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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer

edited by

Katharina M. Robertson

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7228 | Submission Open

Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7189 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Genomic Aspects of Viral Pathogens

edited by

Joanna Dąbrowska

submission deadline 31 Oct 2026 | 4 articles | Viewed by 6368 | Submission Open

Keywords: viral pathogens; genetic and molecular mechanisms; viral infection; viral replication; host interaction

(This special issue belongs to the Section Molecular Microbiology)

Molecular Pathways to Infertility

edited by

Apostolos Kaponis

submission deadline 31 Oct 2026 | 5 articles | Viewed by 6152 | Submission Open

Keywords: infertility; molecules; meiotic arrest; premature ovarian insufficiency; sperm function; progesterone resistance; mitochondrial dysfunction; epigenetic dysregulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 31 Oct 2026 | 3 articles | Viewed by 6067 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Bone and Cartilage Injury and Repair: Molecular Aspects

edited by Silvia María Díaz-Prado

submission deadline 31 Oct 2026 | 2 articles | Viewed by 5832 | Submission Open

Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Reproduction and Fertility of Aquatic Animals: 3rd Edition

edited by

Hui Qiao

and Hongtuo Fu

submission deadline 31 Oct 2026 | 5 articles | Viewed by 5440 | Submission Open

Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture

(This special issue belongs to the Section Molecular Biology)

Biosensors: Emerging Technologies and Real-Time Monitoring

edited by Velmurugan Thavasi

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5306 | Submission Open

Keywords: biosensors; real-time monitoring; wearable sensors; electrochemical detection; optical biosensors; point-of-care (POC) diagnostics; biomarker identification and analysis; wireless technologies

(This special issue belongs to the Section Biochemistry)

Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis

edited by

Younseong Song

submission deadline 31 Oct 2026 | 4 articles | Viewed by 5002 | Submission Open

Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology

(This special issue belongs to the Section Molecular Biology)

Metabolic Dynamics and Immune Surveillance in the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 31 Oct 2026 | 5 articles | Viewed by 4791 | Submission Open

Keywords: cancer; TME; metabolism; immune cells; signaling pathway; therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Vaccine Immunology

edited by

Michael Eller

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4621 | Submission Open

Keywords: vaccine-induced immunity; systems vaccinology; single-cell immune profiling; multiomics; correlates of Protection; innate immunity; adjuvants; artificial Intelligence; immunomodulation; tissue-specific immune activation

(This special issue belongs to the Section Molecular Immunology)

Proteases and Their Inhibitors

edited by

Dominique Belin

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4547 | Submission Open

Keywords: protease; serine proteases; thiol proteases; acid proteases; metalloproteases; protease inhibitor; SERPINs

(This special issue belongs to the Section Biochemistry)

Computational Studies of Natural Products

edited by

Leonid B. Krivdin

submission deadline 31 Oct 2026 | 4 articles | Viewed by 3992 | Submission Open

Keywords: computational chemistry; natural products; structural elucidation; Nuclear Magnetic Resonance (NMR); Density Functional Theory (DFT)

(This special issue belongs to the Section Molecular Informatics)

Advances in Laboratory Animal Research for Precision Medicine in Cardiovascular Diseases

edited by Conrado Calvo

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3393 | Submission Open

Keywords: cardiovascular disease; experimental models and research; arrhythmias and cardiac electrophysiology; molecular science and imaging techniques; myocardial ischemia and heart failure; cardiac fibrillation and sudden cardiac death; circulation and blood vessels; diabetes and metabolic disorders; experimental datasets for precision medicine; data-driven in silico approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Peripheral Nerve Regeneration—2nd Edition

edited by

Cinzia Fabrizi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3378 | Submission Open

Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth

(This special issue belongs to the Section Molecular Neurobiology)

Hormonal and Metabolic Markers in Health and Disease

edited by

Rafał Podgórski

and

Kornelia Łach

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3176 | Submission Open

Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Role of the Gut-Islet Axis in and Beyond Metabolic Diseases

edited by Simona Georgiana Popa

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3173 | Submission Open

Keywords: entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes; neuroprotection; aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Evolutionary Genomics in Plants: From Single Gene to Genome

edited by

Bei Gao

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3108 | Submission Open

Keywords: evolutionary genomics; plant adaptation; genome evolution; crop improvement; bioinformatics; polyploidy

