Oxidative Stress and Glutathione Content in Liver Diseases: Innovative Signaling Pathways and Molecular Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 March 2026
Special Issue Editors
Interests: liver; NAFLD/NASH; farnesoid X receptor; oxidative stress; metalloproteinases; signal transduction
Special Issues, Collections and Topics in MDPI journals
Interests: liver; ischemia/reperfusion; metabotropic glutamate receptor 5; inflammation; G protein-coupled receptors
Special Issues, Collections and Topics in MDPI journals
Interests: chronic hepatitis; NAFLD-NASH; immunopatholoy; liver fibrosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Liver reactive oxygen species (ROS), products of oxidative stress, contribute to the initiation and progression of acute liver injury as well as the pathogenesis of metabolic chronic liver disease (MASLD and MASH) or hepatic infections (viral hepatitis B or C). Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important thiol reducing agent involved not only in the modulation of redox processes but also in the network governing the choice between survival, necrosis, and apoptosis, as well as in altering the function of signal transduction and transcription factor molecules. The Special Issue, “Oxidative Stress and Glutathione Content in Liver Diseases: Innovative Signaling Pathways and Molecular Mechanisms”, of the International Journal of Molecular Sciences, will include a selection of original research papers and reviews on novel signaling pathways as well as molecular mechanisms by which oxidative stress promotes liver disease. Due to the close relationship existing between GSH content and the pathogenesis of several liver disorders, this Special Issue will also include the potential therapeutic benefits of GSH and GSH-related medication; in addition, an update on the management of liver diseases associated with oxidative stress will be taken into account.
Dr. Mariapia Vairetti
Dr. Andrea Ferrigno
Dr. Giuseppe Colucci
Guest Editors
Manuscript Submission Information
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Keywords
- oxidative stress
- glutathione
- MASLD
- MASH
- hepatic infections
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