Biomolecular Condensates and Their Role in Cellular Organization and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 127
Special Issue Editor
Special Issue Information
Dear Colleagues,
Recently, there has been an emphasis on the role of phase-separated biomolecular condensates and membrane-less organelles in eukaryotic cells. It has been shown that regulating and controlling distinct extracellular and intracellular microenvironments is necessary for maintaining many cellular processes and keeping the cells in homeostasis. Examples of such organelles include the nucleoli, sites of ribosome assembly in the nucleus; Cajal bodies, which assemble spliceosomes; centrosomes, which nucleate microtubules; and stress granules, which exist in different forms depending on stress conditions. The formation of intracellular membrane-less compartments occurs via a process called liquid–liquid phase separation in which a homogeneous solution spontaneously separates into two phases, a dense and dilute phase. Scientific reports also reveal that biocondensates are related to many diseases such as cancer, neurodegeneration, and others. This became the reason why the fields of biocondensates, membrane-less organelles, and liquid–liquid phase separation are growing at a very fast pace.
This Special Issue of the International Journal of Molecular Sciences entitled “Biomolecular Condensates and Their Role in Cellular Organization and Disease” will cover a wide range of research dedicated to the different aspects of liquid–liquid phase separation, biomolecular condensates, and membrane-less organelles in physiology and disease. It aims at collecting recent findings and comprehensive reviews from experts and will be a useful source of information for researchers.
Dr. Anna Bratek-Skicki
Guest Editor
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Keywords
- biocondensates
- membrane-less organelles
- liquid-liquid phase separation
- protein aggregation
- neurogenerative diseases
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