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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nanomedicine for Cancer Diagnosis and Therapy

edited by

Suresh Thangudu

submission deadline 31 Jul 2026 | Viewed by 283 | Submission Open

Keywords: nanomaterials; multifunctional properties; anticancer nanotechnology; image guided nano platforms; in vivo evaluation; delivery approaches; immune-nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Lysosomal Storage Disorders: Molecular Pathogenesis and Next-Generation Therapeutics

edited by

Olga Amaral

and

Ari Zimran

submission deadline 31 Jul 2026 | Viewed by 280 | Submission Open

Keywords: lysosomal storage disorders; cellular mechanisms; multi-omics biomarkers; gene therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Biophysical Studies on Lipid Membranes

edited by Wallance Moreira Pazin

submission deadline 31 Jul 2026 | Viewed by 280 | Submission Open

Keywords: membrane biophysics; lipid organization; lipid– protein interactions; molecular dynamics simulations; membrane mechanics; nanoscale transport; model membrane systems; biomolecular interactions; membrane structure and dynamics; molecular-level characterization

(This special issue belongs to the Section Molecular Biophysics)

Molecular, Cellular Mechanisms and Pathophysiology of Glioblastoma

edited by Agnieszka Rusak

submission deadline 31 Jul 2026 | Viewed by 278 | Submission Open

Keywords: glioblastoma; targeted terapy; molecular patchway; drug carriers; biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Host DNA Damage Responses in Virus Propagation and Human Disease

edited by Nimrat Chatterjee

submission deadline 31 Jul 2026 | Viewed by 273 | Submission Open

Keywords: DNA repair; DNA viruses; RNA viruses; translesion synthesis; cancer

(This special issue belongs to the Section Molecular Microbiology)

Advances in Specialized Metabolites from Medicinal Plants

edited by Hong Wang

submission deadline 31 Jul 2026 | 1 articles | Viewed by 270 | Submission Open

Keywords: medicinal plants; specialized metabolites; medicinal– edible traditional Chinese medicines; natural products; multidimensional LC– MS; metabolomics; proteomics; biosynthesis; bioactive compound screening; molecular mechanisms; multi-omics integration

(This special issue belongs to the Section Molecular Plant Sciences)

Microfluidic Organ-on-a-Chip: Bridging Drug Discovery to Precision Medicine

edited by Yongjian Ai and Mengqi He

submission deadline 31 Jul 2026 | Viewed by 265 | Submission Open

Keywords: absorption; distribution; metabolism; excretion; toxicity; host– pathogen; host-immune; pharmacokinetic; pharmacodynamic; absorption; metabolism; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Mathematical Calculation and Modeling in Biology

edited by Nan Sheng

submission deadline 31 Jul 2026 | Viewed by 262 | Submission Open

Keywords: mathematical modeling; computational biology; machine/deep learning; molecular biology; molecular interactions; gene; protein; small molecule; computational drug design; multi-omics

(This special issue belongs to the Section Molecular Informatics)

Targeted Cancer Therapeutics: Molecular Pathways and Precision Strategies

edited by

Kausik Bishayee

submission deadline 31 Jul 2026 | Viewed by 261 | Submission Open

Keywords: targeted cancer therapy; small molecules; combination therapy; inhibitors; cancer cell death and proliferation

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Oral and Periodontal Health

edited by

Giuseppina Malcangi

, Roxana Ioana Bordea and Grazia Marinelli

submission deadline 31 Jul 2026 | Viewed by 259 | Submission Open

Keywords: dental disease; dental materials; orthodontic diseases; growth factor; regenerative tissue; peritonitis; regulatory T cells; systemic disease; systemic inflammation; scaling and root planning

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Developments in Bioactive and Functional Nanomaterials

edited by Mónica Rosalía Jaime-Fonseca, José Abraham Balderas López and Miguel Angel Aguilar Méndez

submission deadline 31 Jul 2026 | Viewed by 256 | Submission Open

Keywords: bioactives; nanostructured materials; nanoparticles; nanofibers; nanomedicine drug delivery; biosensors; smart food packaging; functional foods; sustainable agriculture

(This special issue belongs to the Section Molecular Nanoscience)

New Mechanisms and Therapeutics in Neurological Diseases—5th Edition

edited by

Barbara Mroczko

submission deadline 31 Jul 2026 | Viewed by 252 | Submission Open

Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins

(This special issue belongs to the Section Molecular Neurobiology)

