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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Fundamental and Translational Insights into Colorectal Cancer

edited by Giuseppe Broggi

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4381 | Submission Open

Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Advances in Protein Structure-Function and Drug Discovery

edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth

submission deadline 20 Mar 2026 | 5 articles | Viewed by 4249 | Submission Open

Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery

(This special issue belongs to the Section Macromolecules)

Advanced Molecular Research on Retinopathy and Protection

edited by

Jaeyon Won

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4203 | Submission Open

Keywords: retinopathy; neuroprotection; antioxidants; innovative therapy; emerging technology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenesis of Preeclampsia: From a Molecular Perspective

edited by Jezid Miranda

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4155 | Submission Open

Keywords: preeclampsia; immune system; molecular mechanisms in preeclampsia; angiogenic factors; gene regulation; epigenetics; transcription factors in preeclampsia; translational research in preeclampsia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research on Biomimetic Chromatography, QSAR and Chemoinformatics in Molecular Modeling and Drug Design

edited by

Małgorzata Janicka

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4144 | Submission Open

Keywords: biomimetic chromatography; QSARs; QRARs; molecular modelling; chemoinformatics; pharmacokinetics

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanism and Therapeutic Approaches of Breast Cancer, Metastatic Breast Cancer, 3rd Edition

edited by

Mi Kyung Park

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4140 | Submission Open

Keywords: breast cancer; metastatic breast cancer; epithelial-to-mesenchymal transition (EMT); epigenetic and post-translational modifications (PTM); tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

The Food Processing Industry’s 200th Anniversary: Bioactive Compounds, Antioxidants, and Potential Health Benefits (2nd Edition)

edited by

Vassilis Athanasiadis

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4137 | Submission Open

Keywords: antioxidants; bioactive compounds; food processing; functional foods; green processes; health potentials; molecular mechanisms; polyphenols; shelf life; vitamins

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nanotechnology and Nanomedicine: Approaches, Challenges and Translation for Tissue Regeneration

edited by

Dinesh Kumar Srinivasan

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4137 | Submission Open

Keywords: nanotechnology; bone regeneration; skin regeneration; cardiac tissue regeneration; brain tissue regeneration; drug delivery system; targeted therapy

(This special issue belongs to the Section Molecular Nanoscience)

Antifungal Potential of Botanical Compounds

edited by Francisca Sempere-Ferre

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4134 | Submission Open

Keywords: botanical compounds; antifungal agents; natural products; secondary metabolites; fungal growth inhibition; bioactive plant extracts; eco-friendly antifungals; natural product chemistry; sustainable antifungal solutions; plant-derived bioactives

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities

edited by

Chuan Li

and

Jun Yang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4126 | Submission Open

Keywords: multiomics technologies; functional foods; characterization; structures; biological activities; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Role of Anthranilic Acid in Neuropsychiatric Diseases

edited by

Gregory F. Oxenkrug

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4028 | Submission Open

Keywords: anthranilic acid; Alzheimer’ s disease; autism; schizophrenia; bipolar disorder; major depressive disorder; post-partum depression; COVID-19; interferons; attention deficit disorder; cognitive impairment; G-protein-coupled receptor 109A; microbiome; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Drug Discovery and Development Focusing on Natural Products

edited by

Chung-Hsin Wu

and

Szu-Chuan Shen

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3989 | Submission Open

Keywords: natural products; drug R& D; herbal medicine; gut microbiota; mechanism of action; therapeutic targets

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Dynamics Simulation of Biomolecules

edited by

Pavel Rehak

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3972 | Submission Open

Keywords: molecular dynamics simulations; biochemical processes; biomaterial properties

(This special issue belongs to the Section Molecular Biophysics)

Advances in Molecular Therapeutics for HIV Co-Infections

edited by

Vishwanath Venketaraman

and

Selvakumar Subbian

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3908 | Submission Open

Keywords: HIV co-infections; molecular therapeutics; Mtb; ART; immune responses

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Natural Products in Inflammation

edited by

Antonia Cianciulli

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3862 | Submission Open

Keywords: inflammation; natural products; immunomodulation; bioactive compounds; drug discovery; drug target identification; anti-inflammatory activity; antioxidant activity; cellular signalling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Cancer Biomarkers and Metabolic Vulnerabilities

edited by Francesca Bersani

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3831 | Submission Open

Keywords: cancer metabolism; cancer biomarkers; liquid biopsy; therapeutic targets; metabolic rewiring

(This special issue belongs to the Section Biochemistry)

