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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Progress in Extracellular Vesicles submission deadline 20 Apr 2026 | 2 articles | Viewed by 1655 | Submission Open
Keywords: extracellular vesicles (EVs); macrovesicles; exosomes; cell– cell comunication
(This special issue belongs to the Section Molecular Biology)
Updates and Advances in the Field of Glioblastomas: Mechanisms, Microenvironment and Treatments
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 1613 | Submission Open
Keywords: GBM; molecular classification; pediatric diffuse gliomas; signaling pathways in GBMs; recurrent gliomas; midbrain gliomas; immunotherapy; targeted therapies for GBMs
(This special issue belongs to the Section Molecular Oncology)
Trace Elements, Metals and Bioactive Compounds: Homeostasis and Metabolic Impairment submission deadline 20 Apr 2026 | 1 articles | Viewed by 1601 | Submission Open
Keywords: trace elements; bioactive compounds; metals; human health; human diseases
(This special issue belongs to the Section Biochemistry)
New Perspectives on Prostate Cancer Occurrence, Diagnosis, and Treatment submission deadline 20 Apr 2026 | 1 articles | Viewed by 1598 | Submission Open
Keywords: prostate cancer; biomarker; diagnosis; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Regulatory Mechanisms in the Hypoxic Environment
edited by Irene Filippi
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1579 | Submission Open
Keywords: hypoxia; hypoxia-inducible factors (HIFs); angiogenesis; metabolic adaptation; autophagy; cell survival; chronic obstructive pulmonary disease (COPD); cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plants Redox Biology
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1569 | Submission Open
Keywords: plant– environment interaction; stress physiology; plant redox signaling; plant hormones; plant– pathogen interaction; reactive oxygen species (ROS); reactive nitrogen species (RNS); ascorbate; flavonoid; glutathione
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Studies of Muscle Contraction
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1541 | Submission Open
Keywords: muscle contraction; actin; myosin; thin and thick filament; cytoskeletal anchoring protein
(This special issue belongs to the Section Molecular Biophysics)
Selected Papers from the 13th International Conference on Carbonic Anhydrases and Other Research submission deadline 20 Apr 2026 | 1 articles | Viewed by 1508 | Submission Open
Keywords: metalloenzymes; carbonic anhydrase; inhibitors; activators; pharmacology; SLC-0111; anticancer agents
(This special issue belongs to the Section Biochemistry)
Plant Physiology and Molecular Nutrition: 2nd Edition
edited by and
submission deadline 20 Apr 2026 | 2 articles | Viewed by 1457 | Submission Open
Keywords: plant nutritional physiology; nutrient signaling; phytohormones; gene regulation network; environment and nutrition crosstalk
(This special issue belongs to the Section Molecular Plant Sciences)
Innovative Therapeutic Approaches to Endocrine Disorders submission deadline 20 Apr 2026 | 1 articles | Viewed by 1452 | Submission Open
Keywords: endocrine disorders; osteoporosis; diabetes; obesity; synthetic drugs; nutraceuticals; biomarkers
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Future Challenges and Innovation in Gynecological Oncology submission deadline 20 Apr 2026 | 3 articles | Viewed by 1446 | Submission Open
Keywords: gynecologic oncology; molecular biomarkers; personalized medicine; ovarian cancer; immunotherapy; tumor microenvironment; drug resistance; translational research
(This special issue belongs to the Section Molecular Oncology)
Research on Plant-Microbe Interactions
edited by Lin Chen
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1441 | Submission Open
Keywords: beneficial microbes; rhizosphere; phyllosphere; endosphere; colonization; microbiome; root exudates; communication; secondary metabolites; plant immunity; environmental stress; resistance to plant disease
(This special issue belongs to the Section Molecular Plant Sciences)
Liver Diseases: From Pathophysiology to Novel Therapeutic Approaches
edited by Clare Selden
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1316 | Submission Open
Keywords: liver disease molecular mechanisms treatments for liver disease somatic cell therapy; ATMP medical device molecular approaches; molecular signatures; RNA therapies; “ omics” for liver disease pathobiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Latest Molecular Research on Renal Disease
edited by Niels Henrik Buus and Marco Eijken
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1311 | Submission Open
Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Environmental Influences on Cellular Responses
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1291 | Submission Open
Keywords: cell/environment interaction; cell signaling; mechanobiology; photobiology; thermobiology; enviromics; cell-cell communication; cell-cell interaction
(This special issue belongs to the Section Molecular Biology)
Interplay Between Blood Cells and Cytokines submission deadline 20 Apr 2026 | 1 articles | Viewed by 1288 | Submission Open
Keywords: blood cells; communication; cytokine; erythrocyte; immunology; inflammation; interplay; leucocyte; platelet; network
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Advances in Macroporous, Mesoporous, and Microporous Materials submission deadline 20 Apr 2026 | 2 articles | Viewed by 1284 | Submission Open
Keywords: functional materials; nanomaterials; nanostructures; molecular systems; porous materials
(This special issue belongs to the Section Materials Science)
Red Blood Cell Dysfunction and Hemodynamic Changes in Inflammation, Infection and Metabolic Disease
