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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition
edited by
submission deadline 20 Nov 2026 | 3 articles | Viewed by 9661 | Submission Open
Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies
(This special issue belongs to the Section Molecular Neurobiology)
Glioblastoma: Molecular Pathogenesis and Treatment submission deadline 20 Nov 2026 | 3 articles | Viewed by 8612 | Submission Open
Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies
edited by
submission deadline 20 Nov 2026 | 3 articles | Viewed by 7312 | Submission Open
Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Natural Compounds in Neuroscience
edited by
submission deadline 20 Nov 2026 | 3 articles | Viewed by 7309 | Submission Open
Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Research on Cancer Stem Cells
edited by and Inta Liepniece-Karele
submission deadline 20 Nov 2026 | 4 articles | Viewed by 5916 | Submission Open
Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma
(This special issue belongs to the Section Molecular Oncology)
Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches
edited by Magaly Martinez-Ferrer
submission deadline 20 Nov 2026 | 1 articles | Viewed by 5826 | Submission Open
Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker
(This special issue belongs to the Section Molecular Oncology)
Bioactives from Natural Products submission deadline 20 Nov 2026 | 4 articles | Viewed by 5518 | Submission Open
Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Genomics, Genetics, and the Future of Fruit Improvement
edited by Zoe Hilioti
submission deadline 20 Nov 2026 | 3 articles | Viewed by 4435 | Submission Open
Keywords: fruit traits; genetics; genetic diversity; omics; new breeding techniques; fruit quality; shelf life
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Cancer Stem Cells
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 3581 | Submission Open
Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy
(This special issue belongs to the Section Biochemistry)
Molecular Research on Dyslipidemia submission deadline 20 Nov 2026 | 2 articles | Viewed by 3544 | Submission Open
Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Next-Generation Therapeutic Polymers: From Molecular Design to Dual Antibacterial/Antithrombotic Action
edited by
submission deadline 20 Nov 2026 | 2 articles | Viewed by 2941 | Submission Open
Keywords: antibacterial polymers; antifouling polymers; anticoagulant polymers; heparin-mimicking polymers; heparin-conjugated polymers; phosphorylcholine-based polymers; polymeric nitric oxide donors; polymers, loaded with silver ions, or antibiotics; antibacterial nano- and micro particles; anticoagulant layers
(This special issue belongs to the Section Materials Science)
Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery
edited by
submission deadline 20 Nov 2026 | 2 articles | Viewed by 2575 | Submission Open
Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems
(This special issue belongs to the Section Molecular Biology)
Current Research on Colloidal Emulsions: Preparation and Applications
edited by Alexander Djerdjev
submission deadline 20 Nov 2026 | 2 articles | Viewed by 2488 | Submission Open
Keywords: emulsion formulation and stability; nano-, micro-, and high-internal-phase emulsions; drug delivery; aerogels; pickering emulsions; food emulsions; oil–water interface; surfactants; zeta potential at hydrophobic interfaces; advances in emulsion technology
(This special issue belongs to the Section Materials Science)
Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies
edited by Noah R. Johnson and
submission deadline 20 Nov 2026 | 3 articles | Viewed by 2383 | Submission Open
Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery
(This special issue belongs to the Section Molecular Neurobiology)
Allergic Reactions and Immune Factors submission deadline 20 Nov 2026 | 2 articles | Viewed by 2255 | Submission Open
Keywords: allergic reactions; immunity; immunological factors; hypersensitivity; antibody; cytokine; immune response; etiology; pathogenesis; clinical manifestations; diagnostic; therapy
(This special issue belongs to the Section Molecular Immunology)
Flow Cytometry as a Tool for Diagnostics and Biomarker Research submission deadline 20 Nov 2026 | 1 articles | Viewed by 2204 | Submission Open
Keywords: biomarkers; flow cytometry; spectral cytometry; mass cytometry; translational research; human health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomolecular Condensates and Their Role in Cellular Organization and Disease
edited by Anna Bratek-Skicki
submission deadline 20 Nov 2026 | 1 articles | Viewed by 2170 | Submission Open
Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases
(This special issue belongs to the Section Molecular Biology)
Current Research on Autophagy in Aging and Age Related Diseases
edited by
submission deadline 20 Nov 2026 | 2 articles | Viewed by 2070 | Submission Open
Keywords: autophagy; aging; molecular mechanisms; age related diseases; mitochondria
(This special issue belongs to the Section Biochemistry)
Recent Progress in Synthesis, Properties, and Applications of Polyoxometalates and Their Nanocrystals
edited by and
