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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Nanoparticles in Molecular Biology: Second Edition

edited by

Maciej Monedeiro-Milanowski

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2623 | Submission Open

Keywords: nanoparticles; nanomedicine; biomolecules; nanoparticle– cell interactions; organic– inorganic hybrid; cytotoxic potential

(This special issue belongs to the Section Molecular Nanoscience)

Biological Hallmarks and Therapeutic Strategies in Cancer

edited by Ramesh Kumar

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2610 | Submission Open

Keywords: hallmarks of cancer; cancer progression; chemotherapy; tumorigenesis; oncogenic signaling

(This special issue belongs to the Section Molecular Oncology)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2580 | Submission Open

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

Peptides and Peptidomimetics for Targeting Protein-Protein Interactions

edited by

Giacomo Rossino

and

Pasquale Linciano

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2533 | Submission Open

Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC

(This special issue belongs to the Section Biochemistry)

Advanced Research on Cholangiocarcinoma: From Bench to Bedside

edited by

Masaru Katoh

, Simona Tavolari and

Giovanni Brandi

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2480 | Submission Open

Keywords: risk factors; next-generation sequencing; actionable targets; FGFR2; BAP1; IDH1; tissular/circulating biomarkers; cancer resistance; immune microenvironment; in vitro and in vivo models; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Colorectal Cancer: From Pathophysiology to Novel Therapies

edited by

Fabio Gelsomino

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2478 | Submission Open

Keywords: colorectal cancer; immunotherapy; targeted therapy; biomarkers; multidisciplinary management; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2461 | Submission Open

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

New Cellular and Molecular Insights into Glaucoma

edited by

Meritxell López-Gallardo

and

José A. Fernández-Albarral

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2455 | Submission Open

Keywords: neuroinflammation; microglia; macroglia; retinal ganglion cells; therapeutical approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synapse Dynamics: From Molecular Mechanisms to Functional Plasticity

edited by

Maria Bykhovskaia

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2408 | Submission Open

Keywords: synaptic plasticiy; neuronal transmitters; molecular dynamics; neuronal networks; dendritic spines; synapse formation; synaptic vesicles; active zones; axonal transport

(This special issue belongs to the Section Molecular Neurobiology)

Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition

edited by

François Chevalier

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2403 | Submission Open

Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Design and Therapeutic Applications of Peptide-Based Drugs

edited by

Shayon Bhattacharya

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2391 | Submission Open

Keywords: peptide drug design; in silico drug discovery; peptide– protein interactions; therapeutic peptides

(This special issue belongs to the Section Molecular Biology)

New Advances in Germ Cell Research

edited by

Sheng-Hsiang Li

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2367 | Submission Open

Keywords: spermatogenesis; sperm capacitation; oogenesis; oocyte maturation; cumulus cells; fertilization; gene expression; biomarkers; exosomes; infertility

(This special issue belongs to the Section Molecular Biology)

The Role of microRNA in Human Diseases: 3rd Edition

edited by

Andrey Turchinovich

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2330 | Submission Open

Keywords: microRNA (miRNA); non-coding RNAs; human diseases; cancer; fatty liver; cardiovascular diseases; neurological diseases; viral infection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism in Multiple Sclerosis and Related Disorders: 3rd Edition

edited by

Hans-Peter Hartung

and Kazuo Fujihara

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2310 | Submission Open

Keywords: neurodegeneration; multiple sclerosis; NMOSD; MOGAD; disease-modifying treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Whole-Cell System and Synthetic Biology, 2nd Edition

edited by

Jingjing Tian

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2299 | Submission Open

Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis and Application of Chiral Ligands and Heterocycles in Pharmacological Studies

edited by

István Szatmári

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2294 | Submission Open

Keywords: nonracemic amino acids; enantioselective synthesis; chiral catalysis; enantiopure bioconjugates; electron-rich hydroxyquinoline; indole; β -carboline; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Mechanisms and Implications of Traumatic Brain Injury and Neuroinflammation

edited by

Kwang Choi

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2252 | Submission Open

Keywords: traumatic brain injury; head trauma; neuroinflammation; secondary injury; microglia

