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Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities
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Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1875

Special Issue Editors

Prof. Dr. Chuan Li

E-Mail Website
Guest Editor
School of Food Science and Engineering, Hainan University, Haikou, China
Interests: seafood; food nutrition; food processing and storage; metabonomics; lipidomics; lipid metabolism; 3D-printed food; protein; new processing technologies
Special Issues, Collections and Topics in MDPI journals
Dr. Jun Yang

E-Mail Website
Guest Editor
College of Food Science and Engineering, Hainan University, Haikou, China
Interests: resveratrol; curcumin; oral deliery system; polysaccharides; intestinal inflammation; gut microbiota; metabonomics

Special Issue Information

Dear Colleagues,

Functional foods have gained increasing attention for their potential to promote health and prevent diseases. These foods contain bioactive components that exert health benefits beyond basic nutrition, such as anti-inflammatory, antioxidant, and anti-obesity properties, as well as immune and intestinal regulation. Nevertheless, the molecular mechanisms and targets of action underlying their efficacy remain incompletely understood, limiting their application in health foods. Understanding the mechanism of bioactivities and efficacy of those functional foods from different sources requires an in-depth knowledge of their basic structure, molecular characterization, and bioactivities, as evidenced by various in vitro and in vivo studies. With the rapid development of multiomics technologies such as genomics, proteomics, metabolomics, and transcriptomics, it has been widely used to identify, characterise and functionally analyse key biomolecules comprehensively and to elucidate the intrinsic connections between their structural properties and molecular mechanisms.

This Special Issue, titled “Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities”, invites original research and review articles focused on the molecular-level investigation of functional foods. Topics include, but are not limited to, omics-based identification of bioactive compounds, structural elucidation of these bioactives, and the underlying molecular mechanisms of their health benefits.

Authors are encouraged to integrate molecular biology, structural analysis, and biomolecular experiments to provide novel insight into the bioactive mechanisms of functional foods. Submissions should emphasize the mechanistic interplay between bioactive components and biological systems. Studies that employ genomics, proteomics, metabolomics, or similar multiomics technologies are particularly welcome in order to advance the field of functional food science.

Dr. Chuan Li
Dr. Jun Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiomics technologies
  • functional foods
  • characterization
  • structures
  • biological activities
  • molecular mechanisms

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Published Papers (2 papers)

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Research

29 pages, 13984 KiB  
Article
Inter- and Transgenerational Effects of In Ovo Stimulation with Bioactive Compounds on Cecal Tonsils and Cecal Mucosa Transcriptomes in a Chicken Model
by Mariam Ibrahim, Marek Bednarczyk, Katarzyna Stadnicka and Ewa Grochowska
Int. J. Mol. Sci. 2025, 26(3), 1174; https://doi.org/10.3390/ijms26031174 - 29 Jan 2025
Cited by 1 | Viewed by 830
Abstract
Exploring how early-life nutritional interventions may impact future generations, this study examines the inter- and transgenerational effects of in ovo injection of bioactive compounds on gene expression in the cecal tonsils and cecal mucosa using a chicken model. Synbiotic PoultryStar® (Biomin) and [...] Read more.
Exploring how early-life nutritional interventions may impact future generations, this study examines the inter- and transgenerational effects of in ovo injection of bioactive compounds on gene expression in the cecal tonsils and cecal mucosa using a chicken model. Synbiotic PoultryStar® (Biomin) and choline were injected in ovo on the 12th day of egg incubation. Three experimental groups were established in the generation F1: (1) a control group (C) receiving 0.9% physiological saline (NaCl), (2) a synbiotic group (SYN) receiving 2 mg/embryo, and (3) a combined synbiotic and choline group (SYNCH) receiving 2 mg synbiotic and 0.25 mg choline per embryo. For the generations F2 and F3, the SYN and SYNCH groups were each divided into two subgroups: (A) those injected solely in F1 (SYNs and SYNCHs) and (B) those injected in each generation (SYNr and SYNCHr). At 21 weeks posthatching, cecal tonsil and cecal mucosa samples were collected from F1, F2, and F3 birds for transcriptomic analysis. Gene expression profiling revealed distinct intergenerational and transgenerational patterns in both tissues. In cecal tonsils, a significant transgenerational impact on gene expression was noted in the generation F3, following a drop in F2. In contrast, cecal mucosa showed more gene expression changes in F2, indicating intergenerational effects. While some effects carried into F3, they were less pronounced, except in the SYNs group, which experienced an increase compared to F2. The study highlights that transgenerational effects of epigenetic modifications are dynamic and unpredictable, with effects potentially re-emerging in later generations under certain conditions or fading or intensifying over time. This study provides valuable insights into how epigenetic nutritional stimulation during embryonic development may regulate processes in the cecal tonsils and cecal mucosa across multiple generations. Our findings provide evidence supporting the phenomenon of epigenetic dynamics in a chicken model. Full article
(This article belongs to the Special Issue Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities)
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14 pages, 2892 KiB  
Article
Mechanism of Functional Compound Fruit Drinks in Regulating Serum Metabolism in Constipated Mice
by Quanhong Lu, Yali Shi, Xin Wen, Lulu Zhu, Longteng Zhang, Kexue Zhu, Jun Cao and Chuan Li
Int. J. Mol. Sci. 2025, 26(2), 702; https://doi.org/10.3390/ijms26020702 - 15 Jan 2025
Viewed by 738
Abstract
A compound fruit drink (CFD) is a functional beverage containing fruits, Chinese herbal medicine, and prebiotic fructose. Previous studies have shown the effect of a CFD on alleviating constipation and its impact on gut microbiota. However, a comprehensive analysis has not been reported [...] Read more.
A compound fruit drink (CFD) is a functional beverage containing fruits, Chinese herbal medicine, and prebiotic fructose. Previous studies have shown the effect of a CFD on alleviating constipation and its impact on gut microbiota. However, a comprehensive analysis has not been reported in regard to the serum metabolism of CFDs. This study established a mouse constipation model, using loperamide hydrochloride. Herein, based on UHPLC–QTOF/MS analysis, 93 differential metabolites (mainly including phosphoglycerides and amino acid derivatives) among the groups of mice were identified. After CFD treatment, the content of phosphatidylethanolamine, amino acid derivatives (including N-Acetyl-L-aspartate, L-Norleucine, and cis-4-Hydroxy-D-proline), and fumarate increased, while that of esters decreased. Pathway enrichment analysis revealed that the CFD mitigated constipation by modulating nine metabolic pathways, which encompass glycerophospholipid metabolism, the tricarboxylic acid (TCA) cycle, pyruvate metabolism, and tyrosine metabolism. Notably, the glycerophospholipid metabolic pathway was identified as the most pertinent. Collectively, the results provide new ideas for developing functional foods that nourish the intestines and relieve constipation. Full article
(This article belongs to the Special Issue Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities)
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