submission deadline 20 Nov 2026 | 1 articles | Viewed by 1888 | Submission Open
Keywords: polyoxometalates; POMs; metal cluster compound; inorganic chemistry; nanocrystals
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Plant Responses to Abiotic and Biotic Stresses: 2nd Editon
edited by and
submission deadline 20 Nov 2026 | 1 articles | Viewed by 1747 | Submission Open
Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism
(This special issue belongs to the Section Molecular Plant Sciences)
Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms
edited by
submission deadline 20 Nov 2026 | 2 articles | Viewed by 1674 | Submission Open
Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Marine Natural Products as a Source of Therapeutics—Recent Trends
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 1546 | Submission Open
Keywords: marine natural products; marine-associated microbes; antimicrobial drug; antibiotics; marine-derived peptides; anti-inflammatory; molecular pharmacology; targeted therapies; extraction
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Sepsis: Molecular and Biochemical Perspectives submission deadline 20 Nov 2026 | 1 articles | Viewed by 1428 | Submission Open
Keywords: sepsis; outcome; molecular diagnosis; machine learning; biochemical biomarkers; targeted immunotherapy; personalized medicine; sepsis inflammatory endotypes
(This special issue belongs to the Section Biochemistry)
Radiobiology: New Challenges and Advances
edited by and
submission deadline 20 Nov 2026 | 1 articles | Viewed by 1371 | Submission Open
Keywords: strategies for overcoming cancer radioresistance and normal-tissue damage mitigation; combined approaches: BNCT, proton–boron capture therapy, radioimmunotherapy; emerging technologies and novel temporal regimes: FLASH RT mechanisms and radiobiology of laser-accelerated particles; radiobiology of new ions and of novel dose-delivery modalities in particle radiotherapy; limphopoenia in radiotherapy and biomarkers of radiation response; three-dimensional models; microdosimetry: standardising measurements; DNA damage/repair; tumour microenvironment: autophagy, ferroptosis, fibroblast activation protein; non-cancer effects and non-targeted effects
(This special issue belongs to the Section Molecular Biology)
Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 1163 | Submission Open
Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Biophysical Studies of Protein Structure-Function Relationships
edited by , and Velia Minicozzi
submission deadline 20 Nov 2026 | 1 articles | Viewed by 1065 | Submission Open
Keywords: protein structure; molecular dynamics; computational modeling; drug discovery
(This special issue belongs to the Section Molecular Biophysics)
Dietary Polyphenols and Human Health
edited by
submission deadline 20 Nov 2026 | 2 articles | Viewed by 981 | Submission Open
Keywords: natural polyphenols; health and disease; neurodegenerative diseases; gut microbiota; lowest effective dose; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges submission deadline 20 Nov 2026 | 1 articles | Viewed by 963 | Submission Open
Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy
(This special issue belongs to the Section Materials Science)
Molecular Understanding Involved in Age-Related Diseases submission deadline 20 Nov 2026 | 1 articles | Viewed by 937 | Submission Open
Keywords: sirtuins; frailty; aging; age-related diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 859 | Submission Open
Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies
(This special issue belongs to the Section Molecular Oncology)
Human Meningioma: Recent Developments
edited by Jason P. Sheehan, Yuki Shinya and Stylianos Pikis
submission deadline 20 Nov 2026 | Viewed by 746 | Submission Open
Keywords: meningioma; molecular pathogenesis; genomic alteration; radiogenomics; tumor microenvironment; biomarkers; neurosurgery; radiosurgery; translational neuroscience; artificial intelligence
(This special issue belongs to the Section Molecular Oncology)
Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases: 2nd Edition
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 609 | Submission Open
Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease
(This special issue belongs to the Section Molecular Biology)
The Involvement of the Ubiquitin Proteasome System in the Healthy and Diseased Heart
edited by
submission deadline 20 Nov 2026 | Viewed by 525 | Submission Open
Keywords: UPS; ubiquitin; proteasome; cardiac pathophysiology; coronary ischemia/reperfusion injury; heart failure; cardiomyopathies; E334K mutation; cMyBPC; electrophysiological dysfunction; hypertrophic cardiomyopathy; pharmacological targeting
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy
edited by Ilaria Marrocco and
submission deadline 20 Nov 2026 | Viewed by 506 | Submission Open
Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Hepatic Amino Acid Catabolism
edited by Carolina Conter
submission deadline 20 Nov 2026 | Viewed by 455 | Submission Open
Keywords: amino acid catabolism; essential amino acids; non-essential amino acids; liver metabolism; urea cycle; gluconeogenesis; lipid metabolism; nutritional regulation; mTOR signaling; metabolic diseases