edited by Janette Bester
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1270 | Submission Open
Keywords: red blood cell; inflammation; infection; metabolic disease; hemodynamics
(This special issue belongs to the Section Molecular Biology)
Advances in Metabolomics for Animal Health and Nutrition submission deadline 20 Apr 2026 | 1 articles | Viewed by 1243 | Submission Open
Keywords: metabolomics; animal health; animal nutrition; biomarkers; mass spectrometry; NMR spectroscopy; precision nutrition
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Stem Cell Biology & Regenerative Medicine—2nd Edition
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1219 | Submission Open
Keywords: hiPSC; hES; Crispr; BBB; disease in a dish; neuro-regeneration; pain reliever; scaffold
(This special issue belongs to the Section Molecular Biology)
Genomics, Genetics, and the Future of Fruit Improvement
edited by Zoe Hilioti
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1174 | Submission Open
Keywords: fruit traits; genetics; genetic diversity; omics; new breeding techniques; fruit quality; shelf life
(This special issue belongs to the Section Molecular Plant Sciences)
Collagen and Its Derivatives in Tissue Engineering
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1172 | Submission Open
Keywords: collagen derivatives; tissue engineering; in vitro experiments; in vivo investigations; material degradation
(This special issue belongs to the Section Biochemistry)
Molecular Insights on Myogenic Progenitors: Regulation of Differentiation
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1171 | Submission Open
Keywords: myogenic progenitors; skeletal muscle; muscle regeneration; myogenesis
(This special issue belongs to the Section Molecular Biology)
Fiber Plants: Genetics and Genomics, Molecular Mechanisms and Potential Applications—Novel Materials, Functional Foods and Beyond submission deadline 20 Apr 2026 | 1 articles | Viewed by 1148 | Submission Open
Keywords: fiber plant; genetics; genomics; bioactive products; natural fibers; fatty acids; medical products; environmental and ecological effects of fiber plants
(This special issue belongs to the Section Molecular Plant Sciences)
Emerging Topics in Macromolecular Crystallography submission deadline 20 Apr 2026 | 1 articles | Viewed by 1138 | Submission Open
Keywords: macromolecular crystallography; structural biology; artificial intelligence; structure determination; molecular mechanism; functions; drug discovery; protein; nucleic acid; carbohydrates
(This special issue belongs to the Section Macromolecules)
Lung Cancer: From Molecular Mechanisms to Novel Therapeutics: 2nd Edition submission deadline 20 Apr 2026 | 1 articles | Viewed by 1130 | Submission Open
Keywords: lung cancer; oncogene; targeted therapy; immunotherapy; predictive biomarkers; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Current Advances in the Pathophysiology and Treatment of Multiple Sclerosis and Related Disorders
edited by Natalia Szejko and
submission deadline 20 Apr 2026 | Viewed by 1106 | Submission Open
Keywords: multiple sclerosis; MS; central nervous system; pathophysiology; immunological system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Venom Research
edited by Juliana Pavan Zuliani
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1099 | Submission Open
Keywords: venoms; toxins; biological activities; therapeutic potential; molecular mechanism; venomous animals; pharmacological effects
(This special issue belongs to the Section Molecular Toxicology)
Multiple Sclerosis: From Molecular Mechanisms to Pathophysiology
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1084 | Submission Open
Keywords: multiple sclerosis; pathogenesis; blood– brain barrier; cellular pathways; neurodegeneration; biomarkers; gene– environment interaction; astrocytes; glia
(This special issue belongs to the Section Molecular Neurobiology)
The Interaction Between Cell and Virus, 3rd Edition
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1082 | Submission Open
Keywords: viral replication; gene expression; lytic infection; viral structure; viral assembly; cell signaling pathway; post-translational modification; immune evasion; viral tumorigenesis; antiviral medication
(This special issue belongs to the Section Molecular Microbiology)
Preimplantation Genetic Testing in Assisted Reproductive Technologies
edited by
submission deadline 20 Apr 2026 | Viewed by 1076 | Submission Open
Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Emerging Viral Epidemics
edited by Nikolaos Siafakas
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1072 | Submission Open
Keywords: emerging viruses; diagnostic virology; viral epidemiology; viral evolution; zoonotic infections; public health; surveillance
(This special issue belongs to the Section Molecular Microbiology)
Advances in Molecular Research on Plant-Fungi Interactions
edited by Francisca Sempere-Ferre
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1061 | Submission Open
Keywords: plant– fungi interactions; mycorrhizal symbiosis; fungal pathogens; effector molecules; plant defense mechanisms; signal transduction; secondary metabolites; microbiome interactions; molecular plant biology; host– pathogen dynamics
(This special issue belongs to the Section Molecular Plant Sciences)
Ovarian Pathologies: Insights into Mechanisms and Therapeutic Strategy
edited by Anna Ptak
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1047 | Submission Open
Keywords: subfertility and infertility; hormonal dysfunction; diminished ovarian reserve (DOR); ovarian cysts; polycystic ovary syndrome (PCOS); primary ovarian insufficiency (POI); ovarian cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Approaches in Drug Discovery: From Natural Products to Therapeutic Innovations
