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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Evolving Landscape of Cardiovascular Pathophysiology

edited by

Pooja Shivshankar

submission deadline 25 Jul 2026 | Viewed by 86 | Submission Open

Keywords: biomarker discovery in cardiovascular pathophysiology; precision diagnostics-novel contrast agents combined with PET/CT; MRI; machine learning/AI and clinical implementations in cardiology; cardio-metabolic disease; inflammation and immunity in cardiovascular diseases; mechanisms of non-coding RNAs and microRNAs in cardiac diseases; translational research in large animals bridging the rodent re-search with human pathophysiology; targeted therapies- genetic therapies/gene editing approach (CRISPR); stem cell therapies; and therapeutic mRNA and siRNA-based approaches

(This special issue belongs to the Section Biochemistry)

Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 4th Edition

edited by

Zhidong Zhou

and

Alexandre Hiroaki Kihara

submission deadline 25 Jul 2026 | Viewed by 33 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial

(This special issue belongs to the Section Molecular Neurobiology)

Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 30 Jul 2026 | Viewed by 140 | Submission Open

Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Drug Resistance and Therapeutic Targets

edited by

Sanjay K. Srivastava

submission deadline 30 Jul 2026 | Viewed by 136 | Submission Open

Keywords: drug resistance; therapeutic targets; efflux transporters’ oncogenic signaling pathways; tumor microenvironment; dna damage/repair; personalized therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms Underlying Abiotic Stress Tolerance in Plants: From Gene Regulation to Adaptive Traits

edited by Shijiang Cao

submission deadline 30 Jul 2026 | 1 articles | Viewed by 114 | Submission Open

Keywords: forest molecular biology; tree physiology; plant developmental biology; plant-microbe interactions; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Bone Homeostasis

edited by

John Kelly Smith

submission deadline 30 Jul 2026 | Viewed by 107 | Submission Open

Keywords: bone remodeling; osteoblasts and osteoclasts; osteoimmunology; osteometabolism; signaling pathways; bone diseases; epigenetic regulation; extracellular vesicles; mechanotransduction; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Phytochemicals and Antioxidants on Health and Disease Modulation

edited by Natalia Kurhaluk

submission deadline 30 Jul 2026 | Viewed by 74 | Submission Open

Keywords: phytochemical bioactive compounds; antioxidant mechanisms; oxidative stress modulation; chronic disease prevention; inflammatory signalling pathways; molecular health effects; bioavailability and metabolism; flavonoid biological activity; polyphenol therapeutic potential; disease modulation strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Omics-Driven Advances in Plant Abiotic Stress Tolerance

edited by

Kincső Decsi

submission deadline 30 Jul 2026 | Viewed by 52 | Submission Open

Keywords: omics; abiotic stressors; prevention; cellular biochemical changes; individual or genome-wide analyses

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Proteomics in Human Diseases and Infections: 2nd Edition

edited by

Mahamud Ur Rashid

submission deadline 30 Jul 2026 | Viewed by 47 | Submission Open

Keywords: proteomics; human diseases; infections; biomarkers; therapeutic targets; disease pathogenesis; host– pathogen interactions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunoregulatory Mechanisms of Gut Microbiota

edited by

José Fachi

submission deadline 30 Jul 2026 | Viewed by 45 | Submission Open

Keywords: gut microbiota; mucosal immunity; host– microbe interactions; immune homeostasis; dysbiosis; microbial metabolites; short-chain fatty acids; barrier function; colitis

(This special issue belongs to the Section Molecular Microbiology)

Natural Products for Cancer: Cutting-Edge Trends and Future Directions

edited by

Mounir Tilaoui

and Abdelmajid Zyad

submission deadline 30 Jul 2026 | Viewed by 40 | Submission Open

Keywords: natural products; cancer therapy; drug discovery; molecular mechanisms; multi-drug resistance; tumor heterogeneity; structure– activity relationships (SARs); biosynthetic pathway engineering; AI-driven drug discovery; multi-omics approaches

(This special issue belongs to the Section Molecular Pharmacology)

Immunoregulation of Abnormal Cell Proliferation: Molecular Mechanisms and Therapeutic Strategies

edited by

Xingkang Wu

submission deadline 30 Jul 2026 | Viewed by 39 | Submission Open

Keywords: immune microenvironment; cell proliferation; molecular mechanisms; therapeutic strategies; tumor; autoimmune disease; psoriasis; rheumatoid arthritis; lupus erythematosus; type 1 diabetes; inflammatory bowel disease

(This special issue belongs to the Section Molecular Immunology)

Application of Molecular Technology to Dental Treatment

edited by

Yoshiya Hashimoto

submission deadline 30 Jul 2026 | Viewed by 35 | Submission Open

Keywords: biotechnology; implant material; titanium; zirconia; PEEK; in vitro; in vivo

(This special issue belongs to the Section Materials Science)

