Novel Genotypes and Experimental Advances in Xenotransplantation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 123
Special Issue Editor
Interests: xenotransplantation; translational pig models; livestock engineering; immunology; allergy development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Xenotransplantation has emerged as a promising solution to the critical organ shortage, driven by advances in genetic engineering and preclinical models. This Special Issue explores cutting-edge developments in the field, focusing on novel genotypes and experimental methodologies that enhance transplant success. Key topics include the role of genetically modified donor organs, particularly with modifications targeting immune compatibility and oxidative stress regulation.
The series will further highlight tools for evaluating xenotransplant viability in a clinically relevant setting. Studies on genetic modifications to reduce rejection mechanisms, enhance organ longevity, and optimize metabolic pathways will be featured. Additionally, research on oxidative stress mechanisms in xenotransplantation will be discussed, with a focus on genes that regulate inflammatory and stress responses in donor and recipient tissues.
Other areas of interest include advances in immunosuppressive strategies, novel biomarkers for xenograft function, and emerging preclinical models that bridge the gap between experimental and clinical application. By showcasing these innovations, this Special Issue aims to provide a comprehensive overview of how novel genetic and experimental approaches are shaping the future of xenotransplantation.
Dr. Konrad Fischer
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- xenotransplantation
- genetic engineering
- preclinical models
- genetically modified donor organs
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