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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Pathways Involved in Age-Related Musculoskeletal Disorders

edited by

Abhishek Chandra

and Neha Dole

submission deadline 31 Mar 2026 | Viewed by 212 | Submission Open

Keywords: musculoskeletal disorders; cellular senescence; aging; genetic mutations; oxidative stress; mitochondrial dysfunction; bone homeostasis

(This special issue belongs to the Section Molecular Biology)

Advances in HIV Research: Molecular Basis and Potential Therapies

edited by

Sharilyn Almodovar

submission deadline 31 Mar 2026 | Viewed by 190 | Submission Open

Keywords: human immunodeficiency virus; HIV prevention; HIV therapeutics; HIV vaccines; antiretroviral therapies; long-acting ART; HIV genetic therapy; HIV animal models; HIV in vitro models; viral reservoirs; HIV latency; HIV persistence; HIV evolution; HIV quasispecies; HIV proteins; HIV cure; HIV immunopathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Squamous Cell Carcinoma: From Pathogenesis to Targeted Therapy

edited by

Giuseppina Campisi

and

Vito Carlo Alberto Caponio

submission deadline 31 Mar 2026 | Viewed by 167 | Submission Open

Keywords: oral cancer; oral potentially malignant disorders; omics; oral squamous cell carcinoma; leukoplakia; biomarkers; tumor microenvironment; immunotherapy; target therapy; HPV; multidisciplinary team

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biomarkers for Assessing Marine Ecosystem Health

edited by

Maria Costantini

Valerio Zupo

and

Roberta Esposito

submission deadline 31 Mar 2026 | Viewed by 158 | Submission Open

Keywords: biodiversity; biomarkers; biomonitoring; marine organisms; pollution; metals; microplastics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond the Resolution Revolution: The Next Era of Cryo-EM and Structural Biology

edited by

Gaya P. Yadav

submission deadline 31 Mar 2026 | Viewed by 148 | Submission Open

Keywords: cryo-electron microscopy (cryo-EM); membrane protein structure; cryo-tomography and 3D reconstruction; advances in sample vitrification; structure-guided drug discovery; lipid– protein dynamics; innovations in cryo-EM methodology

(This special issue belongs to the Section Molecular Biology)

Recent Progress and Perspectives in Natural Products

edited by

Hanae Naceiri Mrabti

and

Naoufal El Hachlafi

submission deadline 31 Mar 2026 | Viewed by 140 | Submission Open

Keywords: natural products; bioactive compounds; pharmacology; nutrition; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Metal Complexes: From Structural Characterization to Pharmacological Effects

edited by

Valentina Uivarosi

submission deadline 31 Mar 2026 | Viewed by 134 | Submission Open

Keywords: metal complexes; structural analysis; medicinal inorganic chemistry; metal– biomolecule interactions; biological activity; anticancer agents; antimicrobial activity; antiviruses activity; antidiabetic activity; pharmacological effects; therapeutic applications

(This special issue belongs to the Section Biochemistry)

Recent Advances in Dementia with Lewy Bodies (DLB) and Alzheimer’s Disease (AD)

edited by Yuan-Han Yang

submission deadline 31 Mar 2026 | Viewed by 131 | Submission Open

Keywords: dementia with Lewy bodies; Alzheimer's disease; amyloid; tau; alpha-synuclein

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapy for Breast and Gynecological Cancer

edited by Moira Ragazzi and Elisa Gasparini

submission deadline 31 Mar 2026 | Viewed by 130 | Submission Open

Keywords: breast cancer; gynecological cancer; target therapy; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress and Glutathione Content in Liver Diseases: Innovative Signaling Pathways and Molecular Mechanisms

edited by

Mariapia Vairetti

Andrea Ferrigno

and

Giuseppe Colucci

submission deadline 31 Mar 2026 | Viewed by 125 | Submission Open

Keywords: oxidative stress; glutathione; MASLD; MASH; hepatic infections

(This special issue belongs to the Section Molecular Biology)

Exploring Natural Products for Cancer

edited by Ana Carolina Gonçalves

submission deadline 31 Mar 2026 | Viewed by 114 | Submission Open

Keywords: natural products; plant-derived compounds; phenolic compounds; pharmacodynamics; pharma-cokinetics; antioxidant capacities; cancer; oxidative stress-related disorders; in vivo assays; in vitro assays; clinical assays; mechanisms of differentiation; tissue homeostasis

(This special issue belongs to the Section Molecular Oncology)

