microalgae; microbiome; gut microbiota; environmental microbiome; microbiome– brain– gut axis; virus– host interactions; emerging viruses re-emerging viruses; virus mutation; biofilm antimicrobial; SARS-CoV-2 (COVID-19)

(This special issue belongs to the Section Molecular Microbiology)

Plant and Environmental Interactions (Abiotic Stress)

edited by

Lixin Li

submission deadline 30 Dec 2025 | 5 articles | Viewed by 6255 | Submission Open

Keywords: stress response; signal transduction; metabolism and secondary metabolism; material/vesicle transportation; rhizospheric microorganism; interactions between plants and microorganisms

(This special issue belongs to the Section Molecular Plant Sciences)

Biophysical Perspectives on Bone Physiology and Pathology

edited by Atsuhiko Ichimura and Yohei Ueda

submission deadline 30 Dec 2025 | 1 articles | Viewed by 6144 | Submission Open

Keywords: bone formation; bone disorders; physiology; pathology; stem cells; osteoblasts; osteoclasts

(This special issue belongs to the Section Molecular Biophysics)

Molecular Pathogenesis and Therapies for Retinal and Optic Nerve Diseases

edited by

Toshiyuki Oshitari

submission deadline 30 Dec 2025 | 1 articles | Viewed by 6095 | Submission Open

Keywords: neurovascular unit; neurovascular cell death; neuroprotection; vasoprotection; regeneration; molecular and cellular pathologies; current and future therapies; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Phenolic Accumulation and Application in Human Diseases

edited by

Izabela Grzegorczyk-Karolak

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6039 | Submission Open

Keywords: antioxidant effects; anticancer/antiproliferative activity; anti-inflammatory activity; antimicrobial effects bioactive polyphenols; chemical identification of plant compounds; chemistry and mechanisms of action; health beneficial effect; medicinal plant; molecular targets; natural products; phytochemicals; structure– activity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Bone Development and Differentiation in Health and Disease

edited by

Cristina Sánchez-De-Diego

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5678 | Submission Open

Keywords: bone differentiation; signaling pathways; bone diseases; bone formation; osteoblast; osteocyte; osteoclast

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Effect of Food-Derived Compounds on Brown Fat Cell Function

edited by

Nobuyuki Takahashi

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5658 | Submission Open

Keywords: brown adipocyte; beige adipocyte; nutrients; food-derived components; thermogenesis; energy homeostasis; inflammation; obesity; diabetes; insulin resistance; metabolic syndrome; adipokines; lipid and carbohydrate metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Influence of Environmental Factors on Disease and Health Outcomes

edited by

Piotr Kaminski

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5296 | Submission Open

Keywords: environmental factors; ecophysiological determinations; genetic predispositions; gene expression; defensive responses; pathophysiological abnormalities; lifestyle diseases; polymorphisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies

edited by

Hongqun Liu

submission deadline 30 Dec 2025 | 4 articles | Viewed by 5233 | Submission Open

Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis

edited by

Regina M. Day

and Jeffrey R. Koenitzer

submission deadline 30 Dec 2025 | 3 articles | Viewed by 4739 | Submission Open

Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins

(This special issue belongs to the Section Molecular Biology)

Reproductive Toxicity of Chemicals

edited by

Maria Laura Zenclussen

submission deadline 30 Dec 2025 | 5 articles | Viewed by 4574 | Submission Open

Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure

(This special issue belongs to the Section Molecular Toxicology)

Immune Regulation and T Cell Dynamics

edited by Tatiana Akimova

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4572 | Submission Open

Keywords: autoimmunity; T cells; FOXP3; Treg; regulatory T cells; transplantation; tolerance; T cell activation; exhaustion; T cell-mediated immunity; T cell immunotherapy

(This special issue belongs to the Section Molecular Immunology)

The Role of Extracellular Matrix in Cancer

edited by

José M. Muñoz-Félix

submission deadline 30 Dec 2025 | 1 articles | Viewed by 4521 | Submission Open

Keywords: extracellular matrix; cancer; collagen; integrins; metastasis

(This special issue belongs to the Section Molecular Oncology)

Plant Natural Products for Human Health and Disease

edited by

Rumyana Simeonova

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4302 | Submission Open

Keywords: medicinal plants; phytochemistry; bioactive compounds; metabolomics; proteomics; antioxidants; signal transduction; immunomodulation; phytopharmacology; ethnopharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments

edited by

Joan Torras-Ambròs

and Juliana Bordignon-Draibe

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3706 | Submission Open

Keywords: primary glomerular diseases; membranous nephropathy; IgA nephropathy; glomerular inflammatory mechanisms; aberrantly glycosylated IgA1; galactose-deficient IgA1 (Gd-IgA1); alternative complement pathway; C5; factor B; factor D; APRIL; BAFF; phospholipase A2 receptor (PLA2R); thrombospondin type I domain-containing 7A (THSD7A); exostosins 1 and 2 (EXT1/2); neural epidermal growth factor-like 1 protein (NELL-1); semaphorin 3B (Sema3B); neural cell adhesion molecule 1 (NCAM1)

(This special issue belongs to the Section Molecular Immunology)

