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Selected Papers from the 13th International Conference on Carbonic Anhydrases...
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Selected Papers from the 13th International Conference on Carbonic Anhydrases and Other Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 301

Special Issue Editors

Prof. Dr. Claudiu T. Supuran

grade E-Mail Website
Guest Editor
NEUROFARBA Department, Sezione di Scienze Farmaceutiche, University of Florence, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, FI, Italy
Interests: drug design; metalloenzymes; carbonic anhydrases; anticancer agents; antiinfectives; sulfonamides; coumarins
Special Issues, Collections and Topics in MDPI journals
Dr. Óscar López

E-Mail Website
Guest Editor
Department of Organic Chemistry, University of Seville, Apartado 1203, 41012 Seville, Spain
Interests: medicinal chemistry; organic synthesis; enzyme inhibitors; antiproliferative agents; anti-Alzheimer's agents; polyphenols; iminosugars; coumarins; steroids; antioxidants; organoselenium compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The “13th International Conference on Carbonic Anhydrases” will be held in Seville, Spain, on 2nd-4th April 2025. The conference is being co-organized by the Faculty of Chemistry at the University of Seville, the NEUOFARBA Department of Florence University and the Istituto di Biostrutture e Bioimmagini-CNR in Naples. The symposium will bring together world-renowned scientists and will be a great opportunity to demonstrate the latest advances in carbonic anhydrases, including molecular biology, the design of inhibitors and activators, applications in diverse medical fields, and future trends.

This meeting will provide a framework for the gathering of international experts in the field, enabling the establishment of new collaborative networks, as well as the enjoyment of the beautiful and historic city of Seville. In addition to papers directly related to the presentations delivered during the conference, we invite all researchers whose work focuses on carbonic anhydrases to submit a manuscript to this Special Issue.

Prof. Dr. Claudiu T. Supuran
Dr. Óscar López
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metalloenzymes
  • carbonic anhydrase
  • inhibitors
  • activators
  • pharmacology
  • SLC-0111
  • anticancer agents

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Published Papers (1 paper)

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Research

13 pages, 1932 KiB  
Article
Acetazolamide-Loaded Nanoparticle Based on Modified Hyaluronic Acid as Delivery System to Target Carbonic Anhydrases in Escherichia coli
by Valentina Verdoliva, Viviana De Luca, Claudiu T. Supuran, Stefania De Luca and Clemente Capasso
Int. J. Mol. Sci. 2025, 26(10), 4908; https://doi.org/10.3390/ijms26104908 - 20 May 2025
Abstract
Acetazolamide (AZA) is a validated carbonic anhydrase inhibitor (CAI) that has the potential for use in various therapeutic applications. Herein, we report a novel AZA-loaded biodegradable nanodelivery system that was proven to enhance the antibacterial efficacy of the drug against Gram-negative bacteria, such [...] Read more.
Acetazolamide (AZA) is a validated carbonic anhydrase inhibitor (CAI) that has the potential for use in various therapeutic applications. Herein, we report a novel AZA-loaded biodegradable nanodelivery system that was proven to enhance the antibacterial efficacy of the drug against Gram-negative bacteria, such as Escherichia coli. Carbonic anhydrases (CA, EC 4.2.1.1) in E. coli play a crucial role in bacterial metabolism and CO2/HCO3− balance; therefore, they represent a suitable target for antimicrobial strategies. The nanoparticles were obtained using a green synthetic protocol that allowed conjugation of a natural fatty acid to hyaluronic acid (HA) under solvent-free conditions. Full characterization of the micellar aggregates was performed (diameter of the micelles, zeta potential, and drug release study). In vitro studies demonstrated that AZA loaded in HA-based nanoparticles significantly inhibited E. coli growth at concentrations as low as 0.5 µg/mL, whereas higher concentrations of free AZA were required, as previously reported. Additionally, encapsulated AZA disrupted glucose consumption in E. coli, indicating its profound impact on bacterial metabolism. These findings suggest that the HA–palmitate nanoparticle not only enhances the delivery and efficacy of AZA but also offers a strategy to affect bacterial metabolism. Full article
(This article belongs to the Special Issue Selected Papers from the 13th International Conference on Carbonic Anhydrases and Other Research)
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