New Insights into Neuroproteins

edited by

Fabrizio Michetti

submission deadline 31 Mar 2026 | Viewed by 109 | Submission Open

Keywords: neuroproteins; S100B; glial fibrillary acidic protein; neuron-specific enolase; alpha-synuclein; amyloid proteins

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Rheumatic Diseases and Rheumatoid Arthritis

edited by

Ilaria Mormile

submission deadline 31 Mar 2026 | Viewed by 109 | Submission Open

Keywords: rheumatoid arthritis; systemic lupus erythematous; systemic sclerosis; Sjö gren’ s syndrome; psoriatic arthritis; rare autoimmune rheumatic diseases; vasculitis; biological therapies

(This special issue belongs to the Section Molecular Immunology)

Pain Pathways Rewired: Moving past Peripheral Ion Channel Strategies

edited by

Ari-Pekka Koivisto

submission deadline 31 Mar 2026 | Viewed by 107 | Submission Open

Keywords: central mechanism of action; central terminal; chronic pain; multichannel block; NaV channel; non-neuronal cell; novel analgesics; pain transduction; subthreshold membrane potential oscillation; TRP channel

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Nutritional Neuroscience: Diet, Microbiota, and Brain Function

edited by

Ana Isabel Beltrán-Velasco

submission deadline 31 Mar 2026 | Viewed by 103 | Submission Open

Keywords: nutritional neuroscience; gut– brain axis; diet; microbiota; molecular mechanisms; neuroinflammation; cognitive function; neurodegeneration; omics; biomarkers

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insight into Non-Coding RNAs (ncRNAs) in Human Research

edited by

Brian D. Adams

submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open

Keywords: lncRNA; therapy; cancer; SLNCR; tumor suppressor; SINE; estrogen; ERRL01

(This special issue belongs to the Section Molecular Biology)

Advanced Biomaterials for Neural Regeneration and Axogenesis: From Cellular Support to Functional Recovery

edited by Noela Rodríguez-Losada

submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open

Keywords: neural regeneration; axogenesis; neurorepair; neuroprotection; biocompatible materials; extracellular matrix mimetics; graphene-based scaffolds; conductive polymers; hybrid hydrogels; carbon nanomaterials; neuroengineering

(This special issue belongs to the Section Molecular Neurobiology)

Genetic and Molecular Basis of Diseases in Preterm Infants

edited by Dawid Szpecht

submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open

Keywords: genetic factors; prematurity complications; gene variants; inflammatory response; preterm infants

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cytomegalovirus: An Unresolved Puzzle in Transplantation

edited by

Eleonora Forte

, Zheng Zhang and Lorenzo Gallon

submission deadline 31 Mar 2026 | Viewed by 98 | Submission Open

Keywords: cytomegalovirus; latency; reactivation; transplantation; virus-host interaction; immune evasion; host immune response; omics approaches; high-throughput technologies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights into Amyotrophic Lateral Sclerosis

edited by

Viviana Greco

submission deadline 31 Mar 2026 | Viewed by 97 | Submission Open

Keywords: amyotrophic lateral sclerosis; proteomics; protein aggregation; mitochondria; neurodegeneration; RNA metabolism; oxidative stress; neuroinflammation; systems biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Skeletal Muscle Aging: Mechanisms, Biomarkers, and Interventions

edited by

Ida Cariati

submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open

Keywords: skeletal muscle aging; sarcopenia; muscle metabolism; mitochondrial dysfunction; inflammation; exercise adaptation; muscle adaptation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic–Epigenetic Interplay in Healthy and Diseases

edited by

Ana Paula De Souza

submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open

Keywords: epigenetics; metabolism; TCA cycle; one-carbon cycle; aging; longevity; cancer; metabolic syndrome; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Drug Discovery: Emerging Radiotracers and Small Molecule Inhibitors for Cancer and Neurological Disorders

edited by Ramya Tokala

submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open

Keywords: radiotracers; cytotoxic agents; drug discovery; molecular imaging; cancer therapy; neurological disorders; radiochemistry; medicinal chemistry; theranostics; drug development; molecular diagnostics

(This special issue belongs to the Section Molecular Pharmacology)

T Cell Receptor (TCR) Signaling at the Crossroads of Immunity, Tolerance, and Disease

edited by Amar Singh

submission deadline 31 Mar 2026 | Viewed by 92 | Submission Open

Keywords: T cell receptor (TCR) signaling; immune tolerance; effector T cell differentiation; regulatory T cells (Tregs; Tr1); T cell heterogeneity; metabolic reprogramming; T cell memory and exhaustion; TCR repertoire analysis; autoimmunity and inflammation; TCR-based immunotherapy; CAR-T cells

