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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multi-Omics and Computational Simulation Approaches: Unraveling Novel Antibacterial Mechanisms of Natural Products
edited by Lili Li
submission deadline 30 Nov 2026 | Viewed by 123 | Submission Open
Keywords: natural products; antibacterial mechanism; anti-biofilm; multi-omics; computational simulation; drug-resistant pathogens
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Leveraging Novel Insights from Basic Science to Improve Hepatocellular Carcinoma Management in the Era of Precision Medicine
edited by
submission deadline 30 Nov 2026 | Viewed by 119 | Submission Open
Keywords: hepatocellular carcinoma; tumor microenvironment; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Advances in Viper Envenomation: From Molecular Mechanisms to Treatment
edited by
submission deadline 30 Nov 2026 | Viewed by 116 | Submission Open
Keywords: snake envenomation; viper envenomation; antiviper serum; Europe; guidelines
(This special issue belongs to the Section Molecular Toxicology)
Molecular Biology and Therapeutic Applications of Medicinal Plants
edited by Gothai Sivapragasam and Nanthiney Ragavan
submission deadline 30 Nov 2026 | Viewed by 116 | Submission Open
Keywords: medicinal plants; molecular biology; phytochemicals; wound healing; oxidative stress; inflammation; molecular pharmacology; regenerative medicine; bioactive compounds
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Design, Stabilization, and Controlled Delivery of Probiotics and Bioactive Compounds
edited by Chuang Zhang
submission deadline 30 Nov 2026 | Viewed by 112 | Submission Open
Keywords: probiotics; bioactive compounds; functional foods; microencapsulation; controlled delivery; food biopolymers; molecular interactions; bioavailability; gut microbiota; powder-based delivery systems
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Mesenchymal Stromal Cells Within the Tissue Microenvironment: Translational Research and Therapeutic Perspectives
edited by Francesco Agostini
submission deadline 30 Nov 2026 | Viewed by 72 | Submission Open
Keywords: mesenchymal stem cells; microenvironment; stem niche; cancer; drug delivery; good manufacturing practice; cell therapy; medium additive substitutes; microfluidic conditions; homing; migration; gene editing by (non-)viral methods
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Bladder Cancer
edited by
submission deadline 1 Dec 2026 | 1 articles | Viewed by 864 | Submission Open
Keywords: urothelial carcinoma; molecular subtypes; tumor microenvironment (TME); epigenetics; precision medicine; chemoresistance
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Inflammation in Neurodegenerative Diseases
edited by
submission deadline 1 Dec 2026 | Viewed by 198 | Submission Open
Keywords: neuroinflammation; neurodegenerative diseases; molecular pathways; neuronal cell death; mitochondrial dysfunction; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Stem Cells, Biomaterials, and Molecular Therapies in Plastic Surgery submission deadline 5 Dec 2026 | 1 articles | Viewed by 580 | Submission Open
Keywords: stem cells; tissue engineering; biomaterials and bioactive scaffolds; hydrogels; 3D bioprinting; regenerative medicine and surgery; molecular therapies; growth factors; scar modulation; skin repair
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Applications, Theoretical Studies, Nanomedicine and Molecular Docking Studies in Drug Discovery
edited by
submission deadline 10 Dec 2026 | 1 articles | Viewed by 1127 | Submission Open
Keywords: drug discovery; molecular docking; molecular dynamics; QSAR; nanomedicine; nanoparticles; virtual screening; natural products; in vivo validation; ADMET
(This special issue belongs to the Section Molecular Pharmacology)
Bioactivity of Resveratrol and Flavonoids as Antioxidant and Anti-Inflammatory Compounds: Molecular Insights submission deadline 10 Dec 2026 | 1 articles | Viewed by 1006 | Submission Open
Keywords: resveratrol; flavonoids; polyphenols; antioxidant; anti-inflammatory; molecular mechanism; signal transduction; oxidative stress; gene expression; therapeutic agent
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach—2nd Edition submission deadline 15 Dec 2026 | 4 articles | Viewed by 5292 | Submission Open
Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Research on Cancer Treatments: Apoptosis, Autophagy, and Drug Selection
