Characterization of Immune and Inflammatory Tumor Microenvironment on Canine, Feline and Human Species
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 30
Special Issue Editor
2. UNIPRO—Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS-CESPU), Gandra, Portugal
3. Pathology Department, INNO Serviços Especializados em Veterinária, Braga, Portugal
Interests: oral medicine; oral cancer; carcinogenesis; premalignant lesions; biomarkers; laser
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The increase in the average life expectancy of humans and pets is probably contributing to a higher incidence of neoplasms, with oncological diseases currently being one of the main causes of death. In addition, the oncological study in companion animals serves as a comparative model for cancer in humans in a “One Health” approach, since our animals share our environment and are exposed to multiple risk factors regarded as carcinogenic.
The tumor microenvironment, particularly its immune cell composition—including tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), key immune checkpoints (PD-1, PD-L1, CTLA-4), regulatory T cells (Tregs), and cytokine profiles—critically influences carcinogenesis, progression, and immune evasion.
From this point of view, the immunological study of tumors and the search for molecules with prognostic value can open doors for a deep understanding of cancer progression and survival with specialized characterization of each tumor of a human or companion animal patient in search of a better prognosis.
This Special Issue is interested in all the aspects of the immune and inflammatory tumor microenvironment in human and veterinary patients that might contribute to an increase in the knowledge on the profile and role of inflammation in cancer.
This Special Issue is supervised by Dr. Luís Monteiro and assisted by our Assistant Guest Editor Dr. Maria Leonor Delgado (Department of Veterinary Medicine, University Institute of Health Sciences (IUCS-CESPU), 4585-116 Gandra, Portugal).
Dr. Luís Monteiro
Guest Editor
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Keywords
- inflammation
- tumor microenvironment
- cancer biomarkers
- comparative pathology
- cancer epidemiology
- cancer risk factors
- molecular diagnostics
- proteomics
- treatment response
- targeted therapy
- immunotherapy
- translation cancer research
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