Red Blood Cell Dysfunction and Hemodynamic Changes in Inflammation, Infection and Metabolic Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 163
Special Issue Editor
Interests: red blood cells (RBCs); hemodynamics; coagulation; inflammation; metabolic diseases; cellular pathophysiology; blood rheology; clotting kinetics; erythrocyte dysfunction
Special Issue Information
Dear Colleagues,
During inflammation RBCs are frequently exposed to oxidative stress and damage from cytokines, resulting in altered morphology, reduced deformability, and increased aggregation. These modifications impair oxygen transport and contribute to complications such as tissue hypoxia. Furthermore, RBCs undergoing eryptosis result in anemia, further exacerbating oxygen delivery issues. During infections, RBCs interact with pathogens and immune molecules, facilitating pathogen clearance but potentially intensifying systemic inflammation.
Hemodynamic alterations in these conditions are equally critical. Inflammation and RBC aggregation elevate blood viscosity, disrupting microcirculation and impairing tissue perfusion. Such effects are magnified in metabolic diseases, such as diabetes, where endothelial dysfunction and hyperglycemia further hinder RBC functionality and blood flow. Moreover, in severe inflammatory conditions, such as sepsis, hemolysis and oxidative stress lead to profound systemic hypoperfusion and organ failure.
Chronic low-grade inflammation in metabolic disorders also contributes to RBC metabolic and structural abnormalities, diminishing oxygen delivery efficiency. Research increasingly focuses on elucidating these mechanisms to guide precision medicine approaches, aiming to mitigate complications associated with RBC dysfunction and hemodynamic disturbances in inflammation and metabolic diseases.
In this research topic, we welcome authors to submit Original Research, Review and Perspective articles related to the pathological changes in RBCs during inflammation, infection or metabolic diseases. Studies using human, animal or cell models are welcomed. We anticipate that this special issue will help to further define RBC dysfunction and hemodynamic changes in inflammation, infection and metabolic disease.
Prof. Dr. Janette Bester
Guest Editor
Manuscript Submission Information
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Keywords
- red blood cell
- inflammation
- infection
- metabolic disease
- hemodynamics
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