The Role of Fibroblasts in the Regulation of Tissue Inflammation and Repair
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 226
Special Issue Editor
Interests: fibroblast; wound healing; tissue repair; phanolic compounds; antiseptics; laser therapy; phytotherapy
Special Issue Information
Dear Colleagues,
Fibroblasts are increasingly recognized as dynamic and functionally diverse cells rather than merely passive structural components of connective tissues. Their remarkable heterogeneity and plasticity enable them to integrate inflammatory signals, remodel the extracellular matrix (ECM), and ultimately determine the outcome of tissue repair processes, ranging from complete healing to pathological fibrosis.
This Special Issue seeks original research articles and comprehensive reviews that advance our understanding of the molecular and cellular mechanisms by which fibroblasts regulate tissue inflammation and repair. Relevant topics include but are not limited to immune–stromal crosstalk; myofibroblast differentiation and resolution; ECM remodeling and mechanotransduction pathways; fibroblast senescence and the senescence-associated secretory phenotype (SASP); paracrine communication mediated by exosomes and other extracellular vesicles; and bioengineering strategies designed to modulate fibroblast function (e.g., hydrogels, scaffolds, and smart biomaterials).
The main aim of this Special Issue is to bridge fundamental mechanistic insights with clinically actionable strategies to advance scar-modulating and pro-reparative interventions.
Prof. Dr. Rebeca Illescas Montes
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- fibroblast
- wound healing
- inflammation
- tissue repair
- immune–stromal crosstalk
- extracellular matrix remodeling
- myofibroblast
- regenerative medicine
- exosomes
- biomaterials
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