Heart Failure: From Molecular Mechanisms to Clinically Translational Innovations

edited by

Carmela Rita Balistreri

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3307 | Submission Open

Keywords: heart failure; pathophysiology; cellular and molecular mechanisms; traditional biomarkers: limits and benefits; emerging molecular biomarkers; innovative therapies; i.e.; personalized therapies; targeted therapies; etc.; the application of artificial intelligence; multi-omics technologies; imaging innovative biomarkers; clinical translation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurogenetic Disorders: Neurogenetics, Pathogenesis, and Gene Therapy

edited by

Paschalis Theotokis

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3093 | Submission Open

Keywords: precision medicine; gene therapy; neurogenetics; rare monogenic diseases; inherited nervous system disorders; mitochondrial diseases (e.g.; LHON; MELAS); lysosomal storage disorders (e.g.; Tay– Sachs; Gaucher); hereditary neuropathies (e.g.; CMT; hATTR); motor neuron diseases (e.g.; SMA; ALS); spinocerebellar ataxias (e.g.; SCA); biomarkers in neurology

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Genetic Research on Psychiatric Disorders

edited by Lawrence Shih-Hsin Wu

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2990 | Submission Open

Keywords: genetics; bipolar disorder; schizophrenia; major depressive disorder; autism; substance abuse; genomics

(This special issue belongs to the Section Molecular Neurobiology)

Insights into Mitochondrial Iron Metabolism: Connections to Cancer and Other Pathologies

edited by Michael Petronek

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2968 | Submission Open

Keywords: iron metabolism; mitochondrial iron; cellular homeostasis; iron– sulfur cluster biogenesis; heme synthesis; mitochondrial ferritin; cancer biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2924 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition

edited by

Livio Giuliani

Pierre Madl

and

Nikolaj Sorgenfrei Blom

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2874 | Submission Open

Keywords: quantum sciences; radiation biology; biomedical applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Neuroimmune Axis in Cancer and Inflammatory Diseases

edited by

Patrick Ming-Kuen Tang

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2801 | Submission Open

Keywords: neuro-immune axis; cancer progression; drug resistance; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in the Pathogenesis and Treatment of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2501 | Submission Open

Keywords: heart failure; biomarkers; pathways of heart failure; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology

edited by

Giuseppe Murdaca

and

Sebastiano Gangemi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2407 | Submission Open

Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition

edited by

Edyta Zbroch

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2389 | Submission Open

Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms of Diabetic Cardiomyopathy

edited by Martin Michel

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2364 | Submission Open

Keywords: diabetes; cardiomyopathy; animal models; novel treatments; pathophyiology; SGLT2 inhibitors; neprilysin inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Strategies in Cancer Therapy

edited by

Paolo Coghi

and

Carmine Coluccini

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2300 | Submission Open

Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression

(This special issue belongs to the Section Molecular Oncology)

Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine

edited by

Satya Prakash

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2282 | Submission Open

Keywords: polymer-based nanoparticles; lipid nanoparticles; PLGA and chitosan nano/microparticles for gene therapy; targeted drug delivery; nucleic acid-loaded nanoparticles; siRNA nanoparticles; nanoparticle-mediated mirna delivery; nanoparticles in cancer therapy; nanoparticles in vaccine design; nanoparticle-mediated gene therapy

(This special issue belongs to the Section Molecular Pharmacology)

Plant Stress Biology

edited by Rui Li

submission deadline 30 Dec 2025 | 3 articles | Viewed by 2138 | Submission Open

Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

New Advances in Cancer Stem Cell Research: 2nd Edition

edited by

Tomoyasu Sugiyama

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2132 | Submission Open

Keywords: cancer stem cell; biomarker; signaling; cancer-associated fibroblast; artificial intelligence; cell therapy; antibody therapy; cell therapy; gene expression

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Anti-Cancer Drugs, 2nd Edition

edited by

Christiana Neophytou

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1964 | Submission Open

Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Advances in the Pathophysiology and Treatment of Eye Diseases

edited by

Georgios Panos

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1716 | Submission Open

Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dietary Antioxidants in Human Health

edited by

Marika Cordaro

Roberta Fusco

and

Rosanna Di Paola

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1710 | Submission Open

Keywords: diet; functional food; oxidative stress; mitochondrial disfunction; human health; animal models; nutrition; molecular pathways; human pathology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Lectins

edited by Yuichiro Sato

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1639 | Submission Open

Keywords: lectin; carbohydrate-binding specificity; virus; antiviral activity; cancer; anticancer activity; glycan-targeted therapy

(This special issue belongs to the Section Molecular Biology)

Stroke: Novel Molecular Mechanisms and Therapeutic Approaches

edited by Kang-Ho Choi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1631 | Submission Open

Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Luisa M. P. F. Amaral

and

Romeu A. Videira

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1607 | Submission Open

Keywords: natural bioactive compounds; discovery and isolation; chemical characterization; biological activities; mechanisms of action; pharmaceuticals; nutraceuticals; agricultural applications; cosmetic innovations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences

edited by

Andrei Smertenko

submission deadline 30 Dec 2025 | 4 articles | Viewed by 1505 | Submission Open

Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential

edited by

Rachel Shukrun

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1370 | Submission Open

Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 801-850 on page 17 of 69.

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