From Molecular Understanding to Ecological Significance: Understanding Marine Reproductive Biology

edited by

Zohaib Noor

submission deadline 30 Jul 2026 | Viewed by 30 | Submission Open

Keywords: reproductive biology; gametogenesis; bivalves reproduction; biodiversity; endocrine regulation; gametogenesis; molecular signaling; genomics; fertilization; population dynamics; ecological resilience

(This special issue belongs to the Section Molecular Biology)

Molecular Biomarkers in Oral Pathology

edited by

Ioannis Astreidis

and Konstantinos Paraskevopoulos

submission deadline 30 Jul 2026 | Submission Open

Keywords: oral disease; oral pathology; oral cancer; biomarkers; molecular biomarkers; head and neck pathology; precision medicine; omics-based analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Atherosclerosis: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Antonio Barbato

submission deadline 31 Jul 2026 | 3 articles | Viewed by 12962 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research on Antifungal Resistance

edited by Anna Tomova

submission deadline 31 Jul 2026 | 4 articles | Viewed by 6275 | Submission Open

Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis: 3rd Edition

edited by

Andreas Beineke

submission deadline 31 Jul 2026 | 4 articles | Viewed by 4669 | Submission Open

Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition

edited by

Yasemin M. Akay

submission deadline 31 Jul 2026 | 1 articles | Viewed by 4377 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification

edited by

Jose Miguel Laffita-Mesa

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1731 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; disease stratification; Parkinson’ s disease; Alzheimer’ s disease; spinocerebellar ataxia; precision medicine; digital PCR; circRNA; prognostic biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Systems Genetics of Metabolic Disorders: From Omics Signatures to Molecular Mechanisms

edited by

Seong-Hee Maria Ko

submission deadline 31 Jul 2026 | 1 articles | Viewed by 909 | Submission Open

Keywords: metabolic syndrome; single-nucleotide polymorphism (SNP); genome-wide association study (GWAS); copy number variation; diet; metabolomics; nutritional genetics; lipid metabolism; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition

edited by

De-Guo Han

submission deadline 31 Jul 2026 | 1 articles | Viewed by 627 | Submission Open

Keywords: plant– pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes

(This special issue belongs to the Section Molecular Plant Sciences)

Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies

edited by

Katarzyna Romanowska-Próchnicka

submission deadline 31 Jul 2026 | Viewed by 335 | Submission Open

Keywords: molecular mechanisms; immune signaling pathways; targeted therapies; biomarkers; autoimmune pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell–Cell Communication Through Extracellular Vesicles

edited by Federica Fratini

submission deadline 31 Jul 2026 | Viewed by 313 | Submission Open

Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape

(This special issue belongs to the Section Molecular Biology)

Cellular, Immune and Molecular Pathways of Injury and Disease in Forensic and Legal Medicine

edited by

Sorin Hostiuc

submission deadline 31 Jul 2026 | Viewed by 163 | Submission Open

Keywords: molecular autopsy; cellular injury pathways; ischemia and hypoxia markers; molecular profiling of fatal injuries; forensic genetics and toxicogenomic

(This special issue belongs to the Section Molecular Biology)

Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML

edited by

Albrecht Reichle

submission deadline 31 Jul 2026 | Viewed by 142 | Submission Open

Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine; decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress

edited by

Maria Giulia Lionetto

and

Maria Elena Giordano

submission deadline 31 Jul 2026 | Viewed by 103 | Submission Open

Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways

(This special issue belongs to the Section Molecular Toxicology)

Selected Papers from the HSG-2025 Conference

edited by

Marsel Kabilov

submission deadline 31 Jul 2026 | Viewed by 96 | Submission Open

Keywords: metagenomics; genomics; metabarcoding; next-generation sequencing; transcriptomics; translatomics; NGS data analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Computer-Aided Drug Discovery: Insights from Computational Chemistry and Cheminformatics

edited by

Ismail Hdoufane

and

Mehdi Oubahmane

submission deadline 31 Jul 2026 | Viewed by 86 | Submission Open

Keywords: computer-aided drug design (CADD); computational chemistry; cheminformatics; molecular dynamics simulations; molecular modeling; QSAR modeling; virtual screening; artificial intelligence in drug discovery

(This special issue belongs to the Section Molecular Informatics)

Bioactive Natural Products: From Molecular Mechanisms to Biological Function

edited by

Noureddine El Aouad

submission deadline 31 Jul 2026 | Viewed by 75 | Submission Open

Keywords: natural products; molecular mechanism; biological activities; drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of GPCR Signaling

edited by

Kyeong-Man Kim

submission deadline 31 Jul 2026 | Viewed by 54 | Submission Open

Keywords: biased signaling; allosteric modulation; receptor conformations; spatiotemporal signaling; allosteric modulation; receptor trafficking; signaling networks; structure-based drug design

(This special issue belongs to the Section Biochemistry)

