Molecular Insights into Amyotrophic Lateral Sclerosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 26
Special Issue Editor
Interests: amyotrophic lateral sclerosis; hydrogen sulfide; mitochondrial dysfunction; proteomics; PTMs; redox dysregulation; neurodegeneration; protein aggregation and misfolding; systems biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the progressive degeneration of motor neurons, ultimately leading to paralysis and death. Despite important advances in genetics and neuroscience, the molecular mechanisms underlying ALS remain poorly understood, and effective therapeutic strategies are still urgently needed.Proteome-wide analyses, combined with other omics approaches, are shedding light on dysregulated pathways, protein misfolding and aggregation, defects in proteostasis, mitochondrial dysfunction, and altered RNA metabolism. These studies not only improve our understanding of disease pathogenesis but also hold great promise in the identification of novel biomarkers and therapeutic targets.This Special Issue will showcase original research articles and reviews that provide new molecular insights into ALS, with a particular emphasis on biochemical, proteomic, and integrative omics approaches. We welcome contributions focusing on protein dynamics, cellular metabolism, RNA-binding proteins, neuroinflammation, and experimental therapeutic strategies. By sharing multidisciplinary perspectives, this Special Issue will advance our molecular understanding of ALS and promote the development of innovative diagnostic and therapeutic tools.
Dr. Viviana Greco
Guest Editor
Manuscript Submission Information
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Keywords
- amyotrophic lateral sclerosis
- proteomics
- protein aggregation
- mitochondria
- neurodegeneration
- RNA metabolism
- oxidative stress
- neuroinflammation
- systems biology
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