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Recent Advances in Dementia with Lewy Bodies (DLB) and Alzheimer’s Disease (AD)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 1105

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Kaohsiung Medical University Gangshan Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Interests: amyloids; Alzheimer’s disease
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Special Issue Information

Dear Colleagues,

We are pleased to announce a call for papers in a Special Issue entitled “Recent Advances in Dementia with Lewy Bodies (DLB) and Alzheimer's Disease (AD)”. The Issue aims to create a comprehensive forum for neurologists, researchers, geriatricians, and healthcare professionals to disseminate cutting-edge findings. We welcome submissions on a broad range of topics, including but not limited to, the following:

  • Novel disease-modifying therapies: Anti-amyloid, anti-tau, and anti-alpha-synuclein approaches; immunotherapies; and targeted small molecules.
  • Symptomatic treatment innovations: Advanced management of cognitive, psychiatric, and motor symptoms.
  • Biomarker-driven treatment: The role of PET, CSF, and blood-based biomarkers in diagnosis, patient selection, and monitoring treatment efficacy and safety.
  • Other molecular mechanisms/pathways: The application of digital health and other technologies to these diseases.

We invite the submission of original research articles, systematic reviews, meta-analyses, and case series that push the boundaries of our understanding and pave the way for the next generation of dementia care.

Prof. Dr. Yuan-Han Yang
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • dementia with Lewy bodies
  • Alzheimer's disease
  • amyloid
  • tau
  • alpha-synuclein

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Published Papers (1 paper)

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9 pages, 419 KB  
Brief Report
Using Plasma Amyloid Beta Oligomer to Screen in Alzheimer’s Disease: A Pilot Study
by Pin-Chieh Hsu, Jia-Ying Yang, Ling-Chun Huang and Yuan-Han Yang
Int. J. Mol. Sci. 2026, 27(2), 846; https://doi.org/10.3390/ijms27020846 - 14 Jan 2026
Viewed by 608
Abstract
Previous studies have shown that plasma amyloid-beta oligomers (AβOs), the toxic form of amyloid-beta (Aβ), are a critical issue in the development or worsening of Alzheimer’s disease (AD) and can be regarded as a blood marker for screening in dementia. We examined plasma [...] Read more.
Previous studies have shown that plasma amyloid-beta oligomers (AβOs), the toxic form of amyloid-beta (Aβ), are a critical issue in the development or worsening of Alzheimer’s disease (AD) and can be regarded as a blood marker for screening in dementia. We examined plasma AβOs with their related biomarkers in a case–control study to clarify these issues. A total of 16 patients diagnosed with Alzheimer’s dementia (AD) and 16 cognitively normal controls (NCs) were recruited to compare their plasma biomarkers, AβO, Aβ1-40, and Aβ1-42, also referring to other parameters like APOE ε4 status, Clinical Dementia Rating®-Sum of Boxes (CDR®-SB), and Mini Mental Status Examination (MMSE) scores. In plasma concentrations of Aβ1-40, Aβ1-42, and AβO, the mean concentrations were significantly different between the two groups. There is a significant increase in the concentrations of Aβ1-40 and AβO, while Aβ1-42 is decreased in individuals with AD compared to NC. AβO was statistically associated with the Aβ1-40 and Aβ1-42/Aβ1-40 ratio. Higher plasma concentrations of AβO were significantly associated with AD compared to non-dementia controls. This suggests that AβOs can be potential plasma biomarkers to screen in AD. However, a study recruiting more individuals is necessary to examine the association, if any. Full article
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