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Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 81

Special Issue Editor


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Guest Editor
Gastroenterology and Gastrointestinal Endoscopy Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, 20132 Milan, Italy
Interests: gastrointestinal cancers; liquid biopsy; circulating biomarkers; molecular diagnostics; translational research

Special Issue Information

Dear Colleagues,

Gastrointestinal cancers represent a major global health burden, yet they offer unique opportunities for precision oncology through molecular diagnostics and biomarker-driven approaches. Liquid biopsy technologies, in particular, have transformed colorectal cancer care by enabling noninvasive early detection, minimal residual disease monitoring, and prediction of therapeutic response using both tumor-specific and tumor-agnostic methods. However, the full potential of such strategies remains underexplored in other gastrointestinal malignancies. This Special Issue aims to highlight recent molecular advances and novel biomarkers across the spectrum of gastrointestinal oncology. We welcome contributions spanning fundamental discoveries, translational research, and clinical studies that underscore the promise of molecular tools to improve the prevention, diagnosis, and management of these complex diseases.

Dr. Alessandro Mannucci
Guest Editor

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Keywords

  • gastrointestinal cancers
  • liquid biopsy
  • circulating biomarkers
  • minimal residual disease
  • early cancer detection
  • tumor-agnostic assays
  • molecular diagnostics
  • precision oncology
  • predictive biomarkers
  • translational research

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Published Papers (1 paper)

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Review

34 pages, 1145 KiB  
Review
Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers
by Christina Thoda and Maria Touraki
Int. J. Mol. Sci. 2025, 26(16), 7857; https://doi.org/10.3390/ijms26167857 - 14 Aug 2025
Abstract
Gastrointestinal (GI) cancers represent a major global health burden. Among them, colorectal cancer (CRC) is the most common type, followed by esophagus, stomach, liver, and pancreatic cancer. Since disturbance of the gut microbiota has been directly associated with the development of severe health [...] Read more.
Gastrointestinal (GI) cancers represent a major global health burden. Among them, colorectal cancer (CRC) is the most common type, followed by esophagus, stomach, liver, and pancreatic cancer. Since disturbance of the gut microbiota has been directly associated with the development of severe health issues, including cancer, probiotic administration may induce dysbiosis reversion and ameliorate carcinogenesis. Therefore, manipulation of the gut microbiota composition based on probiotic utilization has gradually attained scientific interest as a potent therapeutic modality for GI cancers. This review aims to synthesize the current in vitro and in vivo evidence on probiotics’ effectiveness in GI cancer chemoprevention and treatment. It also provides a classification of the fundamental anticancer features of probiotics, including antiproliferation and cell death induction, anticarcinogenic compound production, reduction in chemotherapy-related toxicity, gut microbiota modulation, intestinal barrier improvement, antioxidant activity, immunomodulatory/anti-inflammatory effects, and carcinogen detoxification. Finally, it underscores the future perspectives and challenges of probiotic administration to individuals. In this regard, it emphasizes the exploitation of advanced encapsulation techniques and the development of novel genetically engineered probiotics and next-generation probiotics as feasible ways to improve their bioavailability, ensure their targeted delivery, and eliminate their mild side effects to the host’s health. Full article
(This article belongs to the Special Issue Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers)
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