Molecular Mechanisms of Pesticide Toxicity and Action
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 20 July 2026 | Viewed by 682
Special Issue Editor
Interests: epigenetics; animal reproduction; transcriptomics; next generation sequencing; gene expression and chromatin biology; recombination; RNA genetics; developmental biology; molecular biology
Special Issue Information
Dear Colleagues,
In modern agriculture, a huge array of pesticides is used to control pests, fungi, and undesirable plants. The negative effects of pesticides increase when pesticide actions are combined with other industrial pollutants, such as urban air, perfluoroalkyl and polyfluoroalkyl substances, heavy metals, micotoxins, and plasticizers. The effects of pesticides are also enhanced due to global warming.
While several studies suggest that pesticides could impact many cellular processes, including neuroendocrine and endocrine functions, detoxification systems, the brain–gut microbiota axis, the brain, and reproductive organs, the mechanisms of toxicity at environmental low doses are still uncertain, as many studies have a tendency to use elevated doses. It is still not wholly understood whether the acquired effects could be long-lasting through epigenetic inheritance mechanisms that could impact an individual’s life over a long period after the exposure. We also need to reveal whether ancestral exposure could impact several generations. Additionally, sex-specific differences are still not well described. The discovery of new biomarkers of exposure and effects would be beneficial for human epidemiological studies.
In this Special Issue, manuscripts describing the mechanisms of pesticide toxicity are welcome. This could include the molecular mechanisms of pesticides using model organisms, as well as the human organoid models.
Dr. Fatima Smagulova
Guest Editor
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Keywords
- neonicotinoids
- sex-specific effects
- brain–gut–microbiome
- endocrine organs
- genotoxic effects
- epigenetic effects
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