Macro- and Micronutrients in Health and Diseases

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3822 | Submission Open

Keywords: macronutrients; micronutrients; vitamins; macrominerals; trace elements; cancer; obesity; cardiovascular diseases; diabetes; osteoporosis; immune disorders; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Kidney Disease/Renal Dysfunction

edited by

Hiroshi Nonoguchi

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3821 | Submission Open

Keywords: kidney disease/renal dysfunction; hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) inhibitors; renal anemia; chronic renal faikure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Computational Biology: Molecular Dynamics Simulation of Biomolecules

edited by

Paulino Gómez-Puertas

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3793 | Submission Open

Keywords: computational biology; molecular dynamics; molecular simulation of rare diseases; computational design of antimicrobials; computational design of antivirals; molecular simulation of cancer-related processes; computational design of anti-cancer molecules; molecular simulation of biotechnology processes

(This special issue belongs to the Section Molecular Informatics)

Molecular Pathogenesis and Therapeutic Innovations in Oral Diseases

edited by Tatsuji Nishihara

submission deadline 20 Mar 2026 | 4 articles | Viewed by 3769 | Submission Open

Keywords: molecular-based analysis; diagnosis of oral disease; oral disease treatment; regeneration therapy; drug therapy; periodontitis; implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structure-Based Design of Drugs and Biologically Active Molecules Based on Computer-Aided Drug Discovery

edited by

Cleydson Breno Rodrigues dos Santos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3762 | Submission Open

Keywords: drug design; virtual screening; bioinformatics; chemoinformatics; quantum chemistry

(This special issue belongs to the Section Molecular Informatics)

Dialogue Between Inflammation and Immunity: From Mechanism to Therapy

edited by

Nikolina Mihaylova

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3751 | Submission Open

Keywords: inflammation; immune activation; immunomodulation; tolerance; immunotherapy; autoimmune diseases; cancer

(This special issue belongs to the Section Molecular Immunology)

Molecular Modelling in Material Science

edited by

Aggelos Avramopoulos

and

Filippos Sofos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3671 | Submission Open

Keywords: molecular materials; molecular structure; molecular modelling; material design

(This special issue belongs to the Section Materials Science)

New Research on the Biological Activities of Natural Components and Their Application

edited by

Željana Fredotović

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3661 | Submission Open

Keywords: natural compounds; traditional and medicinal plants; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way

edited by

Mariano Francesco Caratozzolo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3642 | Submission Open

Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism and Therapeutic Approach of Metal Toxicity

edited by Grażyna Gromadzka

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3609 | Submission Open

Keywords: metal toxicity; neurodegenerative disease; cancer; stroke; myocardial infarct; atherosclerosis; cardiovascular disease; metal chelators; therapeutic approach of metal toxicity; cobalt toxicity; copper toxicity; iron toxicity; aluminum toxicity; manganese toxicity; molybdenum toxicity; nickel toxicity; zinc toxicity; lead toxicity

(This special issue belongs to the Section Molecular Toxicology)

Molecular Advances in Inborn Errors of Immunity

edited by Aleksandra Szczawińska-Popłonyk

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3602 | Submission Open

Keywords: inborn errors of immunity; immune dysregulation; autoimmunity; autoinflammation; organ-specific immunopathology; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Investigation of Natural Products as Sources of Bioactive Molecules, 2nd Edition

edited by

Stefania Garzoli

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3579 | Submission Open

Keywords: metabolomic; secondary metabolites; phytochemical analysis; bioactivity; chemical investigation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Electrochemistry: Molecular Advances and Challenges

edited by

Miguel A. Esteso

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3548 | Submission Open

Keywords: fundamental electrochemistry; electroanalytical techniques; sensors and biosensors; nano-electrochemistry; electrochemical energy production and storage; environmental electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3502 | Submission Open

Keywords: genetic diseases; genotype– phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights into the Environmental Toxicity of Contaminants and Risk Mitigation Strategies

edited by

Barbara Mognetti

and

Tiziana Cappello

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3479 | Submission Open

Keywords: microplastic toxicity; environmental pollutants; molecular mechanisms; cell metabolic pathways; in vivo; in vitro; and in silico models; pollutant interactions; risk mitigation strategies

(This special issue belongs to the Section Molecular Toxicology)

Metabolomics in Oncology

edited by

Susan Costantini

and Elena Di Gennaro

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3472 | Submission Open

Keywords: metabolome; cancer; oncology; nuclear magnetic resonance; mass spectrometry

(This special issue belongs to the Section Molecular Oncology)

How Aging Results in Cognitive Decline: Molecular Mechanisms

edited by Holly Christian Hunsberger

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3445 | Submission Open

Keywords: aging; memory; hippocampus; neurodegeneration; sex; gender; exercise; synapses; metabolism; mitochondria

(This special issue belongs to the Section Molecular Neurobiology)

