Molecular Research of Neonicotinoid Toxicity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 76
Special Issue Editor
Interests: epigenetics; animal reproduction; transcriptomics; next generation sequencing; gene expression and chromatin biology; recombination; RNA genetics; developmental biology; molecular biology
Special Issue Information
Dear Colleagues,
Neonicotinoids are the most widely used insecticides; they target nicotinic acetylcholine receptors in insects. Neonicotinoids are water soluble and easily spread through groundwater to many water sources. The excessive use of neonicotinoids has led to their tremendous environmental accumulation in some countries; therefore, humans and wildlife are now at risk of diseases. Neonicotinoids affect many organs, including the nervous system, liver, immune system, and reproductive organs. It is suggested that neonicotinoids also exhibit endocrine-disrupting functions. Moreover, neonicotinoids can induce effects that are transmitted to subsequent generations, suggesting that some alterations induced by neonicotinoids are preserved in gametes. While the toxic effects of neonicotinoids have been well documented, there are still open questions relating to this topic. For example, there is still a gap in the systematic analysis of the brain–gut–microbiome or brain–endocrine organ axes. The sex-specific effects of neonicotinoids are not well presented. Their effects on epigenetic regulation and genotoxic effects are missing for the majority of neonicotinoids.
The purpose of this Special Issue is to provide up-to-date information on the mechanisms of toxicity of neonicotinoids that highlight sex-specific effects in different model organisms; additionally, new studies on the genotoxic and epigenetic effects of neonicotinoids are welcomed.
Dr. Fatima Smagulova
Guest Editor
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Keywords
- neonicotinoids
- sex-specific effects
- brain–gut–microbiome
- endocrine organs
- genotoxic effects
- epigenetic effects
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