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Advances in Understanding the Molecular Basis of Antimicrobial Properties in Natural Products, Functional Additives, and Food-Derived Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 September 2026 | Viewed by 1336

Editor


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Guest Editor
Department of Microbiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland
Interests: food safety; food protection; biofilm; antimicrobial; probiotic; functional food; lactic acid bacteria; LAB
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, in the scientific community has been reviving its interest in natural antibacterial substances. Topics of interest include plant extracts, essential oils, bacterial metabolites, functional (food) additives, and food components such as antibacterial peptides. The antibacterial effects of many natural substances are widely known, but increasingly refined research methods and techniques allow us to better understand the mechanisms of their action on bacterial cells.

In this Special Issue, we want to explore the antibacterial effects of natural substances. We are interested in the effectiveness of these substances, their targeting and spectrum of action, as well as the molecular mechanism of their action on diverse groups of microorganisms. We encourage the publication of short communications and scientific and review articles.

Research areas may include (but are not limited to) the following:

  • Antibacterial activity of natural substances—target and spectrum of action
  • Search for and identification of new natural compounds with antibacterial activity
  • New insights into the mechanism of action of natural compounds and functional additives on bacterial cells
  • Innovative methods for testing the antibacterial properties of natural and food-derived substances 

Dr. Aleksandra Maria Kocot
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural antibacterial substances
  • antibacterial activity
  • bacterial metabolites
  • functional additives
  • antibacterial peptides

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Published Papers (2 papers)

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Research

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12 pages, 1629 KB  
Article
Sustainable Synthesis of Calcium Propionate from Cockle Shell Biowaste for Food Additive Production
by Chaowared Seangarun, Banjong Boonchom, Somkiat Seesanong, Wimonmat Boonmee, Sirichet Punthipayanon, Nongnuch Laohavisuti and Pesak Rungrojchaipon
Int. J. Mol. Sci. 2026, 27(11), 4955; https://doi.org/10.3390/ijms27114955 - 29 May 2026
Viewed by 344
Abstract
Calcium propionate (Ca(CH3CH2COO)2) was successfully synthesized from cockle shell biowaste through a reaction with propionic acid at concentrations of 80%, 90%, and 99%, valorizing seafood processing biowaste as a renewable calcium source in support of circular economy [...] Read more.
Calcium propionate (Ca(CH3CH2COO)2) was successfully synthesized from cockle shell biowaste through a reaction with propionic acid at concentrations of 80%, 90%, and 99%, valorizing seafood processing biowaste as a renewable calcium source in support of circular economy principles. The synthesis was conducted at ambient temperature with a fixed CaCO3: propionic acid molar ratio of 1:2, enabling rapid reaction completion without external heating or complex purification steps. The prepared samples were characterized by FTIR, XRD, TGA, and SEM techniques, which confirmed the formation of calcium propionate monohydrate (Ca(CH3CH2COO)2·H2O), while XRF confirmed more than 97 wt% CaO across all samples with non-toxic impurities corresponding to compositional requirements for food additive calcium propionate (E282). The sample prepared using 80% propionic acid exhibited the highest yield (90.24%) and soluble percentage (98.23%). The proposed approach demonstrates an effective valorization of cockle shell waste into a food additive, calcium propionate, offering advantages in terms of sustainability, cost efficiency, and scalability, and highlighting its strong potential for industrial food additive production within a circular economy framework. Full article
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Review

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28 pages, 1870 KB  
Review
Medicinal Plants: A Promising Therapeutic Approach for Addressing Antimicrobial Resistance
by Huanxin Zhou, Jinkang Du, Meiyan Jia, Yine Li and Kaiyun Zheng
Int. J. Mol. Sci. 2026, 27(11), 4804; https://doi.org/10.3390/ijms27114804 - 26 May 2026
Viewed by 670
Abstract
Antimicrobial resistance (AMR) is a critical global public health crisis that is being exacerbated by widespread misuse of antibiotics and rapid bacterial adaptation. The progressive decrease in antibiotic efficacy is also compounded by a stagnating drug-discovery pipeline and underscores the urgent need for [...] Read more.
Antimicrobial resistance (AMR) is a critical global public health crisis that is being exacerbated by widespread misuse of antibiotics and rapid bacterial adaptation. The progressive decrease in antibiotic efficacy is also compounded by a stagnating drug-discovery pipeline and underscores the urgent need for innovative and sustainable antimicrobial strategies. This review systematically delineates the core molecular mechanisms driving bacterial resistance, including enzymatic drug inactivation, target modification, reduced membrane permeability, and multidrug efflux pump overexpression. Furthermore, the potential of (flavonoids, alkaloids, and phenolics) as structurally diverse plant-derived compounds with multi-target activity is comprehensively assessed. The features of multi-target activity make them promising dual-function agents that may be capable of both direct antimicrobial action and resistance modulation. These natural products have distinct mechanisms from conventional antibiotics, low propensity for resistance, and versatile bioactivity as biofilm disruptors, enzyme inhibitors, and efflux pump blockers. Numerous phytochemicals exhibit potent synergistic effects with available antibiotics by effectively resensitizing resistant pathogens and extending the clinical utility of current antimicrobials. By integrating mechanistic understanding with translational potential, this review discusses phytochemicals as a sustainable resource for developing next-generation antimicrobial strategies as a complementary approach to revitalize therapeutic pipelines and combat multidrug-resistant infections. Full article
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