edited by
submission deadline 20 Dec 2026 | 12 articles | Viewed by 23874 | Submission Open
Keywords: autophagy; apoptosis; bioactive natural products; nanoparticles and drug delivery; cancer immunotherapy; in silico and network pharmacology; bioinformatics
(This special issue belongs to the Section Molecular Oncology)
Biocatalysis of Compounds for Pharmaceutical and Biomedical Applications
edited by
submission deadline 20 Dec 2026 | 4 articles | Viewed by 12924 | Submission Open
Keywords: biocatalysis; biomedical application; biotechnology; compounds for pharmacy; compounds for biomedicine; enantiomers; enzyme activity; enzyme engineering; enzyme immobilization; kinetic resolution; pharmaceutical application; supports materials
(This special issue belongs to the Section Molecular Pharmacology)
Cancer Biology and Epigenetic Modifications
edited by
submission deadline 20 Dec 2026 | 3 articles | Viewed by 11047 | Submission Open
Keywords: epigenetics; DNA methylation; epigenetic modifiers; histone acetylation; histone methylation; miRNA; ncRNA; chrmoatin remodelling
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers submission deadline 20 Dec 2026 | 2 articles | Viewed by 10925 | Submission Open
Keywords: gastrointestinal cancers; liquid biopsy; circulating biomarkers; minimal residual disease; early cancer detection; tumor-agnostic assays; molecular diagnostics; precision oncology; predictive biomarkers; translational research
(This special issue belongs to the Section Molecular Oncology)
Research in Alzheimer’s Disease: Advances and Perspectives
edited by
submission deadline 20 Dec 2026 | 7 articles | Viewed by 10886 | Submission Open
Keywords: neuroinflammation; synaptic dysfunction; oxidative stress; neurofibrillary tangles; mitochondrial dysfunction; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Use of Molecular Biology in the Targeted Prevention, Diagnosis and Therapy of Microbial Infections submission deadline 20 Dec 2026 | 1 articles | Viewed by 6698 | Submission Open
Keywords: microbial infections; AMR; molecular biology; One Health; microbiome
(This special issue belongs to the Section Molecular Microbiology)
From Molecules to Cognition: Biomarkers and Neuropsychological Tools in Neurological Disorders
edited by
submission deadline 20 Dec 2026 | 4 articles | Viewed by 5405 | Submission Open
Keywords: biomarkers; neuropsychological assessment; neurological disorders; neuroimaging; cognitive function; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Molecular Research of Animal Genetics and Genomics
edited by Congjiao Sun
submission deadline 20 Dec 2026 | 4 articles | Viewed by 3652 | Submission Open
Keywords: animal genetics; animal genomics; molecular breeding; genetic improvement; molecular evolution; genomic selection; genome-wide association studies (GWAS); CRISPR; multiomics analysis; animal conservation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research on Bacteria: 2nd Edition
edited by
submission deadline 20 Dec 2026 | 3 articles | Viewed by 3307 | Submission Open
Keywords: bacteria; molecular biology; infections; antimicrobials; bacterial enzymes; bioremediation; enzyme evolution and adaptation
(This special issue belongs to the Section Molecular Microbiology)
Influenza Pathogenesis and Vaccine Development
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 2913 | Submission Open
Keywords: avian influenza; influenza virus; influenza surveillance; interspecies transmission; immune response; pandemic preparedness; pathogenesis; One Health; universal vaccines; vaccine development; viral adaptation; viral evolution; zoonotic infections
(This special issue belongs to the Section Molecular Microbiology)
The Role of Fibroblasts in the Regulation of Tissue Inflammation and Repair
edited by Rebeca Illescas Montes
submission deadline 20 Dec 2026 | 1 articles | Viewed by 2632 | Submission Open
Keywords: fibroblast; wound healing; inflammation; tissue repair; immune–stromal crosstalk; extracellular matrix remodeling; myofibroblast; regenerative medicine; exosomes; biomaterials
(This special issue belongs to the Section Molecular Immunology)
Structural Studies of Phosphorus Compounds Today
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 2393 | Submission Open
Keywords: 31P NMR; NMR; organophosphorus compounds; transition-metal complexes with organophosphorus ligands; relativistic effects; solvent effects; quantum chemistry methods for NMR; chemical structure studies; chemistry of organophosphorus compounds
