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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Red Blood Cells in Health and Disease
edited by Annamaria Russo and Ester Tellone
submission deadline 25 Jun 2025 | Viewed by 314 | Submission Open
Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes
(This special issue belongs to the Section Biochemistry)
Effects of Xenobiotic Exposure on Human Health: A Molecular Perspective submission deadline 25 Jun 2025 | Viewed by 270 | Submission Open
Keywords: xenobiotic exposure; human health; toxic effects; environmental chemicals; molecular research
(This special issue belongs to the Section Molecular Toxicology)
Hormonal and Metabolic Markers in Health and Disease submission deadline 25 Jun 2025 | Viewed by 148 | Submission Open
Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Protection of Natural Products in Liver Injury
edited by
submission deadline 27 Jun 2025 | Viewed by 84 | Submission Open
Keywords: liver injury; natural product; antioxidant activity; modulation of inflammatory pathway; mitigation of fibrosis; pharmacology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)
edited by
submission deadline 28 Jun 2025 | 1 articles | Viewed by 1326 | Submission Open
Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes
(This special issue belongs to the Section Molecular Plant Sciences)
Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds
edited by and
submission deadline 28 Jun 2025 | 1 articles | Viewed by 558 | Submission Open
Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches
edited by
submission deadline 28 Jun 2025 | Viewed by 97 | Submission Open
Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways
(This special issue belongs to the Section Molecular Oncology)
Exploring the Molecular, Physiological, and Biochemical Responses of Crops to Stress
edited by
submission deadline 29 Jun 2025 | 4 articles | Viewed by 2197 | Submission Open
Keywords: molecular signaling pathways in response to biotic stresses (e.g.; bacteria; viruses; fungi; and insects); plant responses to abiotic stresses (e.g.; salinity; cold; drought; waterlogging; heat; heavy metals; and UV light); mechanisms of stress adaptation and tolerance; stress adaptation
(This special issue belongs to the Section Molecular Plant Sciences)
Development and Validation of New Analytical Methods for the Determination of Drugs and Their Metabolites
edited by
submission deadline 29 Jun 2025 | 1 articles | Viewed by 398 | Submission Open
Keywords: drugs; drug formulations; pharmacokinetics; metabolism studies; analytical techniques
(This special issue belongs to the Section Molecular Pharmacology)
Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis
edited by and Jeffrey R. Koenitzer
submission deadline 29 Jun 2025 | Viewed by 110 | Submission Open
Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins
(This special issue belongs to the Section Molecular Biology)
Rare Diseases and Neuroscience submission deadline 30 Jun 2025 | 7 articles | Viewed by 17767 | Submission Open
Keywords: neurogenetics; rare diseases; rare neurological diseases; cerebellar ataxia; rare movement disorders; mitochondrial diseases; innovative treatments in rare neurological diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetics and Novel Techniques for Soybean Pivotal Characters
edited by and
submission deadline 30 Jun 2025 | 9 articles | Viewed by 17287 | Submission Open
Keywords: QTL mapping and marker-assisted selection; GWAS and genomic selection/prediction; molecular breeding by design; germplasm application; domestication and selection signatures; genotype x environment interaction; improvement of seed quality and/or nutritional quality traits; nitrogen efficiency modification; symbiosis mechanism detection; breeding for tolerance to biotic stresses; soybean– pathogen interaction; increasing the adaptation to the environment
(This special issue belongs to the Section Molecular Plant Sciences)
G Protein-Coupled Receptors
edited by
submission deadline 30 Jun 2025 | 7 articles | Viewed by 17276 | Submission Open
Keywords: biased signaling; activation microswitches; allosteric ligands; drug design; GPCR-targeted assays; compound profiling; orphan receptors; viral hijacking of GPCRs; cellular response; live-cell imaging
(This special issue belongs to the Section Molecular Biology)
State-of-the-Art Molecular Neurobiology in Poland
edited by
submission deadline 30 Jun 2025 | 6 articles | Viewed by 17006 | Submission Open
Keywords: neurobiology; neurochemistry; neuropathology; neurophysiology; neuropharmacology; neurogenetics; neurodegeneration; aging neuroscience; neurogenesis; neuroplasticity; signalling pathways; signalling networks; systems biology; stress-related processes
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insight into Retinal Diseases
edited by Hsiaoming Chao, Robert Casson and Hsi-Kung Kuo
submission deadline 30 Jun 2025 | 8 articles | Viewed by 16250 | Submission Open
Keywords: faricimab; modified cerebrolysin; acupuncture; stem cells; gene therapy; retinal chip; femtosecond; artisan aphakia; artiflex; exozyme; silicon oil; amniotic membrane; EOG; multifocal ERG; flash ERG; VEP; microperimetry; OCT-A
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Molecular Science of Fragile X Syndrome and Associated Disorders
edited by Flora Tassone and Randi Hagerman
submission deadline 30 Jun 2025 | 12 articles | Viewed by 12223 | Submission Open
Keywords: FMR1; fragile X syndrome; FXPOI; FXTAS; FXAND; FXPAC; molecular studies
(This special issue belongs to the Section Molecular Biology)
