The Role of Fibroblasts in the Regulation of Tissue Inflammation and Repair
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 14
Special Issue Editor
Interests: fibroblast; wound healing; tissue repair; phanolic compounds; antiseptics; laser therapy; phytotherapy
Special Issue Information
Dear Colleagues,
Fibroblasts are increasingly recognized as dynamic and functionally diverse cells rather than merely passive structural components of connective tissues. Their remarkable heterogeneity and plasticity enable them to integrate inflammatory signals, remodel the extracellular matrix (ECM), and ultimately determine the outcome of tissue repair processes, ranging from complete healing to pathological fibrosis.
This Special Issue seeks original research articles and comprehensive reviews that advance our understanding of the molecular and cellular mechanisms by which fibroblasts regulate tissue inflammation and repair. Relevant topics include but are not limited to immune–stromal crosstalk; myofibroblast differentiation and resolution; ECM remodeling and mechanotransduction pathways; fibroblast senescence and the senescence-associated secretory phenotype (SASP); paracrine communication mediated by exosomes and other extracellular vesicles; and bioengineering strategies designed to modulate fibroblast function (e.g., hydrogels, scaffolds, and smart biomaterials).
The main aim of this Special Issue is to bridge fundamental mechanistic insights with clinically actionable strategies to advance scar-modulating and pro-reparative interventions.
Prof. Dr. Rebeca Illescas Montes
Guest Editor
Manuscript Submission Information
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Keywords
- fibroblast
- wound healing
- inflammation
- tissue repair
- immune–stromal crosstalk
- extracellular matrix remodeling
- myofibroblast
- regenerative medicine
- exosomes
- biomaterials
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