Stem Cell Biology & Regenerative Medicine—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 715
Special Issue Editor
Interests: reprogramming; differentiation; Brain Blood Barrier (BBB); iPSC; drug discovery; disease in a dish model
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
More than 50% of pre-clinical studies fail despite a long and expensive journey of drug discovery using animal models.
Currently, there is a human-relevant replacement: human patient induced pluripotent stem cells (hiPSCs)/human embryonic stem cells (hESs) and their counterpart corrected cells using Crispr methodology, which enables the establishment of disease-in-a-dish models encompassing patients’ genetics.
We invite papers that use hiPSC/hES-derived cells (cardiomyocytes, fibroblasts, glial cells, neurons, astrocytes, brain microvascular endothelial cells and more) as disease models to screen leads for drugs.
Topics of interest include (but are not limited to) the following:
- hiPSC/hES-derived microglia/glia/astrocytes as models for screening anti-inflammation compounds.
- New materials for establishing hiPSC-derived three-dimensional (3D) scaffolds as platforms for drug discovery.
- Compounds that act as neuro-regeneration activators for cases like traumatic brain injury (TBI), Alzheimer’s disease, ALS, Parkinson’s disease and more.
- The hiPSC/hES-based blood–brain barrier (BBB) model as a tool for distinguishing between drugs that can penetrate/damage the BBB and drugs that failed in preclinical studies because they cannot penetrate the BBB.
- Identifying pain relievers by screening cannabis-derived compounds and other pain relievers using hiPSC/hES-derived sensory cells.
- Crispr methods to accurately correct/generate disease-related mutations in hiPSC/hES.
- Unique markers for identifying hiPSC/hES-derived cells in 3D-scaffold-based models.
Dr. Rivka Ofir
Guest Editor
Manuscript Submission Information
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Keywords
- hiPSC
- hES
- Crispr
- BBB
- disease in a dish
- neuro-regeneration
- pain reliever
- scaffold
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