(This special issue belongs to the Section Molecular Immunology)

Metabolic Dysfunction and Cardiovascular Disease

edited by

Carmine Savoia

submission deadline 31 Mar 2026 | Viewed by 91 | Submission Open

Keywords: metabolic dysfunction; cardiovascular disease; inflammation; endothelial dysfunction; oxidative stress; biomarkers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Amyloid-β: An Antimicrobial Defense Peptide

edited by

Anna Lia Asti

submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open

Keywords: amyloid (Aß ); aggregation prone regions (ARPs); lipopolysaccharide (LPS); amphipathic molecules; LL-37 peptide; neurodegeneration; aggregation inhibition; Alzheimer's disease (AD)

(This special issue belongs to the Section Molecular Biology)

Advances in Plant Molecular Breeding and Molecular Diagnostics

edited by

Jiří Sedlák

submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open

Keywords: plant molecular breeding; molecular diagnostics; pathogen detection; disease symptomatology; genetic resources; genetic diversity; phenology; genotype– phenotype integration; genome editing; omics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Bacteria: 2nd Edition

edited by

Giovanni Stelitano

submission deadline 31 Mar 2026 | Viewed by 87 | Submission Open

Keywords: bacteria; molecular biology; infections; antimicrobials; bacterial enzymes; bioremediation; enzyme evolution and adaptation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights into Allergic Asthma

edited by

Luisa Ricciardi

submission deadline 31 Mar 2026 | Viewed by 87 | Submission Open

Keywords: allergic asthma; molecular mechanisms; allergen exposure; T2 inflammation; inhaler treatment; biological treatment

(This special issue belongs to the Section Molecular Immunology)

Advances in Understanding the Molecular Basis of Antimicrobial Properties in Natural Products, Functional Additives, and Food-Derived Compounds

edited by

Aleksandra Maria Kocot

submission deadline 31 Mar 2026 | Viewed by 85 | Submission Open

Keywords: natural antibacterial substances; antibacterial activity; bacterial metabolites; functional additives; antibacterial peptides

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of RNA Interactions and Biomarker Discovery for Human Diseases

edited by

Lei Wang

submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open

Keywords: biomarker discovery; RNA interactions; RNA– disease associations; drug– RNA interactions; therapeutic targets

(This special issue belongs to the Section Molecular Informatics)

Molecular Insights and Novel Therapeutics in Chronic Kidney Disease

edited by

Marijn Speeckaert

submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open

Keywords: chronic kidney disease (CKD); molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bridging the Omics of Protein Landscape of Aging and Disease: New Insights and Opportunities

edited by

Fátima Milhano Santos

submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open

Keywords: age-related disease; aging; biomarkers; chronic diseases; neurodegenerative diseases; ocular diseases; proteomics; kidney diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Advances in Ear Diseases

edited by

András Molnár

submission deadline 31 Mar 2026 | Viewed by 82 | Submission Open

Keywords: vertigo; hearing loss; tinnitus; otosclerosis; Mé niè re’ s disease; middle ear; inner ear; drug therapies; laboratory findings; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles of Erythrocytes in Human Health and Disease: 4th Edition

edited by

Francesco Misiti

submission deadline 31 Mar 2026 | Viewed by 82 | Submission Open

Keywords: erythrocytes; red blood cells; red blood functions; vascular function; blood bank storage

(This special issue belongs to the Section Molecular Biology)

T Regulatory and NKT Cells as Prognostic Biomarkers in Inflammatory Disorders and Cancers

edited by

Elena Matei

submission deadline 31 Mar 2026 | Viewed by 82 | Submission Open

Keywords: immune response; Tregs; NKT; regulation pathways; prognostic biomarkers

(This special issue belongs to the Section Molecular Immunology)

Allergic Reactions and Immune Factors

edited by

Liborija Lugovic-Mihic

submission deadline 31 Mar 2026 | Viewed by 82 | Submission Open

Keywords: allergic reactions; immunity; immunological factors; hypersensitivity; antibody; cytokine; immune response; etiology; pathogenesis; clinical manifestations; diagnostic; therapy

(This special issue belongs to the Section Molecular Immunology)