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Mechanisms of Receptor Activation

edited by

Zong Jie Cui

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2931 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure–function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Liver Disease: Pathogenesis, Progression, and Therapeutic Strategies

edited by

Andrea Dalbeni

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2859 | Submission Open

Keywords: liver disease; molecular pathogenesis; therapeutic strategies; liver fibrosis; hepatocellular carcinoma; MASLD and MetALD; molecular biomarkers; tailored medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Viral Epidemics

edited by Nikolaos Siafakas

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2807 | Submission Open

Keywords: emerging viruses; diagnostic virology; viral epidemiology; viral evolution; zoonotic infections; public health; surveillance

(This special issue belongs to the Section Molecular Microbiology)

Adipose Tissue as a Central Driver of Obesity-Related Complications

edited by

Anca Pantea Stoian

and

Teodor Salmen

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2717 | Submission Open

Keywords: obesity; adipose tissue; adipokine; cardiometabolic disease; metabolic complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis, 3rd Edition

edited by

Athina Geronikaki

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2670 | Submission Open

Keywords: enzyme; enzyme inhibitor; drug target; enzyme deficiency; enzyme overexpression; biomarker; drugs; diagnosis; therapy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Genetic Research in Skin Diseases

edited by

Yiannis Vasilopoulos

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2528 | Submission Open

Keywords: inflammatory skin diseases; genome-wide association studies (GWAS); epigenetic modifications; multi-omic integration; precision dermatology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Cellular Research on Taste Receptors

edited by

Ana R. Costa

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2496 | Submission Open

Keywords: taste receptors; taste signaling; gustatory system; molecular signaling; cellular mechanisms; health and disease; functional roles; neurobiology of taste; cancer biology and metastasis; translational research

(This special issue belongs to the Section Molecular Biology)

Tumor Markers and Tumor Microenvironment

edited by Tamás Micsik

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2474 | Submission Open

Keywords: tumor markers; tumor environment; molecular and genetics; omics; artificial intelligence; digital pathology; computational pathology; individualized therapy; prognostication

(This special issue belongs to the Section Molecular Oncology)

Interplay Between Blood Cells and Cytokines

edited by

Mats B. Eriksson

and

Anders O. Larsson

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2469 | Submission Open

Keywords: blood cells; communication; cytokine; erythrocyte; immunology; inflammation; interplay; leucocyte; platelet; network

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Next-Generation Antimicrobials and Anticancer Agents: From Natural to Synthetic Compounds

edited by

Manuela E. Crisan

and Roxana Popescu

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2426 | Submission Open

Keywords: bioactive molecules; natural products; synthetic compounds; molecular design; antimicrobial agents; anticancer agents; drug-resistant infections; drug discovery

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapeutic Targets in Inflammation and Cancer Immunity

edited by

Hyuk Soon Kim

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2365 | Submission Open

Keywords: immune regulation; inflammation; cancer immunity; immunotherapy; cytokine signaling; therapeutic targets; immune evasion; antibody-based therapy; histamine; drug repositioning

(This special issue belongs to the Section Molecular Immunology)

Genome Editing in Autologous Stem Cells: From Bench to Bedside

edited by

Edina Poletto

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2321 | Submission Open

Keywords: genome editing; gene therapy; autologous transplant; preclinical studies; process development; scalability; quality control; manufacturing; regulatory compliance; IND-enabling studies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Pathophysiology of Sepsis (2nd Edition)

edited by

Vlad Pădureanu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2316 | Submission Open

Keywords: animal models; therapeutic concepts; biomarkers; sepsis; immune suppression; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Targeted Therapies and Evolving Treatment Paradigms in Non-Small Cell Lung Cancer

edited by Luis E. Raez

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2308 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); targeted therapies; human epidermal growth factor receptor 2 (HER2); mesenchymal-epithelial transition factor (MET); anaplastic lymphoma kinase (ALK); C-ROS oncogene 1 receptor tyrosine kinase (ROS1); rearranged during transfection (RET); neurotrophic tyrosine receptor kinase (NTRK); B-Raf proto-oncogene serine/threonine kinase V600 mutation (BRAFv600); Kirsten rat sarcoma viral oncogene homolog (KRAS); epidermal growth factor receptor (EGFR)

(This special issue belongs to the Section Molecular Oncology)

Male Reproductive and Sexual Health

edited by

Aris Kaltsas

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2218 | Submission Open

Keywords: male reproductive health; male sexual health; male infertility; erectile dysfunction (ED); prostate inflammation; Peyronie's disease; biomarkers; molecular mechanisms; androgen deprivation; nanotechnology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes: 2nd Edition

edited by

Daniela Miricescu

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2192 | Submission Open

Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β; Ras/Raf/MEK/ERK; Wnt/β-catenin; angiogenesis; invasion; metastasis; inhibitors

(This special issue belongs to the Section Molecular Oncology)

