The GPR81 Receptor: Lactate as Signaling Molecule in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 120
Special Issue Editor
Interests: skeletal muscle; cancer cachexia; adipokine adiponectin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
GPR81 is a seven-transmembrane G-protein-coupled receptor that acts as a lactate sensor. The binding of lactate to GPR81 triggers a signaling cascade that leads to a decrease in the second messenger cyclic AMP. It is well established that lactate has a pleiotropic role, functioning both as metabolite and as a signaling molecule under healthy and pathological conditions. Growing evidence indicates that lactate plays a crucial role in activating the signaling cascade mediated by GPR81, thereby influencing multiple cellular effects. This Special Issue aims to present recent advances in the lactate-induced GPR81 signaling cascade and to explore potential new strategies for GPR81 inhibition.
Dr. Tania Fiaschi
Guest Editor
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Keywords
- lactate
- GPR81 receptor
- signaling cascade
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