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Omics in Cancer Diagnosis and Treatment

edited by Xiaohu Tang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2217 | Submission Open

Keywords: cancer; heterogeneity; omics; biomarker; therapeutic targets; drug resistance; molecular profile; algorithm

(This special issue belongs to the Section Molecular Oncology)

Advances in Fruit Tree Physiology, Breeding and Genetic Research

edited by Jiangping Mao

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2202 | Submission Open

Keywords: fruit tree; genetic breeding; fruit tree physiology; gene functional identification

(This special issue belongs to the Section Molecular Plant Sciences)

Anticancer, Antioxidant, and Anti-Inflammatory Properties of Natural Products

edited by

Rita Carneiro Alves

, Nelson Andrade and Cláudia Silva

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2200 | Submission Open

Keywords: bioactive compounds; natural extracts; health promotion/disease prevention; oxidative stress modulation; inflammatory pathway regulation; anticancer and antitumoral effects; cellular mechanisms; in vitro and in vivo bioactivity studies

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Research in Immunotoxicity and Oxidative Stress

edited by

Soo-Jin Choi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2198 | Submission Open

Keywords: toxicity; macrophage activation; pro-inflammation; anti-inflammation; oxidative stress; foods; food additives; nanomaterials; toxicants; natural compounds

(This special issue belongs to the Section Molecular Toxicology)

Breakthroughs in Cardiac Tissue Remodeling: From Mechanisms to Therapeutics

edited by

Antonio Lax

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2179 | Submission Open

Keywords: myocardial infarction; heart failure; adverse remodeling; cardiac fibrosis; cardiomyopathy; cardiotoxicity; ventricular remodeling; cardiac dysfunction; biomarkers; cardiac regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Precision Medicine During Surgery and Postoperative Care

edited by Lukas Andereggen and Markus M. Luedi

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2147 | Submission Open

Keywords: genomics & pharmacogenomics; molecular mechanisms of anesthesia; perioperative biomarkers; perioperative care; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sarcomas: From Molecular Insights to Personalized Therapies

edited by

Hye Jin You

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2128 | Submission Open

Keywords: soft tissue sarcoma; biomarkers; molecular mechanisms; experimental models; clinical factors associated with sarcoma development

(This special issue belongs to the Section Molecular Oncology)

Research on Intracellular Signal Transduction Systems

edited by

Takaya Satoh

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2120 | Submission Open

Keywords: signal transduction; receptor; G protein; kinase; second messenger; gene expression; cytoskeleton; human disease

(This special issue belongs to the Section Molecular Biology)

Endothelial-to-Mesenchymal Transition: A Key Driver of Tumor Progression and Therapeutic Resistance

edited by

Gabriella Doronzo

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2088 | Submission Open

Keywords: Endothelial-to-Mesenchymal Transition; wound healing and fibrosis; tumor progression; abnormal blood vessel formation; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Bile Acids and Bile Acid Modifications in Health and Disease

edited by

Francisco J. Osuna-Prieto

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2084 | Submission Open

Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders

(This special issue belongs to the Section Molecular Microbiology)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2068 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease

edited by Sophia Lavrentiadou

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2059 | Submission Open

Keywords: Alzheimer’ s disease; neuroinflammation; anti-inflammatory strategies; cell models

(This special issue belongs to the Section Molecular Neurobiology)

Interactions between Plants and Nematodes

edited by Qian Liu

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2039 | Submission Open

Keywords: plant nematodes; hosts; interaction; effectors; giant cells; syncytia

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Animal Reproduction

edited by

Zhongliang Jiang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2010 | Submission Open

Keywords: spermatogenesis; follicular atresia; oocyte maturation; granulosa cells; hormone regulation; autophagy; apoptosis; miRNA; signaling regulation

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets for Endometriosis

edited by Katharina Proestling and

Iveta Yotova

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1973 | Submission Open

Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Developments in Molecular Genetic Breeding of Forest Trees

edited by

Su Chen

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1947 | Submission Open

Keywords: tree genetics; tree breeding; molecular breeding; genetic improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Biomarkers in Precision Medicine

edited by

Zhidong Zhou

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1908 | Submission Open

Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

The Role of Amyloid in Neurological Diseases

edited by Silvia Purro

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1886 | Submission Open

Keywords: amyloid-beta (Aβ ); tau protein; TDP43; synuclein; huntingtin; prion-like mechanisms; amyloid structures; genetic factors; cell-to-cell transmission; pathogenesis mechanisms; protein aggregation; Biomarkers; CNS amyloid clearance and degradation

