Neurological and Neurodevelopmental Disorders: Models, Drugs and Technologies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 6
Special Issue Editor
Interests: anticancer drug discovery; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurological and neurodevelopmental disorders represent a major global health challenge, affecting millions across all age groups and imposing substantial burdens on individuals, families, and healthcare systems. These conditions—ranging from autism spectrum disorder and ADHD to Alzheimer's disease and Parkinson's disease—share complex pathophysiological mechanisms that remain incompletely understood, limiting the development of effective therapeutic interventions.
Recent advances in disease modeling, including three-dimensional cell cultures, brain organoids, and organ-on-chip technologies, have opened unprecedented opportunities to study these disorders at the molecular and cellular levels. Concurrently, the integration of artificial intelligence and machine learning into drug discovery platforms, combined with high-throughput screening methodologies, is accelerating the identification of novel therapeutic candidates from both natural and synthetic sources.
This Special Issue will bring together cutting-edge research that advances our understanding of neurological and neurodevelopmental disorders through innovative models, therapeutic agents, and emerging technologies. We welcome original research articles, comprehensive reviews, and perspectives that explore the following:
- Advanced disease modeling systems (organoids, 3D cultures, organ-on-chip);
- Molecular mechanisms, signaling pathways, and disease heterogeneity;
- Therapeutic discovery: natural products, drug repurposing, and novel compounds;
- AI/machine learning applications and high-throughput screening platforms;
- Precision medicine and individualized therapeutic strategies;
- Translational research bridging basic science to clinical applications.
We invite contributions that span a spectrum from basic molecular investigations to translational applications, fostering interdisciplinary collaboration to advance the field of neurological research and therapeutic development.
Prof. Dr. Su-Yun Lyu
Guest Editor
Manuscript Submission Information
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Keywords
- neurodevelopmental disorders
- disease modeling
- molecular mechanisms
- neurological
- precision medicine
- individualized therapeutic strategies
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