Medicinal Mechanisms of Biologically Active Compounds in Cancer

edited by

Karthik Gourishetti

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3353 | Submission Open

Keywords: biologically active compounds; cancer treatment; apoptosis; tumor growth; natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3301 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Epigenetic Mechanisms in Cognition

edited by Sabrina Venditti

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3253 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; noncoding RNAs; cognition; learning and memory; neuroplasticity; neurodegeneration; ASD; training

(This special issue belongs to the Section Molecular Biology)

Advances in Diabetic Ischemic Heart Failure

edited by Branko Beleslin

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3180 | Submission Open

Keywords: diabetes; ischemic cardiomyopathy; pathophysiology; diagnostics; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Female Reproductive Physiology

edited by Tomoko Fujiwara and

Masanori Ono

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3161 | Submission Open

Keywords: circadian rhythm; diet; hypothalamus; lifestyle habits; ovary; pituitary; preconception care; reproduction function; reproductive behavior; uterus

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advancing Occupational Health Through Omics Technologies

edited by

Silvia Vivarelli

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3139 | Submission Open

Keywords: omics technologies; occupational health; biomarkers; personalized risk assessment; workplace exposures; genomics; proteomics; psychosocial factors; disease susceptibility; preventive medicine

(This special issue belongs to the Section Molecular Biology)

Hormones: Evolutionary and Functional Role

edited by

Giulia Guerriero

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3128 | Submission Open

Keywords: hormone action; brain organization; sexual behavior; endocrine tissue; receptor neuroexpression; endocrine control; endocrine disruption; climate change and reproduction; hormones and evolution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Oxidative Stress and Autophagy in Cancer Cells

edited by

Abdelhabib Semlali

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3115 | Submission Open

Keywords: oxidative stress; autophagy; apoptosis; cancer cells; cancer cell signaling pathways

(This special issue belongs to the Section Molecular Biology)

Pathogenesis, Biomarkers and Therapeutic Perspectives of Ocular Diseases

edited by

Eugenia Piragine

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3096 | Submission Open

Keywords: ocular diseases; dry eye; glaucoma; diabetic retinopathy; macular degeneration; molecular mechanisms; diagnosis; preclinical research; clinical studies; drug therapy; pharmacology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Embryonic Development

edited by

Jacek Z. Kubiak

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3077 | Submission Open

Keywords: embryonic development; molecular mechanisms; cellular mechanisms; model embryos; genetic

(This special issue belongs to the Section Molecular Biology)

Recent Molecular Basis of Neurocognitive Mechanism

edited by

Poppy Schoenberg

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3015 | Submission Open

Keywords: cognitive functioning; epigenomics; high-throughput omics; metabolomics; molecular pathways; multi-modal datasets; neurocognition; neurodegeneration; neurorehabilitation; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Neurobiology)

New Research in Spatial Proteomics

edited by

Andrew Smith

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3008 | Submission Open

Keywords: spatial proteomics; mass spectrometry imaging; mass cytometry; biomarker; machine learning; spatial biology; molecular pathology; cancer

(This special issue belongs to the Section Molecular Informatics)

Recent Advances in New Biomarkers for Cancers

edited by

Maria Panagopoulou

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2955 | Submission Open

Keywords: biomarkers; cancer research; liquid biopsy; epigenetic and genetic biomarkers; precision oncology; diagnosis; prognosis; prediction

(This special issue belongs to the Section Molecular Oncology)

Novel Insights into Reproductive Toxicology

edited by Maria Cristina Budani

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2834 | Submission Open

Keywords: endocrine disruptors; environmental toxicants; fertility; heavy metals; lifestyle habits; molecular mechanisms; pregnancy; teratology; teratogenic compounds; reproductive toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Pharmacology and Interventions in Cardiovascular Disease: 2nd Edition

edited by

Magdalena Zabielska-Kaczorowska

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2785 | Submission Open

Keywords: cardiovascular pharmacology; cardiovascular interventions; cardioprotection; myocardial ischemia and infarction; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Metabolism in Human Health and Disease

edited by

Abdelnaby Khalyfa

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2710 | Submission Open

Keywords: molecular metabolism; metabolic pathways; insulin resistance; Warburg effect; chronic disease; metabolomics; precision medicine; metabolic dysfunction; cancer metabolism; personalized nutrition; enzyme-targeted therapy; systems biology; cellular energy; metabolic health; preventative healthcare

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Biomechanics of Cardiovascular Remodeling

edited by

Kevin Willy

and Maximilian Doldi Philipp

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2685 | Submission Open

Keywords: cardiovascular remodeling; cardiac imaging; cardiovascular intervention; cardiovascular pathways; cardiovascular research; structural heart disease; cellular signaling

(This special issue belongs to the Section Molecular Biophysics)

Displaying special issue 1151-1200 on page 24 of 64.

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