Nutrition for Muscle Health and Metabolism

edited by

Hira Shakoor

submission deadline 31 Jul 2026 | Viewed by 251 | Submission Open

Keywords: nutrition; skeletal muscle; muscle metabolism; mitochondrial function; insulin sensitivity; myokines; metabolic health; metabolic disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Epitranscriptomics: RNA Modifications and Function

edited by Caroline Vissers

submission deadline 31 Jul 2026 | Viewed by 244 | Submission Open

Keywords: epitranscriptome; methylation; mRNA; rRNA; RNA modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research Progress of Forensic Genetics

edited by

Mariano Guardado-Estrada

submission deadline 31 Jul 2026 | Viewed by 241 | Submission Open

Keywords: forensic genetics; genomics; phenotyping; DNA sequencing; pedigree; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Interplay of Nanoparticles with Plant Physiology and Molecular Biology: Effects, Mechanisms and Agricultural Applications

edited by

Zaid Ulhassan

submission deadline 31 Jul 2026 | Viewed by 240 | Submission Open

Keywords: plant nano biology; abiotic stress tolerance; physiological and molecular mechanisms; nanotoxicology; detoxification strategies

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Glomerular Diseases, 2nd Edition

edited by

Gian Marco Ghiggeri

submission deadline 31 Jul 2026 | Viewed by 239 | Submission Open

Keywords: glomerulonephritis; proteinuria; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on the Antioxidant, Anti-Inflammatory, and Antibacterial Activities of Natural Products

edited by

Carmen Lizette Del Toro Sánchez

and

Ariadna Thalia Bernal-Mercado

submission deadline 31 Jul 2026 | Viewed by 238 | Submission Open

Keywords: natural bioactive compounds; antioxidant mechanisms; anti-inflammatory pathways; antibacterial activity; agro-industrial byproducts; molecular docking; structure– activity relationship (SAR); omics technologies; drug delivery systems; nanobiotechnology; bioavailability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Role of Ion Channels in Heart Health and Diseases

edited by Ernesto Alejandro Aiello

submission deadline 31 Jul 2026 | Viewed by 237 | Submission Open

Keywords: ion channels; heart; channelopathies; hypertrophy; heart failure; ischemia; hypertension; inflammation

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Steroid Hormones and Sex Hormones

edited by

Eloísa Da Silveira Loss

submission deadline 31 Jul 2026 | Viewed by 237 | Submission Open

Keywords: membrane androgen receptors; G protein-coupled estrogen receptor; membrane progesterone receptors; membrane glucocorticoid receptor; genomic steroid receptors; rapid immune effects; non-genomic signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research of Host-Pathogen Interactions

edited by

Alina Maria Holban

and

Carmen Curutiu

submission deadline 31 Jul 2026 | Viewed by 231 | Submission Open

Keywords: host– pathogen interactions; host immunity during infection; new targets for resistant pathogens; molecular communication during infection; model systems in host– pathogen studies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Dementia and Application of Biomarkers

edited by

Teresa Juárez-Cedillo

submission deadline 31 Jul 2026 | Viewed by 230 | Submission Open

Keywords: Alzheimer's; diagnosis; biological marker; protein; therapeutic target

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism of Xenobiotics on Respiratory Disorders

edited by

Miguel Santibáñez-Andrade

submission deadline 31 Jul 2026 | Viewed by 228 | Submission Open

Keywords: xenobiotics; polycyclic aromatic hydrocarbons-PHAs; volatile organic compounds-VOCs; metals; respiratory disorders; asthma; chronic obstructive pulmonary disease (COPD); lung cancer; environmental pollutants; DNA methylation; non-coding RNA deregulation; oxidative damage

(This special issue belongs to the Section Molecular Biology)

Latest Research in Bioactive Compounds

edited by

Seiji Shioda

submission deadline 31 Jul 2026 | Viewed by 224 | Submission Open

Keywords: peptides; nervous system; feeding regulation; glucose; lipid metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Molecular Research on Snake Venoms

edited by

Isadora Sousa De Oliveira

and

Eliane Candiani Arantes

submission deadline 31 Jul 2026 | Viewed by 224 | Submission Open

Keywords: snake venoms; venomics; toxin diversity; toxin evolution; structure– function relationships; bioactive peptides; antivenom development; recombinant toxins; molecular mechanisms of toxicity

(This special issue belongs to the Section Molecular Biology)

Polycystic Ovary Syndrome: Targeted Therapeutics and Future Perspectives

edited by Noha Shawky and

Manar A. Eissa

submission deadline 31 Jul 2026 | Viewed by 224 | Submission Open

Keywords: PCOS; maternal-offspring; developmental origins of health and disease; aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Genomics and Immunotherapy: Mechanisms, Biomarkers, and Clinical Translation

edited by

Apostolos Zaravinos

submission deadline 31 Jul 2026 | Viewed by 222 | Submission Open

Keywords: cancer genomics; cancer immunotherapy; tumor immune microenvironment; immunogenomics biomarkers; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Genetic-Driven Precision Oncology in Prostate Cancer

edited by

Pierre Tennstedt

submission deadline 31 Jul 2026 | Viewed by 222 | Submission Open

Keywords: prostate cancer; genetic; biomarker; liquid biopsy; urine; blood; tissue; treatment strategies; diagnosis; progression; metastasis; survival; hormone-sensitive; hormone-resistant; androgen deprivation therapy