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1043 | Submission Open
Keywords: natural product-derived compounds; drug discovery; medicinal chemistry; disease prevention; therapeutic innovation; artificial intelligence in drug discovery; high-throughput screening; omics technologies; drug delivery systems; novel therapeutic strategies
(This special issue belongs to the Section Molecular Pharmacology)
Novel Genotypes and Experimental Advances in Xenotransplantation
edited by Konrad Fischer
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1024 | Submission Open
Keywords: xenotransplantation; genetic engineering; preclinical models; genetically modified donor organs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeting Cancer Metabolism: From Mechanism to Therapies
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1018 | Submission Open
Keywords: cancer metabolism; metabolic alterations; Warburg effect; metabolic reprogramming; metabolic disorder; mitochondrial dysfunction; mitochondrial dynamics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Molecular Mechanism in Infertility
edited by and Andrea Etrusco
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1017 | Submission Open
Keywords: infertility; molecular mechanisms; reproductive biology; genomics; epigenetics; biomarkers; assisted reproductive technologies; transcriptomics; proteomics; environmental factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioinspired and Emerging Functionalized Nanostructures for Precision Drug Delivery submission deadline 20 Apr 2026 | 1 articles | Viewed by 1016 | Submission Open
Keywords: nanostructured materials; nanobiomaterials; nanocomposites; drug delivery systems; targeted therapies; controlled release; responsive functionalities; theranostics; biomedical applications; therapeutic innovations; bioinspired nanostructures; personalized medicine
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer
edited by
submission deadline 20 Apr 2026 | Viewed by 1016 | Submission Open
Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer
(This special issue belongs to the Section Molecular Neurobiology)
Role of MicroRNAs in Health and Diseases
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1012 | Submission Open
Keywords: miRNA; cancer; biomarkers; function; miRNA target
(This special issue belongs to the Section Molecular Genetics and Genomics)
Sex and Gender Medicine—Physiology: A New Horizon in Human Physiology
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1011 | Submission Open
Keywords: sex and gender; personalized medicine; sex-specific evidence; sex-specific differences
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research and Recent Advances of Antimicrobials
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1007 | Submission Open
Keywords: antibiotic; antibacterial; antifungal; antiviral; chemical synthesis; drug discovery; natural products; small molecules; peptides; proteins; oligosaccharides; polysaccharides; drug delivery; nanoparticles; solutions; gels; formulation; nanoparticles; materials; coat-ings; drug release; structure– activity; mechanism of action; clinical application; veterinary applications; agricultural applications; food preservation
(This special issue belongs to the Section Molecular Pharmacology)
Exploring Therapeutic Targets in the Evolving Landscape of Cancer Immunotherapy: 2nd Edition
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1003 | Submission Open
Keywords: immune checkpoints; targeted therapies; tumor microenvironment; cancer immunology; precision medicine; cell-based cancer therapy
(This special issue belongs to the Section Molecular Immunology)
Hemolytic Anemia: From Molecular Mechanisms to Therapeutic Exploitation
edited by Joan-Lluis Vives-Corrons
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1002 | Submission Open
Keywords: hemolytic anemias; red blood cells; sickle cell disease; targeted therapies; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights in Metabolomics: Chromatography and Mass Spectrometry Applications in Cancer Research submission deadline 20 Apr 2026 | 1 articles | Viewed by 983 | Submission Open
Keywords: metabolomics; chromatography; mass spectrometry; molecular oncology; cancer pathways; precision medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Role of Endocrine Disruptors in Immune Diseases
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 973 | Submission Open
Keywords: endocrine disruptors; immune disease; cytokine signaling; autoimmunity; immunotoxicity; epigenetic modulation; hormone receptors; inflammation; environmental toxicology; EDC exposure
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Artificial Intelligence in Molecular Biomarker Screening
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 947 | Submission Open
Keywords: molecular biomarkers; imaging biomarkers; screening; artificial intelligence; metaverse
(This special issue belongs to the Section Molecular Informatics)
Chemical Elicitors and Microbial Metabolites: Synergistic Mechanisms in Plant Systemic Resistance Induction
edited by Heewan Kang
submission deadline 20 Apr 2026 | 1 articles | Viewed by 937 | Submission Open
Keywords: chemical elicitors; Bacillus spp.; microbial metabolites; amino acids; defense induction; resistance mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Cellular and Molecular Biology of Cardiac Hypertrophy and Heart Failure: Pathogenesis, Diagnostics and Treatment—2nd Edition
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 855 | Submission Open
Keywords: cardiac hypertrophy; myocardial remodelling; heart failure; cellular mechanisms; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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