(This special issue belongs to the Section Molecular Neurobiology)

Role of Extracellular Vesicles in Diseases

edited by

Gorjana Rackov

and

Aoife Ward Gahlawat

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1880 | Submission Open

Keywords: extracellular vesicles (EVs); biomarkers; disease pathophysiology; miRNAs; intercellular communication; therapeutic targets; mitochondrial transfer; cancer; neurodegenerative disorders; precision medicine

(This special issue belongs to the Section Biochemistry)

Thermodynamic and Spectral Studies of Complexes

edited by Michał Zabiszak

submission deadline 20 Nov 2025 | 3 articles | Viewed by 1876 | Submission Open

Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry

edited by

Yang Gao

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1845 | Submission Open

Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry

(This special issue belongs to the Section Materials Science)

Molecular Insights into Placental Pathology

edited by

Mary Wallingford

and Ana Correia-Branco

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1806 | Submission Open

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glial Cells in Neurodegenerative Disorders

edited by Daniel Souza Monteiro de Araujo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1800 | Submission Open

Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders

(This special issue belongs to the Section Molecular Neurobiology)

Basic, Translational and Clinical Research on Dementia—Second Edition

edited by

Giacinto Bagetta

Damiana Scuteri

and Daniele Bano

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1779 | Submission Open

Keywords: dementia; Alzheimer’ s disease; amyloid-beta; tau protein

(This special issue belongs to the Section Molecular Neurobiology)

Biomaterials for Tissue Regeneration: Current Progress and Future Directions

edited by

Ana Caruntu

and Horia Barbu

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1774 | Submission Open

Keywords: biomaterials; biocompatibility; tissue engineering; tissue defect; rehabilitation; scaffolds; regenerative medicine; angiogenesis; stem cells; antimicrobial

(This special issue belongs to the Section Materials Science)

Regulatory Network of Bone Metabolism

edited by

Kazunori Hamamura

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1747 | Submission Open

Keywords: osteoblasts; osteoclasts; osteocytes; mesenchymal stem cells; bone metabolism; bone formation; bone resorption

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Molecular Biology on Mycobacteria: 2nd Edition

edited by

Rita Macedo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1703 | Submission Open

Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Mechanisms of Comorbidities in Rheumatic Diseases

edited by

Marino Paroli

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1673 | Submission Open

Keywords: inflammatory and autoimmune rheumatic diseases; comorbidities; autoimmunity; T-cell response

(This special issue belongs to the Section Molecular Immunology)

Sulfur-Containing Compounds: Synthesis, Characterization and Antimicrobial or Anticancer Activity

edited by

Paola Bonaccorsi

Chiara Maria Antonietta Gangemi

and

Anna Barattucci

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1588 | Submission Open

Keywords: sulfurated compounds; sulfoxides; disulfides; sulfides; thiosulfinates; xanthates; antibacterial; antivirus; anticancer; antimicrobial

(This special issue belongs to the Section Biochemistry)

Lipopolysaccharide in the Health and Disease

edited by

Gen-Ichiro Soma

and Hiroyuki Inagawa

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1569 | Submission Open

Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer

(This special issue belongs to the Section Biochemistry)

Challenges of Immune Checkpoint Inhibitor Therapy

edited by

Tibor Bakacs

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1537 | Submission Open

Keywords: immune checkpoint inhibitor; ICI; safety of ICI drugs; irAE of ICI drugs; ultra-low-dose ICI; cost saving with ICI drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections

edited by

Luciana Barros de Arruda

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1530 | Submission Open

Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Crosstalk Between Bone and Inflammation

edited by Jessica Cottrell

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1522 | Submission Open

Keywords: bone; inflammation; immunology; bone metabolism; inflammatory disease

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 801-850 on page 17 of 68.

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