(This special issue belongs to the Section Molecular Oncology)

Viral Infection: Molecular Mechanisms and Vaccine Approaches

edited by

Ismaïl Moukadiri

submission deadline 31 Jul 2026 | Viewed by 220 | Submission Open

Keywords: viral infection; molecular virology; molecular mechanisms; antigen engineering; next-generation vaccine design

(This special issue belongs to the Section Molecular Immunology)

Proteoglycans and Glycosaminoglycans in Cancer Biology and Therapy

edited by Masao Nakamura

submission deadline 31 Jul 2026 | Viewed by 218 | Submission Open

Keywords: proteoglycans; glycosaminoglycans; tumor microenvironment; chondroitin sulfate; heparan sulfate; sulfation patterns; extracellular matrix remodeling; metastasis and invasion; angiogenesis; immune evasion; antibody therapeutics and ADCs; drug resistance mechanisms

(This special issue belongs to the Section Molecular Oncology)

Coordination Architectures for Next-Generation Chemical Sensors: Metal Complexes, Coordination Polymers and MOFs

edited by

Tamara Basova

and

Darya Klyamer

submission deadline 31 Jul 2026 | Viewed by 216 | Submission Open

Keywords: metal complexes; coordination polymers; MOFs

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Calcium Signaling in Human Health and Diseases, 4th Edition

edited by

Francesco Moccia

submission deadline 31 Jul 2026 | Viewed by 215 | Submission Open

Keywords: Ca2+ signalling; intracellular organelles; plasma membrane; inositol-1; 4; 5-receptors; ryanodine receptors; ionotropic receptors; metabotropic receptors; TRP channels; two-pore channels; STIM and Orai

(This special issue belongs to the Section Biochemistry)

Microbes in Obstetrics: Current Importance of Ascending Bacterial Infection (ABI)

edited by Alfredo Ovalle and Enrique Oyarzun

submission deadline 31 Jul 2026 | Viewed by 212 | Submission Open

Keywords: ascending bacterial infection (ABI); vaginal dysbiosis; spontaneous preterm birth (sPTB); group B streptococcus (GBS); fetal inflammatory response syndrome (FIRS); microbiomics; maternal immunology; cervical insufficiency

(This special issue belongs to the Section Molecular Microbiology)

Computational Models in Oncology: From Tumor Initiation to Progression to Treatment

edited by

Vladimir Simic

submission deadline 31 Jul 2026 | Viewed by 209 | Submission Open

Keywords: computational models; tumor growth; computational oncology; multiscale modeling; cancer progression; treatment response modeling; mathematical modeling

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Plant–Microbial Interaction

edited by

Diby Paul

submission deadline 31 Jul 2026 | Viewed by 207 | Submission Open

Keywords: plant microbe intractions; molecular mechanisms; microbiome dynamics; multi-omics approach; stress responses; metagenomics; rhizosphere signalling

(This special issue belongs to the Section Molecular Microbiology)

Exploring Molecular Mechanisms of Lens Development and Growth

edited by

Michael L. Robinson

submission deadline 31 Jul 2026 | Viewed by 206 | Submission Open

Keywords: lens development; lens fiber cell differentiation; organelle degradation; transcriptional regulation; signal transduction; lens regeneration; chromatin remodeling; ocular development

(This special issue belongs to the Section Molecular Biology)

Advances in Cardiovascular Disease: Pathophysiology, Diagnosis, and Therapy

edited by Masaru Tanaka

submission deadline 31 Jul 2026 | Viewed by 206 | Submission Open

Keywords: cardiovascular disease; endothelial dysfunction; vascular remodeling; inflammation; immunothrombosis; biomarkers; extracellular vesicles; mitochondrial dysfunction; cellular senescence; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Spinal Cord Injury: A Comprehensive Approach to Pathophysiology, Treatment, and Recovery

edited by Raúl Silva Garcia and Elisa García-Vences

submission deadline 31 Jul 2026 | Viewed by 205 | Submission Open

Keywords: spinal cord injury; neuroprotection; inflammation; therapy; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral-Host Interplay: Molecular Mechanisms of Immunity and Pathogenesis

edited by

Jarosław Widelski

submission deadline 31 Jul 2026 | Viewed by 204 | Submission Open

Keywords: virus– host interaction; innate immunity; viral immune evasion; pathogenesis; pattern recognition receptors (PRRs); adaptive immunity; antiviral defense

(This special issue belongs to the Section Molecular Immunology)

