Recent Advances in Lipopolysaccharides
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 15
Special Issue Editors
Interests: protein folding; heat shock response; peptidyl prolyl cis/trans isomerases; disulfide bond formation; RpoE sigma factor; two-component systems; envelope stress; transcription factors; lipopolysacchari
Special Issues, Collections and Topics in MDPI journals
Interests: lipopolysaccharide assembly and its modifications: heat shock response; protein folding catalysts; chaperones; proteases; regulatory RNAs; two-component systems; RpoE sigma factor
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cell envelope of Gram-negative bacteria is composed of an asymmetric outer membrane (OM), the periplasm, and an inner membrane. This asymmetry is due to the location of lipopolysaccharide (LPS) in its outer leaflet, with the inner leaflet containing phospholipids. The maintenance of this asymmetry is crucial for bacterial viability; hence, bacteria keep a tight balance between LPSs and phospholipids. The biosynthesis and assembly of LPSs require several essential genes. Being unique to bacteria makes them targets for the discovery of new antibiotics. LPSs are potent activators of the mammalian immune system. Bacteria often alter their LPS composition, due to changes in acylation and modifications of the LPS core and lipid A part, often conferring antibiotic resistance or evading detection by the immune system. Recent studies have unraveled novel essential components in the regulation of a close balance between LPS and phospholipid content, LPS transport to the OM and the role of cardiolipins. In this Special Issue, the diversity of the LPS structure, its modifications, molecular basis of structural alterations, balancing of LPS and phospholipid content, assembly of LPS and detection of LPS by host immune system will be covered.
Prof. Dr. Satish Raina
Dr. Gracjana Klein
Guest Editors
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Keywords
- LPS structural diversity
- lipid A
- amino arabinose and phosphoethanolamine
- TLR4
- antibiotic resistance
- Lpt transport system
- phospholipids and fatty acids
- cell envelope stress
- lipid A acyltransferases
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