Molecular Pathogenesis and Novel Therapeutic Targets in Oncologic Cardiotoxicity

edited by

Marco Tana

submission deadline 31 Jul 2026 | Viewed by 52 | Submission Open

Keywords: cardiotoxicity; CTRCD; heart failure; HFrEF; HFpEF

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Glomerular Diseases, 2nd Edition

edited by

Gian Marco Ghiggeri

submission deadline 31 Jul 2026 | Viewed by 51 | Submission Open

Keywords: glomerulonephritis; proteinuria; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Eukaryotic Mitogenomes: Key Insights

edited by

Yuri Kartavtsev

submission deadline 31 Jul 2026 | Viewed by 51 | Submission Open

Keywords: eukaria; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations

(This special issue belongs to the Section Molecular Biology)

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition

edited by

Michael C. Levin

submission deadline 31 Jul 2026 | Viewed by 44 | Submission Open

Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis

(This special issue belongs to the Section Molecular Immunology)

Molecular Characterization and Utilization of Plant Genetic Resources

edited by

Roel Rabara

submission deadline 31 Jul 2026 | Viewed by 43 | Submission Open

Keywords: molecular markers; genetic resources; genomics; transcriptomics; molecular characterization; genetic diversity; transcriptomics; bioinformatics; germplasm enhancement; epigenetics

(This special issue belongs to the Section Molecular Plant Sciences)

Green Gold: Microalgae as a Sustainable Source of Nutrients and Bioactive Compounds

edited by

Blanca Hernández-Ledesma

and Pilar Gómez-Cortés

submission deadline 31 Jul 2026 | Viewed by 42 | Submission Open

Keywords: microalgae; sustainable nutrition; bioactive compounds; functional foods; nutraceuticals; alternative proteins; phycochemistry; circular bioeconomy; biorefinery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Computational and Multi-Omics Bioinformatics in Cancer Biology and Therapy Response

edited by

Prasoon Agarwal

submission deadline 31 Jul 2026 | Viewed by 37 | Submission Open

Keywords: cancer bioinformatics; multi‑omics integration; precision oncology; tumor heterogeneity; tumor microenvironment; therapy response; machine learning; deep learning; AI‑driven analysis; single‑cell multi‑omics; spatial omics; immunotherapy; tumor– immune interactions; network biology; pathway analysis; biomarker discovery; clinical outcome prediction; translational bioinformatics

(This special issue belongs to the Section Molecular Informatics)

Recent Advances in Neuroprotective Drug Development and Therapeutic Applications

edited by Jolanta Helena Kotlińska

submission deadline 31 Jul 2026 | Viewed by 31 | Submission Open

Keywords: neuropharmacology; neuroprotective drugs; dopaminergic and glutamatergic signaling; endocannabinoid system; neurodevelopmental and stress-related disorders

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Nutrients and Oxidative Stress

edited by

Duško P. Blagojević

submission deadline 31 Jul 2026 | Viewed by 31 | Submission Open

Keywords: oxidative stress; redox regulation; reactive oxygen species; antioxidants; nutrients; functional food

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights in Neuro-Ophthalmology

edited by

Toshiyuki Oshitari

submission deadline 31 Jul 2026 | Viewed by 27 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on the Antioxidant, Anti-Inflammatory, and Antibacterial Activities of Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 31 Jul 2026 | Viewed by 19 | Submission Open

Keywords: natural bioactive compounds; antioxidant mechanisms; anti-inflammatory pathways; antibacterial activity; agro-industrial byproducts; molecular docking; structure– activity relationship (SAR); omics technologies; drug delivery systems; nanobiotechnology; bioavailability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Issues in DNA Damage and DNA Repair

edited by Silvina B. Nadin

submission deadline 31 Jul 2026 | Viewed by 10 | Submission Open

Keywords: genome instability; DNA damage response; DNA repair mechanisms; cancer; therapeutic targets; preclinical studies; translational studies; DNA repair and immune system; PARP inhibitors; BRCA1/2

(This special issue belongs to the Section Molecular Biology)

Genetic and Molecular Strategies to Soybean Improvement

edited by

Junming Sun

submission deadline 31 Jul 2026 | Viewed by 3 | Submission Open

Keywords: soybean; genome editing; CRISPR/Cas9; quantitative trait loci (QTL); marker-assisted selection; functional genomics; molecular breeding; crop improvement; gene expression; genetics and breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 1 Aug 2026 | Viewed by 100 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

New Advances in Animal Reproduction

edited by Valdevane Rocha Araújo

submission deadline 10 Aug 2026 | Viewed by 85 | Submission Open

Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds

(This special issue belongs to the Section Molecular Biology)

Molecular Pathogenesis and Treatments of Pediatric Leukemias

edited by

Joanna Zawitkowska

submission deadline 10 Aug 2026 | Viewed by 36 | Submission Open

Keywords: monoclonal antibodies; tyrosine kinase inhibitors; CAR-T; chemotherapy; drug induced toxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Development and Hormonal Signaling

edited by

Naoufal Lakhssassi

submission deadline 20 Aug 2026 | 6 articles | Viewed by 14146 | Submission Open

Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance

(This special issue belongs to the Section Molecular Plant Sciences)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 20 Aug 2026 | 4 articles | Viewed by 5318 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Aug 2026 | 2 articles | Viewed by 5132 | Submission Open

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3051-3100 on page 62 of 64.

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