Plant Omics: Sensing, Signaling, Regulation and Homeostasis submission deadline 30 Jun 2025 | 5 articles | Viewed by 10657 | Submission Open
Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology
(This special issue belongs to the Section Molecular Plant Sciences)
Breast Cancer: Molecular Pathology, Diagnosis, and Therapeutic Strategies
edited by Rodrigo Sánchez-Bayona
submission deadline 30 Jun 2025 | 5 articles | Viewed by 10080 | Submission Open
Keywords: biomarker; breast; molecular assays; molecular characterization; molecular-driven treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mechanisms of Heavy Metal Toxicity: 3rd Edition
edited by
submission deadline 30 Jun 2025 | 6 articles | Viewed by 7848 | Submission Open
Keywords: heavy metal; metal compound; metallothionein; cellular defense mechanism; metal transporter
(This special issue belongs to the Section Molecular Toxicology)
Understanding the Genetics of Complex Traits in Plants: Association Analysis and Genomic Selection Methods
edited by
submission deadline 30 Jun 2025 | 9 articles | Viewed by 7731 | Submission Open
Keywords: association analysis; genomic selection; plant; complex trait; genetic architecture; molecular biology; molecular breeding; genotype– environment interaction
(This special issue belongs to the Section Molecular Plant Sciences)
Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration 4.0 submission deadline 30 Jun 2025 | 5 articles | Viewed by 7626 | Submission Open
Keywords: mesenchymal stem cells (MSCs); regenerative medicine; tissue engineering; tissue repair; cell differentiation; cell behaviour and cell fate; traslational medicine; animal sources; MSC vesicles; MSC secretome; MSCs as genetic vectors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis, Characterization and Phyto-Function of Nanophotocatalysts submission deadline 30 Jun 2025 | 3 articles | Viewed by 7289 | Submission Open
Keywords: nanophotocatalysts; green synthesis; hydrogen generation; pollutants; fine chemistry; photoinactivation; cancer; microorganisms
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Structure and Function of Intermediate Filaments in Health and Disease submission deadline 30 Jun 2025 | 2 articles | Viewed by 6595 | Submission Open
Keywords: intermediate filaments; vimentin; peripherin; lamins; keratins; neurofilaments; mechanics; migration; signaling; autophagy; organelle positioning; organelle function; inflammation; neurodegenerative diseases; cancer; gene expression; epigenetics; post-translational modifications
(This special issue belongs to the Section Molecular Biology)
RNA Biology and Regulation
edited by
submission deadline 30 Jun 2025 | 6 articles | Viewed by 5938 | Submission Open
Keywords: RNA processing; RNA transport; RNA localization; RNA editing; RNA synthesis; RNA stability; RNA modification; translation; transcription; RNA metabolism; human diseases
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Role of Lipids in Health and Diseases
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 5914 | Submission Open
Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Glioblastoma Pathogenesis: Focus on Progenitor Cells, Microglia and Noncoding RNA
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 5876 | Submission Open
Keywords: glioblastoma; tumor microenvironment; microglia; tumor-infiltrating lymphocytes; astrocytes; progenitor cells; driver mutations
(This special issue belongs to the Section Molecular Oncology)
Multifunctional Application of Biopolymers and Biomaterials 2.0
edited by
submission deadline 30 Jun 2025 | 4 articles | Viewed by 5307 | Submission Open
Keywords: biopolymers; nanomaterials; biomaterials; functional materials; bioactive natural compounds; essential oil emulsion; natural colorant; plant extract; bioactive compounds; nanocomposite; functional composite; composite film and coatings
(This special issue belongs to the Section Materials Science)
Potential Prevention and Treatment of Neurodegenerative Disorders submission deadline 30 Jun 2025 | 3 articles | Viewed by 4710 | Submission Open
Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention
(This special issue belongs to the Section Molecular Neurobiology)
Editorial Board Members’ Collection Series: “Bacterial Enzymes as Targets” submission deadline 30 Jun 2025 | 4 articles | Viewed by 4477 | Submission Open
Keywords: enzymes; cell wall biosynthesis; DNA replication; metabolic pathway; vital bacterial function; enzyme inhibition; antibacterial agents; antibiotic resistance
(This special issue belongs to the Section Biochemistry)
Genetic Engineering of Plants for Stress Tolerance, Second Edition
edited by
submission deadline 30 Jun 2025 | 6 articles | Viewed by 4414 | Submission Open
Keywords: CRISPR-Cas system; RNA interference; abiotic and biotic stresses; transcriptional regulation; post-transcriptional regulation; post-translational modification; genetic evolution; biotechnology; molecular mechanisms; regulatory circuits
(This special issue belongs to the Section Molecular Plant Sciences)
Protein Aggregation and Proteinopathies
edited by Hongyu Hu
submission deadline 30 Jun 2025 | 2 articles | Viewed by 3859 | Submission Open
Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy
(This special issue belongs to the Section Molecular Biology)
Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers submission deadline 30 Jun 2025 | 3 articles | Viewed by 3589 | Submission Open
