Metabolic–Epigenetic Interplay in Healthy and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 19
Special Issue Editor
Special Issue Information
Dear Colleagues,
Advances in molecular biology have contributed to the advancement of the understanding of the dynamic crosstalk between cellular metabolism and epigenetic regulation. Metabolites such as acetyl-CoA, NAD+, S-adenosylmethionine, and α-ketoglutarate serve not only as essential intermediates but also as substrates and cofactors for chromatin-modifying enzymes, directly linking metabolic states to gene expression profiles. This metabolic–epigenetic axis plays a pivotal role in maintaining cellular homeostasis and orchestrating adaptive responses to environmental cues. The dysregulation of this interplay has emerged as a critical driver in the pathogenesis of complex diseases, including cancer, neurodegeneration, metabolic syndromes, and aging-related disorders. This Special Issue of the International Journal of Molecular Sciences aims to gather original research and comprehensive reviews that explore the bidirectional relationship between metabolism and epigenetics in both physiological and pathological contexts. We welcome contributions that elucidate novel molecular mechanisms, highlight therapeutic targets, or present integrative omics approaches that expand our understanding of this intricate interface. Through this collection, we seek to advance the field toward innovative strategies for diagnosis, prevention, and treatment based on the metabolic–epigenetic interplay.
Prof. Dr. Ana Paula De Souza
Guest Editor
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Keywords
- epigenetics
- metabolism
- TCA cycle
- one-carbon cycle
- aging
- longevity
- cancer
- metabolic syndrome
- neurodegeneration
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