Molecular Insights into Amyotrophic Lateral Sclerosis

Dear Colleagues, 

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the progressive degeneration of motor neurons, ultimately leading to paralysis and death. Despite important advances in genetics and neuroscience, the molecular mechanisms underlying ALS remain poorly understood, and effective therapeutic strategies are still urgently needed.Proteome-wide analyses, combined with other omics approaches, are shedding light on dysregulated pathways, protein misfolding and aggregation, defects in proteostasis, mitochondrial dysfunction, and altered RNA metabolism. These studies not only improve our understanding of disease pathogenesis but also hold great promise in the identification of novel biomarkers and therapeutic targets.This Special Issue will showcase original research articles and reviews that provide new molecular insights into ALS, with a particular emphasis on biochemical, proteomic, and integrative omics approaches. We welcome contributions focusing on protein dynamics, cellular metabolism, RNA-binding proteins, neuroinflammation, and experimental therapeutic strategies. By sharing multidisciplinary perspectives, this Special Issue will advance our molecular understanding of ALS and promote the development of innovative diagnostic and therapeutic tools.

Dr. Viviana Greco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.