PPAR Update: Molecular Mechanisms and Therapeutic Perspectives

edited by

Naoki Tanaka

submission deadline 31 Mar 2026 | Viewed by 81 | Submission Open

Keywords: PPAR; PPARα ; SPPARMα ; pemafibrate; lipid metabolism; inflammation; fibrosis; nuclear receptor; translational research; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

AI-Driven and Physics-Based Modeling in Molecular Engineering Systems

edited by

Bilal Lamrani

submission deadline 31 Mar 2026 | Viewed by 81 | Submission Open

Keywords: molecular engineering systems; AI model; physics

(This special issue belongs to the Section Molecular Informatics)

The GPR81 Receptor: Lactate as Signaling Molecule in Health and Disease

edited by

Tania Fiaschi

submission deadline 31 Mar 2026 | Viewed by 81 | Submission Open

Keywords: lactate; GPR81 receptor; signaling cascade

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Endocrine and Metabolic Diseases

edited by

Ferenc Sztanek

submission deadline 31 Mar 2026 | Viewed by 80 | Submission Open

Keywords: systems biology; metabolomics; fluxomics; organoid models; epigenetic regulation; precision medicine; endocrine–metabolic crosstalk

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Research in Crops: From Physiology to Breeding

edited by

Guang Chen

and Edyta Zdunek-Zastocka

submission deadline 31 Mar 2026 | Viewed by 78 | Submission Open

Keywords: crops; stress; cultivation measures; molecular mechanisms; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Neural Stem Cells as Tools for Therapies: Challenges and Future Perspectives

edited by

Daniele Bottai

submission deadline 31 Mar 2026 | Viewed by 78 | Submission Open

Keywords: spinal cord injury; spinal muscular atrophy; amyotrophic lateral sclerosis; neurological diseases; neural stem cell differentiation; cellular models; transplantation; trophic factor release

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Non-Coding RNAs, Alarmins, Protein Dynamics, and Therapeutic Targets in Disease

edited by

Alessandra Magenta

and

Elena Dellambra

submission deadline 31 Mar 2026 | Viewed by 77 | Submission Open

Keywords: non-coding RNAs; alarmins; protein dynamics; therapeutic intervention; inflammatory; cancer; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Beyond Drivers and Suppressors: Investigating Upstream Regulators of Cell Death

edited by Damian Kołat

submission deadline 31 Mar 2026 | Viewed by 76 | Submission Open

Keywords: cell death; driver genes; suppressor genes; upstream regulators; gene expression; in silico; in vitro; in vivo

(This special issue belongs to the Section Molecular Biology)

Rational Design and Advanced Synthesis of Nanomaterials for Electrocatalysis

edited by

Marco Aurélio Suller Garcia

submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open

Keywords: nanocatalysts; supercapacitors; (electro)oxidation of alcohols; oxygen reduction reaction; hydrogenation reactions; hydroformylation; electrochemical sensors

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Therapeutic Strategies for Oral Mucosal Diseases: From Radiotherapy-Induced Damage to Other Pathologies

edited by

Fernanda Gonçalves Salum

submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open

Keywords: oral mucosal diseases; drug-induced oral lesions; radiotherapy- and chemotherapy-induced oral disorders; targeted therapy- and immunotherapy-induced stomatitis; oxidative stress and inflammation; oral microbiome and immunity; nanomedicine and biomaterials; photobiomodulation and photodynamic therapy; oral potentially malignant disorders; oral oncology; immune modulation; tissue regeneration and repair; translational research; investigational therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Antimicrobial Resistance

edited by

Maria Teresa Mascellino

submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open

Keywords: drug resistance; microorganisms; molecular mechanisms; mobile genetic elements; CRISPR/Cas9; nucleic acid hybriditation; probes; LAMP

(This special issue belongs to the Section Molecular Microbiology)

Microbiostatic/Microbicidal Agents and Materials

edited by

Adam Feliks Junka

submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open

Keywords: antimicrobial resistance (AMR); biofilm; antimicrobial peptides; plant-derived compounds; synergistic therapies

(This special issue belongs to the Section Molecular Microbiology)

Plant Responses to Environmental Stresses: Physiological and Molecular Mechanisms

edited by

Viviana Maresca

and

Alessia Postiglione

submission deadline 31 Mar 2026 | Viewed by 74 | Submission Open

Keywords: plant stress; abiotic stress; biotic stress; oxidative stress; antioxidant enzymes; reactive oxygen species (ROS); phytoremediation; biomonitoring; secondary metabolites; molecular mechanisms; omics approaches; bryophytes; heavy metals; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 2501-2550 on page 51 of 70.

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