Mitochondrial Bioenergetics and Signaling in Diseases

edited by

Carlos Palmeira

and

Anabela P. Rolo

submission deadline 31 Jul 2026 | Viewed by 201 | Submission Open

Keywords: mitochondria; bioenergetics; oxidative phosphorylation; mitochondrial signaling; metabolism; reactive oxygen species (ROS); mitochondrial dynamics; mitophagy; calcium signaling; mitochondrial DNA; redox homeostasis; cell death; inflammation; neurodegeneration; cancer metabolism; cardiometabolic diseases; aging; therapeutic targeting

(This special issue belongs to the Section Biochemistry)

Epigenetic and Molecular Control of Plant Hormones in Development and Abiotic Adaptation

edited by

Leonardo Bruno

and

Emanuela Talarico

submission deadline 31 Jul 2026 | Viewed by 199 | Submission Open

Keywords: plant hormones; phytohormone signaling; epigenetic regulation; chromatin remodeling; abiotic stress; plant development; hormone crosstalk; stress adaptation; epigenetic memory

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Progress in Fabrication, Properties, and Applications of Biomaterials for Tissue Engineering

edited by

Paulina Sobierajska

and

Rafał Jakub Wiglusz

submission deadline 31 Jul 2026 | Viewed by 198 | Submission Open

Keywords: biomedical applications; tissue engineering; biomaterials; nanomaterials; scaffolds; hydrogels; cell– material interaction; 3D printing; bioreactors

(This special issue belongs to the Section Materials Science)

Deciphering the Molecular Mechanisms and Etiology of Thrombosis

edited by Omri Snir

submission deadline 31 Jul 2026 | Viewed by 198 | Submission Open

Keywords: thrombogenesis; molecular mechanisms; etiology; thrombo-inflammation; therapeutic targets; endothelial dysfunction; extracellular vesicles; coagulation; fibrinolysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Investigations in Neurodevelopmental Disorders: 2nd Edition

edited by Giorgio Medici

submission deadline 31 Jul 2026 | Viewed by 198 | Submission Open

Keywords: neurodevelopmental disorders; brain; neurons; synapses; molecular research; regulatory networks; molecular pathways; biomarkers; therapies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Cellular Functions of Tubulin in Neuronal Health and Disease

edited by

Antonella Sferra

submission deadline 31 Jul 2026 | Viewed by 195 | Submission Open

Keywords: tubulin; microtubules; neurodegeneration; neuron; brain; neurodevelopment; motor proteins

(This special issue belongs to the Section Molecular Biology)

Beyond Solid-State Drugs: Liquid-State Pharmaceutical Re-Engineering—from Molecular Design to Delivery Performance

edited by

O. Andreea Cojocaru

submission deadline 31 Jul 2026 | Viewed by 195 | Submission Open

Keywords: liquid-state pharmaceuticals; pharmaceutical re-engineering; active pharmaceutical ingredient ionic liquids (API-ILs); deep eutectic and ionic systems; solid-to-liquid drug transformation; physicochemical property modulation; structure– property– performance relationships; non-oral drug delivery; molecular design of pharmaceutical materials; drug solubility enhancement; permeability and drug delivery; solid-to-liquid transformation; transdermal delivery; pharmaceutical material design; ionic and hydrogen-bonded pharmaceutical systems

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Biomarkers of Renal Injury: Bridging the Gap Between Micro-Environment Damage and Clinical Diagnosis

edited by Alexandre Braga Libório

submission deadline 31 Jul 2026 | Viewed by 194 | Submission Open

Keywords: renal injury; molecular biomarkers; AKI-CKD transition; regulated cell death; precision nephrology; renal microenvironment; epigenetics; tubulointerstitial fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Natural Products to Synthetic Small-Molecule Antioxidants: Mechanistic and Kinetic Foundations for Drug Discovery

edited by Cvijeta Jakobušić Brala

submission deadline 31 Jul 2026 | Viewed by 190 | Submission Open

Keywords: oxidative stress; antioxidant mechanisms; reaction kinetics; natural products; small-molecule antioxidants; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms Regulating Oxidative and Stress Responses in Pseudomonas aeruginosa: Implications for Adaptation and Virulence

edited by Magdalena Pezzoni

submission deadline 31 Jul 2026 | Viewed by 190 | Submission Open

Keywords: Pseudomonas aeruginosa; oxidative stress; stress response regulation; redox homeostasis; transcriptional regulation; small RNAs; virulence and persistence; antibiotic resistance

(This special issue belongs to the Section Molecular Microbiology)

Extracellular Vesicles as Drivers of Cancer Therapy Resistance: Mechanistic Insights and Emerging Therapeutic Strategies

edited by Abraham Pedroza-Torres

submission deadline 31 Jul 2026 | Viewed by 190 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer resistance; tumor microenvironment; biomolecule transfer

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 801-850 on page 17 of 65.

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