Liver Diseases: From Pathophysiology to Novel Therapeutic Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 145
Special Issue Editor
Special Issue Information
Dear Colleagues,
The prevalence of liver disease is increasing worldwide. More than sixty years ago, Thomas Starzl performed the first whole-organ liver transplant, which was successfully repeated in the UK and Europe within 5 years. Transplantation can be curative for many patients; however, donor organs are limited and many patients do not receive this curative treatment. Nonetheless, new treatments for liver disease are crucial as liver disease is widespread and growing. Recent advances in understanding the pathophysiology of many liver diseases offer hope for many new therapeutic approaches. With a better understanding of disease pathology at the molecular level, ideas that were a pipe dream 20 years ago are becoming a reality today. Examples in liver disease include anti-fibrotic and cirrhosis-resolving pharmaceuticals. Novel cell therapies in liver cancer include immune modulation therapies and somatic cell therapies, or the use of RNA nanomedicine, wherein gene or protein expression is altered without a corresponding alteration in DNA sequences. Moreover, several delivery technologies are required for these new treatments to be used in patients, whether they be medical devices, nano-carriers, GalNAc based conjugates that target the asialo-glycoprotein receptor, cell and organoid cryopreservation, or cell transplantation into a stem cell niche.
This Special Issue aims to bring together new technological approaches to produce and deliver novel therapies for liver disease as well as to further investigate the molecular patterns associated with liver disease using appropriate “omics” for exploring liver disease pathology further.
Dr. Clare Selden
Guest Editor
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Keywords
- liver disease molecular mechanisms treatments for liver disease somatic cell therapy
- ATMP medical device molecular approaches
- molecular signatures
- RNA therapies
- “omics” for liver disease pathobiology
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