(This special issue belongs to the Section Biochemistry)
Bioactive Compounds in Foods: From Structural Profiling to Bioavailability and Health Benefits
edited by Cong Wang
submission deadline 20 Nov 2026 | Viewed by 449 | Submission Open
Keywords: food bioactives; profiling; bioactive compounds; characterization; bioavailability; bioaccessibility; functionality; health-promoting benefits; structure/constituents–bioactivity relationship
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Regulation of Gene Expression in Cell Differentiation
edited by
submission deadline 20 Nov 2026 | Viewed by 442 | Submission Open
Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Tau Pathology Mechanisms and Therapeutic Interventions
edited by
submission deadline 20 Nov 2026 | Viewed by 399 | Submission Open
Keywords: tau; misfolding; neurodegeneration; Alzheimer’s disease; oligomer; tauopathies; therapies; hyperphorphorylation; frontotemporal lobe dementia; synapses; spreading
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Stress Resilience: Unveiling Mechanisms and Mitigation Strategies
edited by
submission deadline 20 Nov 2026 | Viewed by 376 | Submission Open
Keywords: plant stress resilience; abiotic stress; biotic stress; stress signaling pathways; biostimulants; genetic and molecular mechanisms; crop improvement; GMO
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Cardiomyopathy
edited by
submission deadline 20 Nov 2026 | Viewed by 366 | Submission Open
Keywords: cardiomyopathy; inflammation; molecular mechanisms; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Delivery for Human Diseases: From Basic Research to Clinical Applications
edited by
submission deadline 20 Nov 2026 | Viewed by 200 | Submission Open
Keywords: drug delivery systems; nanomedicine; targeted therapy; traditional medicine; translational pharmaceutical research
(This special issue belongs to the Section Molecular Pharmacology)
The Impact of the Exposome on Gut Health: Deciphering Molecular Mechanisms and Pathophysiological Pathways
edited by
submission deadline 20 Nov 2026 | Viewed by 190 | Submission Open
Keywords: exposome (internal & external); molecular gastroenterology; intestinal barrier function; gut-microbiota-host crosstalk; environmental toxicology; signal transduction pathways; nutritional epigenomics; metabolic dysregulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies of Colorectal Cancer: 5th Edition submission deadline 20 Nov 2026 | Viewed by 163 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Latest Molecular Discoveries of Arthropod-Borne Viruses
edited by Henry Puerta-Guardo
submission deadline 20 Nov 2026 | Viewed by 156 | Submission Open
Keywords: arbovirus; whole genome sequencing; pathogenesis; transcriptomics; CRISPR-Cas9; in silico; antivirals; vaccines; diagnostics
(This special issue belongs to the Section Molecular Microbiology)
Advances in Olfactory Neurobiology, Adult Neurogenesis and Dopaminergic Neuron Research
edited by
submission deadline 20 Nov 2026 | Viewed by 129 | Submission Open
Keywords: olfaction; olfactory bulb; dopaminergic neurons; Parkinson’s disease; Alzheimer’s disease; adult neurogenesis; early biomarker; neurodegenerative disease; smell impairment; smell test
(This special issue belongs to the Section Molecular Neurobiology)
Role of MicroRNAs in Human Diseases: 2nd Edition
edited by
submission deadline 25 Nov 2026 | 10 articles | Viewed by 20033 | Submission Open
Keywords: microRNAs, miRNAs, miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials
(This special issue belongs to the Section Molecular Genetics and Genomics)
Nutrition and Cardiovascular Development, from Fetal Origins to Adulthood
edited by
submission deadline 25 Nov 2026 | Viewed by 319 | Submission Open
Keywords: fetal programming; developmental origins of health and disease; maternal nutrition; placental function; offspring; cardiovascular function; cardiometabolic risk; cardio renal development; essential fatty acids; linoleic acid
(This special issue belongs to the Section Molecular Biology)
Novel Antiviral Agents: Challenges and Opportunities from Molecular Targeting to Validation submission deadline 25 Nov 2026 | Viewed by 208 | Submission Open
Keywords: antiviral agents; molecular targeting; virus–host interactions; drug repurposing; host-directed antivirals; combination therapy; antiviral resistance; translational virology
(This special issue belongs to the Section Molecular Pharmacology)
Advanced 3D-Bioprinting for Next-Generation In Vitro Models: Molecular and Technological Perspectives submission deadline 25 Nov 2026 | Viewed by 195 | Submission Open
Keywords: 3D bioprinting; in vitro models; biofabrication; bioinks; hydrogels; disease modeling; toxicology; drug screening; biomaterials; organ-on-a-chip
(This special issue belongs to the Section Macromolecules)
Nanomaterial: Synthesis and Application
edited by
submission deadline 25 Nov 2026 | Viewed by 171 | Submission Open
Keywords: nanomaterials; green synthesis; surface functionalization; nanoparticle engineering; drug delivery systems; energy storage; catalysis; environmental remediation; biocompatibility; molecular nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
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