Keywords: chronic kidney disease (CKD); end-stage renal disease; CKD biomarkers; CKD progression; metabolomics; molecular pathways; biomolecules; CKD anemia; cardiovascular disease risk; CKD-related disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metal Oxide Nanomaterial Properties: Molecular Electrochemistry and Biomedical Applications submission deadline 30 Jun 2025 | 2 articles | Viewed by 2868 | Submission Open
Keywords: inorganic binding biomolecules; nanostructured materials; metal oxide nanoparticles; metal oxide– polymer nanocomposites; active surface sites
(This special issue belongs to the Section Materials Science)
Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 2778 | Submission Open
Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic
(This special issue belongs to the Section Biochemistry)
Fabrication and Application of Photocatalytically Active Materials submission deadline 30 Jun 2025 | 2 articles | Viewed by 2750 | Submission Open
Keywords: semiconductor oxides; photocatalysis; materials science; nanotechnology; activity; catalyst preparation; nanomaterials; environmental applications
(This special issue belongs to the Section Materials Science)
Synthesis and Applications of Photoactive Molecules and Photovoltaic Materials submission deadline 30 Jun 2025 | 1 articles | Viewed by 2625 | Submission Open
Keywords: photochemistry; chromophores; light-activated systems; donor– acceptor structures; covalent and noncovalent chemistry; solar cells
(This special issue belongs to the Section Materials Science)
Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition) submission deadline 30 Jun 2025 | 2 articles | Viewed by 2274 | Submission Open
Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders
(This special issue belongs to the Section Molecular Neurobiology)
Translational Research in Ophthalmic Pathology
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 2093 | Submission Open
Keywords: eye; ophthalmology; immunohistochemistry; molecular biology; pathophysiology; translational science; anatomy; histology; pathology; orbit
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications
edited by Jordi Olloquequi and M. Emília Juan
submission deadline 30 Jun 2025 | 2 articles | Viewed by 1984 | Submission Open
Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling
(This special issue belongs to the Section Molecular Neurobiology)
Nanocrystals, Nanoclusters, Nanoparticles: Synthesis and Optical Properties submission deadline 30 Jun 2025 | 2 articles | Viewed by 1658 | Submission Open
Keywords: nanocrystals; nanoclusters; nanoparticles; synthesis; optical properties
(This special issue belongs to the Section Molecular Nanoscience)
From Nature to Medicine: Exploring Natural Products for New Therapies
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 1444 | Submission Open
Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate
(This special issue belongs to the Section Molecular Pharmacology)
Plant and Environmental Interactions (Abiotic Stress)
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 1369 | Submission Open
Keywords: stress response; signal transduction; metabolism and secondary metabolism; material/vesicle transportation; rhizospheric microorganism; interactions between plants and microorganisms
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Imaging for Cancer Theranostics
edited by and Kai Bao
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1363 | Submission Open
Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oxidative Stress and Autophagy in Cancer Cells
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1356 | Submission Open
Keywords: oxidative stress; autophagy; apoptosis; cancer cells; cancer cell signaling pathways
(This special issue belongs to the Section Molecular Biology)
Molecular Research of Dystonia and Parkinson’s Disease
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 1171 | Submission Open
Keywords: dystonia; Parkinson’ s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomarker Discovery and Validation for Precision Oncology
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 1074 | Submission Open
Keywords: biomarker discovery; biomarker validation; precision oncology; cancer screening; cancer diagnostics; liquid biopsy; multi-omics integration; targeted therapies; immunotherapy biomarkers; translational cancer research
(This special issue belongs to the Section Molecular Oncology)
New Research Insights in Cystic Fibrosis and CFTR-Related Diseases
edited by Judith A. Coppinger
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1070 | Submission Open
Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Algae Molecular Biology and Biotechnology submission deadline 30 Jun 2025 | Viewed by 1016 | Submission Open
Keywords: molecular techniques; microscopy; microspectrophotometry; molecular biology and phylogenetics; processing and pattern recognition in alga images; molecular processes in photoreception; nutraceuticals and functional food production; toxicity; bioremediation; industrial exploitation; health care importance; environmental sustainability
(This special issue belongs to the Section Molecular Plant Sciences)
p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell
edited by Przemyslaw Bozko
submission deadline 30 Jun 2025 | 1 articles | Viewed by 982 | Submission Open
Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Advances in Inborn Errors of Immunity
edited by Aleksandra Szczawińska-Popłonyk
submission deadline 30 Jun 2025 | 1 articles | Viewed by 907 | Submission Open
Keywords: inborn errors of immunity; immune dysregulation; autoimmunity; autoinflammation; organ-specific immunopathology; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
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