Artificial Intelligence and Deep Learning in Biomedical and Molecular Research

edited by

Serhat Kılıçarslan

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2138 | Submission Open

Keywords: machine learning; deep learning; image processing; bioinformatics; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Extraction and Application of Natural Compound

edited by

Sakaewan Ounjaijean

submission deadline 31 Oct 2026 | 4 articles | Viewed by 2116 | Submission Open

Keywords: natural compounds; extraction; characterization

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanobiology of the Cell

edited by

Zbigniew Baster

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2046 | Submission Open

Keywords: nuclear and chromatin mechanics; mechanobiology; mechanotransduction pathways

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2004 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Applications of Polysaccharides in Biomedicine and Agriculture

edited by

Artur Valente

and

Edvani C. Muniz

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1993 | Submission Open

Keywords: polysaccharides; carbohydrates; oligosaccharides; biomedical applications; pharmaceutical applications; drugs

(This special issue belongs to the Section Macromolecules)

Biological Materials: Molecular Mechanisms, Tissue Responses, and Translational Perspectives

edited by

Andre Luiz Sena Guimaraes

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1980 | Submission Open

Keywords: biological materials; biomaterials; molecular mechanisms; regenerative medicine; 4D biomaterials; living materials; extracellular vesicle-based systems; advanced delivery systems; scalable manufacturing; translational medicine

(This special issue belongs to the Section Materials Science)

Unravelling Functional Biology in Retinal Dystrophies and Eye Disease

edited by

Luigi Donato

and

Simona Alibrandi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1970 | Submission Open

Keywords: precision ophthalmology; inherited retinal diseases; functional genomics; multi-omics approaches; photoreceptor degeneration; retinal organoids and iPSC models; bioinformatics and systems biology; genotype–phenotype correlations; RNA therapeutics and gene editing; early and late biomarkers of retinal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Infections and Novel Biological Molecules for Treatment: 2nd Edition

edited by Matthew Cheesman

submission deadline 31 Oct 2026 | 5 articles | Viewed by 1947 | Submission Open

Keywords: microbial infections; infectious diseases; new antibiotics; antimicrobial resistance (AMR); antimicrobial drugs; active substance; bacterial; virus

(This special issue belongs to the Section Molecular Microbiology)

Latest Research on Mesenchymal Stem Cells (2nd Edition)

edited by Marcel Costuleanu

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1924 | Submission Open

Keywords: mesenchymal stem cell; MSC; niche; tissue homeostasis; exosomes; microvesicles; cancer; mitochondrial exchange; MSC secretome

(This special issue belongs to the Section Molecular Biology)

Molecular Advances on Gut Microbiota in Human Health

edited by

Sanda Cretoiu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1757 | Submission Open

Keywords: gut microbiota; dysbiosis; metabolomics; host–microbe interaction; molecular pathways; inflammation; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Molecular Biology of Foodborne Pathogens: Genomics, Resistance, and New Perspectives

edited by

Joanna Gajewska

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1751 | Submission Open

Keywords: foodborne pathogens; antibiotic resistance; virulence factor; virulence genes; gene expression; bioinformatics; whole geomic sequencing

(This special issue belongs to the Section Molecular Microbiology)

Antibody-Based Therapeutics for Autoimmune Diseases

edited by

Naim Mahroum

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1702 | Submission Open

Keywords: autoimmune diseases; antibody-based therapeutics; autoantibodies; immunotherapy; precision medicine

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Biology of Germ Cells

edited by

Anna Tabęcka-Łonczyńska

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1659 | Submission Open

Keywords: germ cell development; meiosis; epigenetic regulation; autophagy; mitochondrial dynamics; infertility; reproductive medicine; germ cell tumors; steroidogenesis; endocrine disrupting chemicals; reproductive toxicity

(This special issue belongs to the Section Molecular Biology)

Transcriptional Regulation in Plant Development: 3rd Edition

edited by

Konstantinos E. Vlachonasios

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1620 | Submission Open

Keywords: environmental stresses; plant development; vegetative development; plant physiology and biochemistry; transcriptional regulation; plant–environment interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Andrology

edited by Elikanah Olusayo Adegoke

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1603 | Submission Open

Keywords: fertilty; assisted reproduction technology; endocrine disrupting chemicals; hormones; male reproductive aging; semen analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cotton Breeding and Genetics: Advances and Perspectives

edited by Xuwu Sun

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1598 | Submission Open

Keywords: molecular design breeding; smart breeding; CRISPR-Cas; artificial intelligence; cotton genomics; multi-omics; high-throughput phenotyping; trait prediction; genome editing; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 901-950 on page 19 of 62.

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