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular and Cellular Neurobiology of Headache and Migraine
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 2242 | Submission Open
Keywords: headache; migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; PACAP; cluster headache
(This special issue belongs to the Section Molecular Neurobiology)
Autoimmune Diseases: A Swing Dance of Immune Cells, 3rd Edition
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1815 | Submission Open
Keywords: autoimmune diseases; antigens/autoantigens; post-translational modifications; antigen processing and presentation; shared epitopes; molecular mimicry; autoantibodies; immune signaling; animal models; therapeutic agents
(This special issue belongs to the Section Molecular Immunology)
Exosomes and Non-Coding RNA Research in Health and Disease—2nd Edition
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1769 | Submission Open
Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Trends of Quantum Mechanics, Computational Chemistry, and Spectroscopy in Physical Chemistry
edited by
submission deadline 20 Dec 2026 | Viewed by 1068 | Submission Open
Keywords: quantum theory; computational chemistry; spectroscopy
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Neurological and Neurodevelopmental Disorders: Models, Drugs and Technologies
edited by Su-Yun Lyu
submission deadline 20 Dec 2026 | 1 articles | Viewed by 874 | Submission Open
Keywords: neurodevelopmental disorders; disease modeling; molecular mechanisms; neurological; precision medicine; individualized therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Breeding and Comprehensive Utilization of Economic Crops
edited by Xia An
submission deadline 20 Dec 2026 | 1 articles | Viewed by 656 | Submission Open
Keywords: jute; kenaf; flax; okra; mustard; roselle; chloroplast genome; transcriptome; gene cloning; gene function verification; molecular mechanism research; biological stress; abiotic stress
(This special issue belongs to the Section Molecular Plant Sciences)
Intelligent Computational Modeling for Molecular Biomarker Discovery, Prognostic Prediction and Molecular Diagnostics
edited by Chunlong Zhang and Yuming Zhao
submission deadline 20 Dec 2026 | 1 articles | Viewed by 383 | Submission Open
Keywords: molecular biomarkers; prognostic modeling; molecular diagnostics; machine learning; multi-omics; precision medicine
(This special issue belongs to the Section Molecular Informatics)
Unraveling Cell–Cell and Cell–Matrix Interactions: Novel Morphological and Molecular Insights
edited by
submission deadline 20 Dec 2026 | Viewed by 354 | Submission Open
Keywords: DGC; sarcoglycans; cell–cell interactions; cell–matrix interactions; morphological analysis; molecular analysis; molecular pathogenesis; translational studies
(This special issue belongs to the Section Molecular Biology)
From Molecular Mechanisms to Patient Related Outcomes: Advances in Spinal Muscular Atrophy Research and Care
edited by
submission deadline 20 Dec 2026 | Viewed by 253 | Submission Open
Keywords: spinal muscular atrophy (SMA); neuromuscular disorders; SMN protein; disease modifiers; molecular pathogenesis; gene therapy; biomarkers; translational research; therapeutic advances
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Plant Transcriptomics
edited by
submission deadline 20 Dec 2026 | Viewed by 152 | Submission Open
Keywords: plant transcriptomics; RNA-sequencing (RNA-seq); Micro-RNA (miRNA); MRNA-miRNA interactions; machine learning in genomics; deep learning for gene expression; gene regulatory networks; convolutional neural networks; transformer models; functional genomics; functional validation; tissue-specific gene expression; stress-responsive transcriptomics; genotype-by-environment transcriptomics; multi-omics integration; AI-assisted breeding; genomic selection; crop resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Innovative Nanomaterials from Functional Molecules
edited by Xiaoming Zhang and
submission deadline 25 Dec 2026 | 6 articles | Viewed by 50058 | Submission Open
Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition
edited by
submission deadline 25 Dec 2026 | 10 articles | Viewed by 37685 | Submission Open
Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Understanding Allergy and Asthma at the Molecular Level
