New Molecular Research on High-Fat Diet on Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 20 July 2026 | Viewed by 747
Editor
Interests: obesity; insulin resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As the Editor of this Special Issue, I am pleased to invite researchers from around the world to submit their research to "New Molecular Research on High-Fat Diet on Human Health and Disease". This collection aims to synthesize innovative research elucidating metabolic alterations induced by high-fat diet models, with an emphasis on underlying mechanisms. The primary emphasis of this Special Issue is to consolidate the characterization of high-fat diet-induced models to standardize doses, times, and treatment periods. Obesity induced by a high-fat diet is a versatile model to design models of dietary or drug interventions, both preventive and therapeutic strategies against co-morbidities associated with obesity. A high-fat diet is commonly used to induce obesity, consistently producing metabolic, hormonal, and inflammatory disorders that replicate human obesity. This makes a high-fat diet a highly useful experimental tool for modeling disease progression and elucidating molecular mechanisms directly affecting tissues.
The field has advanced significantly in revealing the effects of fat or sugar intake, exposure duration, sex differences, and environmental variables on metabolic outcomes. We can create reproducible experimental frameworks that enable reliable comparisons across studies and experimental designs by improving and standardizing high-fat diet protocols.
High-fat diet-based models offer a remarkable opportunity to investigate the mechanistic development of obesity, encompassing systemic metabolic dysregulation, chronic inflammation, hormonal imbalance, and organ-specific adaptations. Researchers can use these models to examine tissue-specific responses in the brain, gut, cardiovascular system, liver, skeletal muscle, and adipose tissue in detail, thereby understanding the pathophysiology of obesity-related diseases. This Special Issue also emphasizes the value of high-fat diet models in identifying new treatments against obesity. In the decade of GLP-1 agonists, high-fat diet models remain critical to translational research, particularly for pharmacological interventions. They are powerful tools for identifying new molecular targets, validating biomarkers, and testing new interventions relevant to clinical practice because they are reusable and widely used.
We are pleased to receive original research articles, reviews, methodological papers, and new experimental results that help us better understand how high-fat diets affect human health. We especially encourage contributions that explore new pathways, multi-omics approaches, digital and AI-assisted analyses, and tissue-specific characterizations.
I would love for you to help us make this exciting Special Issue. We can push the boundaries of science, promote reproducibility, and develop new approaches to treat obesity and its global impacts in this prestigious journal.
We look forward to seeing your great submissions!
Prof. Dr. Berta Alejandra Espinosa Escalona
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- obesity
- diet-induced obesity
- antioxidants
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