edited by
submission deadline 25 Dec 2026 | 5 articles | Viewed by 20659 | Submission Open
Keywords: allergy; asthma; allergens; allergic asthma; thunderstorm asthma; cell culture; biomarkers; proteomics; metabolomics; lipidomics; genomics; recombinant allergens; recombinant hypoallergens; signalling; inhibitors; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Biological and Molecular Targets in Schizophrenia
edited by Jacopo Sapienza
submission deadline 25 Dec 2026 | 4 articles | Viewed by 16947 | Submission Open
Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research in Hematologic Malignancies
edited by and
submission deadline 25 Dec 2026 | 7 articles | Viewed by 13665 | Submission Open
Keywords: therapeutic targets; leukemogenesis; molecular regulation; cancer stem cells; epigenetics; novel biomarkers; non-coding RNA; DNA methylation; chemotherapy and genetic changes; cancer; hematologic malignancies
(This special issue belongs to the Section Molecular Oncology)
Antitumor Activity of Natural Products submission deadline 25 Dec 2026 | 7 articles | Viewed by 12472 | Submission Open
Keywords: natural compounds and extracts with antitumor activity; studies on molecular mechanisms; signal transduction modulation in tumor cells; immunomodulating activity; mitosis inhibition; cell differentiation; cell death induction (apoptosis/autophagy)
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Therapeutic Targets in Cardiovascular Health and Cardiotoxicity
edited by
submission deadline 25 Dec 2026 | 8 articles | Viewed by 11653 | Submission Open
Keywords: cardiovascular; ischemia, heart failure; arrhythmogenesis; myocardial remodeling; endothelial dysfunction; cardiology; cardio-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 10956 | Submission Open
Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut–liver axis; spleen–liver axis; alcoholic liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights and Discoveries in the Pathogenesis, Diagnosis and Therapy of Neuromuscular Diseases
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 10833 | Submission Open
Keywords: neuromuscular diseases; autophagy; mitochondrial dysfunction; molecular genetics; blood-based biomarkers; antisense oligonucleotides; monoclonal antibodies
(This special issue belongs to the Section Molecular Neurobiology)
Techniques and Strategies in Drug Design and Discovery, 3rd Edition submission deadline 25 Dec 2026 | 3 articles | Viewed by 10603 | Submission Open
Keywords: drug discovery; drug development; target identification; computational drug design; structure-based drug design; ligand-based drug design
(This special issue belongs to the Section Molecular Pharmacology)
Advanced Molecular Diagnostic Approaches for Neurodevelopmental Disorders: Applications and Future Perspectives
edited by and Michele Pinelli
submission deadline 25 Dec 2026 | 6 articles | Viewed by 10416 | Submission Open
Keywords: neurodevelopmental disorders; array CGH; NGS
(This special issue belongs to the Section Molecular Neurobiology)
Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application submission deadline 25 Dec 2026 | 8 articles | Viewed by 10328 | Submission Open
Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 10084 | Submission Open
Keywords: dementia with Lewy bodies; Alzheimer’s disease; dementing disorders in advanced age
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Associated with Exercise for Health and Performance
edited by Ciro José Brito
submission deadline 25 Dec 2026 | 6 articles | Viewed by 9731 | Submission Open
Keywords: exercise science; sports medicine; aging; genetic and exercise; endocrinology; immunology
(This special issue belongs to the Section Molecular Biology)
Advances in Biomathematics, Computational Biology, and Bioengineering submission deadline 25 Dec 2026 | 6 articles | Viewed by 9255 | Submission Open
Keywords: biomathematics; machine learning; artificial intelligence; data science; systems biology; reaction–diffusion systems; nonlinear dynamics; bioreactors; biochemical reaction engineering
(This special issue belongs to the Section Molecular Informatics)
Medical Applications of Polymer Materials
edited by Zhen Zhang
submission deadline 25 Dec 2026 | 4 articles | Viewed by 9058 | Submission Open
Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics
(This special issue belongs to the Section Macromolecules)
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